[PDF] Top 20 Phenotype of the herpes simplex virus type 1 protease substrate ICP35 mutant virus.
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Phenotype of the herpes simplex virus type 1 protease substrate ICP35 mutant virus.
... Phenotypic analysis of AICP35 shows that i mutant virus growth in Vero cells was severely restricted, although small amounts of progeny virus were produced; ii full-length ICP35 protein [r] ... See full document
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Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100
... ICP0-null mutant HSV-1 infection than cells depleted of either protein alone, the extent of the increase varied between inde- pendent sets of isolated ...epithelial phenotype and were derived from ... See full document
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The null mutant of the U(L)31 gene of herpes simplex virus 1: construction and phenotype in infected cells.
... deletion mutant exhibited typical cytopathic effects at high multiplicities of infection, and at low multiplicities of infection, small clusters of cells exhibiting cytopathic effects were readily ...infectious ... See full document
9
Separate functional domains of the herpes simplex virus type 1 protease: evidence for cleavage inside capsids.
... HSV-1 protease is not linked to the assembly of capsids, since the protease can undergo autopro- cessing and trans cleave ICP35 in transfected cells (26–28), an ...assembly-negative ... See full document
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Alterations in catalytic activity and virus maturation produced by mutation of the conserved histidine residues of herpes simplex virus type 1 protease.
... nonviable mutant, H61A-V730, showed an accumulation of highly symmetrical arrays of B capsids in the nuclei of infected Vero ...wild-type virus capsids and that the abnormal build-up of these ... See full document
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The C-terminal 25 amino acids of the protease and its substrate ICP35 of herpes simplex virus type 1 are involved in the formation of sealed capsids.
... HSV-1 protease with a Met-to-Leu change at residue 307, which corresponds to the initiation codon of ICP35 (9, 19, ...HSV-1 protease and ICP35 genes specified by pRB4057 carrying ... See full document
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Evidence for Controlled Incorporation of Herpes Simplex Virus Type 1 UL26 Protease into Capsids
... wild-type virus infection but that assembly of ⌬ICP35 cap- sids operates by a less efficient, alternative pathway under conditions of limited scaffold ... See full document
11
Exonuclease-Deficient Polymerase Mutant of Herpes Simplex Virus Type 1 Induces Altered Spectra of Mutations
... exonuclease-negative phenotype of the Pol to revert to that of the proofreading-proficient ...Pol mutant that contained changes within the Exo III motif and the conserved region VI of Pol revealed that it ... See full document
10
Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation in Mice
... With the recent findings of HSV DNA in the CNS of pa- tients dying without encephalitis (2, 43, 68), it became impor- tant to determine whether i.c. injection of G207 might lead to reactivation of or recombination with ... See full document
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Tsg101 Interacts with Herpes Simplex Virus 1 VP1/2 and Is a Substrate of VP1/2 Ubiquitin-Specific Protease Domain Activity
... recombinant virus expressing a C65A mutant VP1/2 also exhibited little differ- ence in single-step growth curves ...a phenotype for these replication parameters, the htUSP activity of VP1/2 on Tsg101 ... See full document
6
Self-association of herpes simplex virus type 1 ICP35 is via coiled-coil interactions and promotes stable interaction with the major capsid protein.
... the herpes simplex virus (HSV) capsid occurs within the nucleus of the infected cell and is a complex process involving the products of at least six viral ...viral protease and assembly ... See full document
12
A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... null mutant that is missing the primary LAT promoter elements between ⫺ 161 and ⫹ ...This mutant is therefore not capable of expressing any LAT RNA (dashed lines) ... See full document
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The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth.
... Phenotypic analysis of mlOO shows that i normal amounts of the c and d forms of ICP35 were produced, but they failed to be processed to the cleaved forms, e and f; ii viral DNA replicati[r] ... See full document
11
Na, an autoproteolytic product of the herpes simplex virus type 1 protease, can functionally substitute for the assembly protein ICP35.
... and ICP35 e,f (VP22a) are described in the ...and ICP35 c,d are indicated by ...and mutant viruses as well as plasmids used for this ...the protease rendering it inactive while leaving the ... See full document
5
Herpes Simplex Virus Type 1 Gene UL14: Phenotype of a Null Mutant and Identification of the Encoded Protein
... The herpes simplex virus type 1 (HSV-1) genome contains 74 different known protein-coding genes (18, ...and mutant phenotypes of most genes have been determined in cell ... See full document
9
Isolation of Herpes Simplex Virus Procapsids from Cells Infected with a Protease-Deficient Mutant Virus
... Herpes simplex virus type 1 (HSV-1) capsid proteins assemble in vitro into spherical procapsids that differ markedly in structure and stability from mature polyhedral capsids but ... See full document
11
Herpes simplex virus type 1 protease expressed in Escherichia coli exhibits autoprocessing and specific cleavage of the ICP35 assembly protein.
... 7362 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The UL26 gene of herpes simplex virus type 1 HSV-1 encodes a protease which is responsible for the C-terminal cleava[r] ... See full document
6
Alterations in Substrate Specificity and Physicochemical Properties of Deoxythymidine Kinase of a Drug-Resistant Herpes Simplex Virus Type 1 Mutant
... Characterization of pyrimidine deoxyribonucleoside kinase thymidine kinase and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 and in c[r] ... See full document
8
Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.
... The UL42 deletion mutant, designated CgalA42, displayed a tight early phenotype in nonpermissive Vero cells producing no infectious progeny, viral DNA, or late gene products but accumula[r] ... See full document
11
Mutant of herpes simplex virus type 1 conditionally able to transform thymidine kinaseless L cells to a tk+ phenotype.
... HSV mutant 1093 to grow in medium selective for the tk+ phenotype Ltk- cells were infected with UV-irradiated KOS 1.1 6, B2006, a tk- mutant of HSV-1 3, Transformed clones/well ata Thymi[r] ... See full document
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