[PDF] Top 20 Organometallic iridium anticancer complexes
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Organometallic iridium anticancer complexes
... metal complexes which possess anticancer ...metal-based anticancer drugs may be able to widen the spectrum of treatable cancers, reduce toxic side-effects, and overcome platinum ...of ... See full document
259
Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity
... iodido complexes 9 (2-F), 13 (2-Cl), 17 (2-Br), and 23 (3-Cl), and two chlorido complexes 19 (2-Br), and 25 (3-Cl), all biphenyl arene complexes, using the “shake tube ...these complexes ... See full document
37
Pharmaco genomic investigations of organo iridium anticancer complexes reveal novel mechanism of action
... We carried out pathway analysis with Ingenuity Pathway Analysis software which uses an extensive literature database (Ingenuity Knowledge Base) to integrate biological and chemical pathway perturbation information. 23 ... See full document
16
β‐Ketoiminato iridium(III) organometallic complexes: Selective cytotoxicity towards colorectal cancer cells HCT116 p53‐/‐
... However, when the Cp † ligand was extended to contain more phenyl rings, the complexes exhibited intercalation with DNA bases and had good potency towards cancerous cells. Additionally, when changing the chelating ... See full document
8
Photoactivatable organometallic pyridyl ruthenium(II) arene complexes
... other complexes so that their generation is ...potential anticancer agents with discriminating preference towards ...pyridine-derivative complexes, studies on CT-DNA interactions in cell-free media ... See full document
48
Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents.
... containing (N,N)-binding picolinamide ligands and their cytotoxicities on either HT-29, MCF-7 or A2780 cells have been tested. The Ir-Cp* chloride unfunctionalised picolinamide complex, 1, shows modest activity which, ... See full document
25
Rhodium and Iridium in Organometallic Catalysis171-176
... nitrogen was n-butyl (8), the outcome of the reac- tion depended on the linker length, n. For short linkers (n = 1 or 2) the product was the 2:1 com- plex, but for longer linkers (n = 3 or 4) the product was the ... See full document
6
Cyclic peptide–polymer nanotubes as efficient and highly potent drug delivery systems for organometallic anticancer complexes
... The well-studied monomer building block 2-hydroxypropyl methacrylamide (HPMA) was chosen as the main monomer for designing the polymeric drug used in this work. In order to provide a binding site for the ligation of ... See full document
27
Mirror image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity
... iodido complexes have surpris- ingly similar selectivity patterns to one another and to an anti-microtubule drug, vinblastine ...than anticancer activity, 2 and 4 also demonstrated potential as ... See full document
12
Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity
... The ability of the peptide conjugates 46 to deliver osmium to DNA follows the order 6 >> 5 > 4 (Figure 7). Octaarginine complex 6 delivers over 4- fold more Os to DNA compared to complex 5 and 15- fold more ... See full document
36
Contrasting anticancer activity of half sandwich iridium(III) complexes bearing functionally diverse 2 phenylpyridine ligands
... All complexes hydrolyze rapidly at 310 K, but total suppression of aquation can be achieved with 4 mM NaCl, implying that under physiological conditions the complexes would exist as the neutral chlorido ... See full document
13
Iridium Complexes with Cp* Ligand: Synthesis, Characterization and Application in Catalysis.
... reactions in industry often undergo radical autoxidation processes. For example, in the oxidation of terephthalic acid, a starting compound for the manufacture of polyester, used in clothing and to make plastic bottles. ... See full document
116
Iridium (Iii) –Hydridocyclometallated-Imine Complexes, As A Result Of C-H Bond Activation In Coordinated Ligand, Spectroscopic Studies
... cyclometallated complexes represent one of the most interesting and broadly studied class of organo-transition metal ...generating organometallic systems, with very important potential (Crabtree, ... See full document
6
One-step templated synthesis of chiral organometallic salicyloxazoline complexes
... conclusion, complexes 1–8 were obtained using a one-pot method with a sequential strategy ...afford organometallic com- plexes in good yields ...these complexes as chiral ligands are currently ... See full document
9
Metal complexes as DNA intercalators
... (37) Wang, F. Y.; Xu, J. J.; Habtemariam, A.; Bella, J.; Sadler, P. J. Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex : detection of a sulfenato intermediate. J. Am. Chem. ... See full document
46
Iridium complexes of the conformationally rigid IBioxMe4Ligand : hydride complexes and dehydrogenation of cyclooctene
... for organometallic chemistry and catalysis (Chart 1) – the readily adapted bioxazoline backbone provides a versatile scaffold for the synthesis of achiral and chiral ligands with tuneable steric ... See full document
20
Potent half sandwich iridium(III) anticancer complexes containing C∧N Chelated and pyridine ligands
... all complexes display weak nucleobase binding to 9-ethylguanine, suggesting that DNA could be a possible target, although other targets appear to be more ...of complexes 1 and 5. However, the iridium ... See full document
11
Ultrafast photophysics of iridium complexes
... that organometallic complexes display has led to numerous natural and synthetic uses for this class of ...metal complexes – generally through complex metalloprotein structures – to carry out material ... See full document
242
Mitochondria targeted spin labelled luminescent iridium anticancer complexes
... The anticancer activity of the bis-nitroxide complex Ir- TEMPO2 is 2 (A549 lung cancer cells) to 15 (PC3 prostate cancer cells) higher compared to the one TEMPO containing complex Ir-TEMPO1 (Table 2) showing an ... See full document
9
Catalytic organometallic anticancer complexes
... novel anticancer compounds may identify other chemotherapeutic targets, such as the previously discussed hypoxic environment, 120, 121 high rate of glycolysis, 124 and increased levels of oxidative stress 129 in ... See full document
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