[PDF] Top 20 <p>Metabolic Dysfunction and Asthma: Current Perspectives</p>

... Insulin resistance can be broadly de fi ned as an impaired biologic response to insulin. This broad de fi ni- tion remains elusive as there is no generally accepted test for insulin resistance. In clinical practice, ... See full document

... analyzed asthma exacerbations as the main outcome (46% of the studies), but they also examined other measurements of treatment response such as lung function measurements (27%), FENO (9%), ACT score (9%), or ... See full document

... CRP, and fi brinogen may be seen in the course of CES. 11,36 Incidence of eosinophilia has been reported to be 14% – 71%. It is usually transient and induced by secreted IL5 due to acti- vated T cells. 2 CES with kidney ... See full document

... Abstract: Infantile Tremor Syndrome (ITS) is a self-limiting clinical state characterized by tremors, anemia, pigmentary skin disease, regression of mental development, and hypotonia of muscles in a plump looking child. ... See full document

... While some patients with LS are asymptomatic, most report a history of pruritus, dyspareunia, or vulvar pain. 3,15 Multiple studies have shown a high rate of sex- ual dysfunction in women with LS. 29 – 32 Women ... See full document

... Abstract: Calciphylaxis (CP) is a rare disorder presenting with painful ischemic skin ulcerations. Its association with end-stage renal disease, but also non-uremic cases have been described. Several risk factors, like ... See full document

... its metabolic origin in the diminished transforma- tion of fatty acid substrates into n-3 polyunsaturated fatty acids due to a dysregulation of the lipid ... See full document

... deranged metabolic functionality of bacterial communities in the gut were seen to change, with notable downregulation of methane metabolism, bacterial invasion of the epithelial cells, in fl ammatory arachidonic ... See full document

... complement pathway and coagulation cascades, and myo- cardial dysfunction. 16,17 IFN- γ can cause fl u-like symp- toms and can also trigger macrophage activation, leading to secretion of host cytokines such as ... See full document

... Kidney transplantation remains the gold standard for pediatric patients with ESRD regardless of etiology, as it provides a known survival advantage over peritoneal or hemodialysis. 62 A recent study by Yalcinkaya et al ... See full document

... Abstract: Dry eye disease (DED) is among the most common condition encountered during ophthalmic practice, reducing patient ’ s quality of life and work productivity. Most of DED cases have an evaporative component ... See full document

... dopamine, acetylcholine, gamma-aminobutyric acid, norepi- nephrine, nitric oxide, oxytocin, and other ones. 24 On the one hand, erectile function and sexual arousal have been related to the acetylcholine in the ... See full document

... LS is an autosomal dominant inherited syndrome where tumors develop from germline mutations in mismatch repair genes (MLH1, MSH2, MSH6 and PMS2). Mismatch repair dysfunction results in loss of protein expression ... See full document

... Abstract: The last 15 years have been the most fruitful in the history of research on the metabolic disorder alkaptonuria (AKU). AKU is caused by a de fi ciency of homogentisate dioxygenase (HGD), the enzyme ... See full document

... To date, the PHARMCLO trial is the largest trial that evaluated the bedside genotyping in selecting the appro- priate antiplatelet therapy (clopidogrel, ticagrelor, or pra- sugrel) and the associated outcomes in patients ... See full document

... Abstract: Medullary Sponge Kidney (MSK) disease is a rare congenital malformation of the distal nephron where cystic dilatation is appreciable in the collecting ducts and renal papillae. Most cases of the malformation ... See full document

... Abbreviations: PLT, platelet; PTP, post transfusion purpura; ITP, immune thrombocytopenic purpura; DITP, drug-induced thrombocytopenia; MAHA, microangiopathic hemolytic anemia; H/PF-4, h[r] ... See full document

... in asthma treatment and management; however, there is still a population of patients who remain difficult to ...achieving asthma control in patients with ...all asthma phe- notypes, irrespective of ... See full document

... direct current stimulation (tDCS) has arisen as a promising tool and has been proven to be safe and well tolerated for the treatment of many diseases, including chronic pain, depres- sion, and ... See full document

... A phase II trial of erlotinib as maintenance treatment after gemcitabine plus platinum-based chemo- therapy in patients with recurrent and/or metastatic nasopharyngeal carcinoma. Vermo[r] ... See full document