[PDF] Top 20 Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins
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Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins
... d109 genome, showing the coding sequences of the IE genes (solid arrows) and the deletion mutations (white bars) in ICP4 (d120), ICP0 (0D), and the ICP22/47 promoter ...different virus mutant strains are ... See full document
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Cellular SNF2H Chromatin Remodeling Factor Promotes Herpes Simplex Virus 1 Immediate Early Gene Expression and Replication
... its expression. The level of SNF2H associated with the viral genome decreased by 4 h postinfection and was nearly reduced to background levels by 8 h postinfection ...viral genome and this ... See full document
10
Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression
... and virus replication rapidly resumes (51, 63, 64, ...viral genome is se- questered in a nonlinear configuration, as in vivo, and no gene expression is detected; indeed promoters in the viral ... See full document
9
Temporal Association of the Herpes Simplex Virus Genome with Histone Proteins during a Lytic Infection
... Herpes simplex virus (HSV), a double-stranded DNA virus, infects epithelial cells and eventually establishes a latent infec- tion in ...gene expression during lytic infection is ... See full document
8
Herpes Simplex Virus 1 Immediate-Early and Early Gene Expression during Reactivation from Latency under Conditions That Prevent Infectious Virus Production
... gene expression was observed and interpreted as evidence that DNA replication potentiated gene expression during ...gene expression detected by ISH in untreated tissues at 48 h ...that ... See full document
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Differential Role of Sp100 Isoforms in Interferon-Mediated Repression of Herpes Simplex Virus Type 1 Immediate-Early Protein Expression
... Sp100 proteins at 2 to 4 h postinfection (7, 18, 40) at a time when IE transcripts can be detected at sites adjacent to ND10 or ND10- associated protein aggregates ...gene expression (20, 38), in part by ... See full document
11
Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells.
... stimulates expression of all three temporal classes of HSV genes during lytic infection (12, 71, 85, ...the absence of ICP0 function (84, ...viral genome are silenced along with the HSV lytic ... See full document
10
Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters.
... This activation was specific to hybrid genes containing DE regulatory regions since no significant increases in expression were observed in cotransfection experiments with the CAT gene w[r] ... See full document
10
Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene.
... It shows some functional similarity to enhancer sequences, since it stimulates expression of chimeric IE-TK genes even in the absence of the virion component Transcription of the herpes [r] ... See full document
9
The PK Domain of the Large Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Reductase (ICP10) Is Required for Immediate-Early Gene Expression and Virus Growth
... be induced or activated by virion structural proteins. Such an interpretation is consistent with the finding that replication begins 3 to 5 h earlier, when the cells are infected at a high (200 PFU/cell), rather ... See full document
11
Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis.
... the proteins required for the activa- tion of IE transcription (Oct-1, HCF, or VP16 ...the virus recombinant as for the transfor- mation of Vero ...the expression of both RNAs over that observed with ... See full document
7
Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27
... gene expression (38, 49, 50, ...seven proteins comprise the EJC, some of which (such as REF) are thought to promote nuclear export of the spliced RNA by recruiting the TAP/ NXF1 nuclear export ...gene ... See full document
12
A Pre-Immediate-Early Role for Tegument ICP0 in the Proteasome-Dependent Entry of Herpes Simplex Virus
... Herpes simplex virus (HSV) engages the host cell machinery in a coordinated manner during the initial stages of ...functional proteins, as well as the hydrolysis of aberrantly folded ... See full document
9
Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation
... varicella-zoster virus (human herpesvirus 3), another alphaher- pesvirus from the Varicellovirus genus, lacks a “canonical” SIAH-1 interaction motif, as do the betaherpesviruses human cytomegalovirus and human ... See full document
14
Role of Herpes Simplex Virus 1 Immediate Early Protein ICP22 in Viral Nuclear Egress
... erpes simplex virus 1 (HSV-1) is one of the best-studied members of the Herpesviridae family, causing a variety of dis- eases such as mucocutaneous diseases, keratitis, skin diseases, and life-threatening ... See full document
10
Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation.
... In further comparative analyses of the stimulatory functions of the IE175K and IEllOK proteins, we have shown that, although the responses were not as great as those observed for the IE1[r] ... See full document
11
Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... with virus lacking the VP22 gene, ICP0 failed to localize to these puncta to any degree ...the proteins were then assembled into the virus ...the virus at Wt levels without exhibiting ... See full document
15
The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27.
... mutants in ICP4 and ICP27, mutants in which ICP0 is inacti- vated can be propagated in cells that do not supply ICP0. However, the plating efficiency of ICP0 mutants on non- complementing cells is markedly reduced (74, ... See full document
12
Reactivation of Expression from Quiescent Herpes Simplex Virus Type 1 Genomes in the Absence of Immediate-Early Protein ICP0
... which herpes simplex virus (HSV) is retained in human fibroblasts in a nonreplicating state known as ...(HSV-1) immediate-early (IE) protein ICP0, an important activator of gene ... See full document
9
Transcriptional Coactivators Are Not Required for Herpes Simplex Virus Type 1 Immediate-Early Gene Expression In Vitro
... mRNA expression was induced in both SW13 and C33-A cells upon the expression of BRM and Brg-1 but not the dominant neg- ative BRM and Brg-1 ...Brg-1 proteins ectopically expressed in these cell lines ... See full document
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