[PDF] Top 20 Original Article Identification of key pathways and candidate genes in gliomas by bioinformatics analysis
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Original Article Identification of key pathways and candidate genes in gliomas by bioinformatics analysis
... cells and natural killer cells during the cellu- lar immune response, and mediated cancer cell death [20, 21]. By establishing a novel GZMB-targeted peptide and applying in non- invasive PET imaging assessment, Larimer ... See full document
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Original Article Identification of key genes in preeclampsia-associated trophoblast cells using bioinformatics analysis
... To validate the gene expression level of tropho- blastic cell signature resulting from microarray analyses, we selected five preterm and seven EOPE placenta tissues from GSE74341. As shown in Figure 4, the expression ... See full document
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Original Article Identification of the clinical diagnostic value of miR-10b-5p and the key targets and pathways in glioma, a study based on meta-analysis and bioinformatics
... expression analysis, we identi- fied hub genes PRKCE and EPHA4 were signifi- cantly down-regulated in GBM ...hub genes EPHA4 and NE- DD4L owned a great chance to act as crucial target genes of ... See full document
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Original Article Identification of molecular target genes and key pathways in nasopharyngeal carcinoma by integrated bioinformatic analysis
... target genes and key pathways involving the occurrence, development, and prognosis of nasopharyngeal carcinoma (NPC), and highlight their critical roles in management of ...expressed genes ... See full document
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Original Article Identification of key genes associated with idiopathic pulmonary fibrosis using bioinformatics analysis
... expressed genes (DEGs) between upper and lower lobe samples using paired t-tests, and identified DEGs between IPF explants and IPF biopsies using unpaired Student’s t-tests ...annotation analysis was ... See full document
9
Identification of key candidate genes and small molecule drugs in cervical cancer by bioinformatics strategy
... Driver genes play vital roles during stages of cancer pro- ...driver genes and candidate drugs that may shed light on CC ...enrichment analysis indicated that cell cycle, DNA replication, ... See full document
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Original Article Identification of key genes and pathways in human glioblastoma multiforme by co-expression analysis
... human gliomas, whereas downregulat- ed CDK1 inhibits proliferation activities of human malignant gliomas ...1, genes in the 3 clusters were mainly associated with cell cycle regulation, cell ... See full document
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Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis
... MF analysis, we found that majority of DMGs contributed to protein binding (16 genes), zinc ion binding (seven genes), metal ion binding (eight genes), DNA binding (six genes) and ... See full document
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Original Article Identifying key genes in rheumatoid arthritis using bioinformatics analysis
... Interacting Genes) to construct a PPI network to evaluate the rela- tionships among ...cluster analysis was utilized to construct subnetworks of the obtained PPI ...the genes related to the ... See full document
10
Original Article Prospective target genes and pathways of miR-30a-5p in colorectal cancer: an investigation using TCGA and bioinformatics analysis
... key tumor suppressor encoding tumor protein, has been reported to be implicated in the pathogenesis and development of multiple can- cers, including colon cancer [24]. As an experi- mentally verified target of ... See full document
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Original Article The identification of the key genes and pathways in septic shock using an integrated bioinformatics analysis
... The functional enrichment of the 403 upregulated and 251 downregulated candi- date DEGs were analyzed using the DAVID 6.8 data- base. Biological processes, cellular components, mo- lecular functions and KE- GG ... See full document
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Original Article Identification of candidate genes and pathways in cisplatin-resistant NSCLC by integrated bioinformatics analysis
... pathway analysis demonstrated that arrhythmogenic right ventricular cardiomyopathy, cell adhesion molecules, and ECM-receptor interaction were the enriched pathways of up-regulated DEGs, while ... See full document
8
Identification of key genes and pathways using bioinformatics analysis in septic shock children
... of Genes and Genomes (KEGG) in DAVID, which is an online tool, and Gene Set Enrichment Analysis (GSEA) software ...the candidate biomarkers for diagnosis, clinical care, and prognosis in septic shock ... See full document
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Original Article Candidate pathways and genes for nasopharyngeal carcinoma based on bioinformatics study
... Ebel B, Erwin P, Espindola P, Ezzati M, Feigin V, Flaxman A, Forouzanfar M, Fowkes F, Franklin R, Fransen M, Freeman M, Gabriel S, Gakidou E, Gaspari F, Gillum R, Gonzalez-Medina D, Halasa Y, Haring D, Harrison J, ... See full document
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<p>Identification of key pathways and hub genes in basal-like breast cancer using bioinformatics analysis</p>
... hub genes, and core pathways between BC (comparing the basal subtype and the non basal subtype) and matched normal controls were identified by the bioinformatics ...plotter analysis, gene ... See full document
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Original Article The identification of genes associated with NSCLC prognosis based on an integrated bioinformatics analysis
... expressed genes in NSCLC using a bioinformatics ...Up-regulated genes between cancer tissue and normal lung tis- sue from NSCLC patients were screened in the Oncomine ...up-regulated genes in ... See full document
8
Identification of key pathways and genes in <em>TP53 </em>mutation acute myeloid leukemia: evidence from bioinformatics analysis
... 1,287 genes were identified as DEGs. GO and KEGG analysis suggested that upregulation of DEGs was significantly enriched in categories associated with cell adhesion biological processes, Ras-associated ... See full document
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Identification of key genes and specific pathways potentially involved in androgen-independent, mitoxantrone-resistant prostate cancer
... Total tumor RNA was extracted using Trizol reagent (Takara, Dalian, China), and concentrations determined by a spectro- photometer (NanoDrop; Nyxor Biotech, Paris, France). All the processes were carried out according to ... See full document
12
<p>Bioinformatics analysis of molecular genetic targets and key pathways for hepatocellular carcinoma</p>
... The miRNAs are a series of small, non-coding regula- tory RNAs, which regulate gene expression and perform a crucial role in the regulation of proliferation, cellular differentiation and cell death. A part of miRNAs was ... See full document
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<p>Identification of key genes, pathways and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis</p>
... the bioinformatics analysis of Kyoto Encyclo- pedia of Genes and Genomes (KEGG) database, these differ- entially expressed genes (DEGs) were significantly enriched in the following signaling ... See full document
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