[PDF] Top 20 Original Article The efficacy and safety of lcotinib in patients with advanced non-small cell lung cancer: compare with gefitinib

... all, non-small-cell lung cancer (NSCLC) is one of the most lethal malignancies with few effective treatment ...the patients with EGFR ...to compare the efficacy and ... See full document

... the efficacy and safety of gefitinib and docetaxel in the treatment of non- small cell lung ...of gefitinib (treatment group) and docetaxel (control group) in the ... See full document

... long-term efficacy of continuous administration of Endostar (YH- 16) combined with vinorelbine (NVB) and cisplatin (DDP) in the treatment of advanced non-small cell lung ... See full document

... the efficacy and safety of gefitinib monotherapy in patients with locally advanced or metastatic NSCLC who failed previous chemotherapy regimens (Fukuoka 2003 IDEAL I; Kris 2003 IDEAL ... See full document

... the efficacy of gefitinib as first-line treatment of advanced ...with gefitinib treatment in 40 patients with advanced ...196 patients with NSCLC achieved an ORR of 42%, a ... See full document

... Icotinib hydrochloride was given orally at a dose of 125 mg three times daily until disease progression or intolerable toxicity. No other systematic anticancer treatment was adminis- tered concurrently with icotinib ... See full document

... Abstract: Gefitinib is the first epidermal growth factor receptor tyrosine-kinase inhibitor approved for the treatment of advanced non-small cell lung cancer ...comparable ... See full document

... the safety of beva- cizumab combined with first-line standard che- motherapy regimen in Chinese ...Chinese patients, the incidence of adverse events with grade 3 or higher was lower (<9%) ...the ... See full document

... Abstract: We investigated the association between the clinical outcome and GSTP1 and XRCC1 gene polymor- phisms in advanced NSCLC patients with cisplatin-based chemotherapy. We prospectively recruited 325 ... See full document

... spectrum, patients with more advanced stage NSCLC often require more extended surgery, and/or multimodality treatment, involving chemotherapy and radia- tion ...older patients represent a particular ... See full document

... of non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations carry uncommon ...the efficacy of first-generation EGFR-tyrosine kinase ... See full document

... of patients, sample size, and by ...the patients with advanced NSCLC ...39 patients with NSCLC, and they found that GSTP1 expression was associated inversely with response to chemotherapy and ... See full document

... the efficacy of the combined therapy for second-line or third-line NSCLC patients was ...for patients with NSCLC that have failed second-line treatment are needed ... See full document

... of patients who could benefit from the ...in patients with high PDL1 expression was slightly lower than that for the whole population, PDL1 expression levels may be inadequate to predict OS benefit, in ... See full document

... in patients with non-small cell lung cancer (NSCLC) harboring sensitizing mutations in the tyrosine kinase (TKI) domain has led to a significant change in the management of this ... See full document

... NSCLC patients treated solely with platinum-based ...the efficacy and safety profile of crizotinib vs chemotherapy (pemetrexed-cisplatin or pemetrexed-carboplatin) in previously untreated ... See full document

... in patients with advanced NSCLC compared with the ...in patients with advanced NSCLC. More than 90% of patients with cancer are treated outside randomized clinical trials, and ... See full document

... treatment efficacy of two therapies was compared between nitroglycerin combined with platinum-based regimens chemotherapy and single ...120 patients with NSCLC of progressive stage ...the efficacy ... See full document

... pancreatic cancer that is involved in tumor proliferation, metastasis, and induction of ...a small, yet statistically significant, survival benefit in advanced ...pancreatic cancer, albeit ... See full document

... Twenty-seven patients with advanced NSCLC were ...five patients experienced dose-limiting toxicities ...six patients had DLTs at the 50 mg/d ... See full document