[PDF] Top 20 The oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae.
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The oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae.
... of Tax/ATF-1/ CREB in yeast cells through expression of b -galactosidase driven by a yeast minimal promoter containing ATF-1/CREB binding sites within two HTLV-1 ... See full document
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Tax 1-Independent Induction of Vascular Endothelial Growth Factor in Adult T-Cell Leukemia Caused by Human T-Cell Leukemia Virus Type 1
... Human T-cell leukemia virus type 1 (HTLV-1) is the etio- logical agent of adult T-cell leukemia (ATL) and a neurode- generative disease termed ... See full document
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XBP-1, a Novel Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Binding Protein, Activates HTLV-1 Basal and Tax-Activated Transcription
... the CREB/ATF family of transcription factors. XBP-1 plays a major role in the cellular unfolded protein response (UPR), which is triggered by accumulation of unfolded or ... See full document
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Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein
... Human T-cell leukemia virus type 1 (HTLV-1) is the etio- logical agent of adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated ... See full document
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SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription
... Human T-cell leukemia virus type 1 (HTLV-1)-associated diseases are poorly treatable, and HTLV-1 vaccines are not ...encodes Tax oncoprotein, ... See full document
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Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter.
... for Tax regulation of the PCNA promoter can be envisioned. Tax could physically bind to the protein(s) in this complex, bringing it into the proximity of the PCNA promoter where it could influence ... See full document
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Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction
... The Tax-CBP interaction is likely to be important for viral replication in the context of initial infection of quiescent cells in which CREB might not be phosphorylated and therefore be unable to ... See full document
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Human T-Cell Leukemia Virus Type 2 Tax Mutants That Selectively Abrogate NFκB or CREB/ATF Activation Fail To Transform Primary Human T Cells
... The human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are oncogenic retroviruses associated with hu- man T-cell malignancies and degenerative ... See full document
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The Four and a Half LIM Family Members Are Novel Interactants of the Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein
... its interaction with ...its interaction with ...its interaction with certain binding partners (17, ...acids 1 to 50 at the N terminus and amino acids 181 to 353 at the C terminus, which ... See full document
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The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription
... The human T-cell leukemia virus type 1 (HTLV-1) viral protein Tax is a transactivator of transcription driven by the cognate viral long terminal ... See full document
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Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.
... of T lymphocytes by HTLV-1 is due primarily to the expression of the 40-kDa Tax retrovirus oncoprotein, which deregulates a variety of impor- tant cellular processes (6, ...13). ... See full document
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CREB-2, a Cellular CRE-Dependent Transcription Repressor, Functions in Association with Tax as an Activator of the Human T-Cell Leukemia Virus Type 1 Promoter
... labeled Tax bound to GST-CREB-2. This result demonstrated that Tax interacted directly with ...the interaction between Tax and CREB-2, the same in vitro binding assay was carried ... See full document
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CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein
... the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation contributing to the development of ... See full document
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Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
... complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several proteins that are unique to the virus within its 3 ⴕ -end ...transactivator ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Dysregulates β-Catenin Signaling
... transformed T-cell lines and that Tax activates Akt in these cells ...HTLV-1-infected T-cell lines, we examined the phosphorylation status of Akt and the in vitro Akt ... See full document
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The Cellular Autophagy Pathway Modulates Human T-Cell Leukemia Virus Type 1 Replication
... in cellular proliferation, differentiation, and development, and it is essential for the survival of HTLV-1-infected cells (25, 72, ...73). Tax has been found to activate NF- B through canonical ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Protein Down-Regulates Pre-T-Cell Receptor Alpha Gene Transcription in Human Immature Thymocytes
... the transcription from the specific reporter construct ...the transcription from EP180 ...detect Tax con- firmed the presence of a 40-kDa protein in cells transfected with pCMV-Tax and ... See full document
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Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity
... of Tax or altered Tax conformation ...of Tax with in- creased transfection of Myc-ubiquitin (Fig. 4A, ␣Tax, lanes 5 to ...in Tax activity, we next treated 293 cells transfected with ... See full document
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Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53
... for Tax-p53 interaction, we first assessed the reported re- pressive activity of Tax on ...p53-negative cell lines, HeLa, Saos-2, and ...(Fig. 1). When wild-type Tax ... See full document
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Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes.
... Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with a variety of ... See full document
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