[PDF] Top 20 Phenotypic analysis of bovine papillomavirus type 1 E2 repressor mutants.
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Phenotypic analysis of bovine papillomavirus type 1 E2 repressor mutants.
... Irrespective, the data generated in this study lead to the conclusion that the high excess in the levels of the E2 repressor gene products over the E2 transactivator gene product in mous[r] ... See full document
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Competitive binding of viral E2 protein and mammalian core-binding factor to transcriptional control sequences of human papillomavirus type 8 and bovine papillomavirus type 1.
... viral E2 proteins via the promoter proximal binding sites P2 and BS1, respec- ...these E2 binding sites can reduce basal promoter ...by E2 is due to competitive binding of viral and cellular ...shift ... See full document
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Transcriptional activation function is not required for stimulation of DNA replication by bovine papillomavirus type 1 E2.
... BPV E2 markedly stimulated replication as expected ...full-length E2, because the E2 repressor form (E2TR) was unable to stimulate replication ... See full document
6
Localization and analysis of bovine papillomavirus type 1 transforming functions.
... Mutants deleted of the E6 and E7 ORFs located between the HpaI site base 1 and the SmaI site base 945 are still able to induce transformation, albeit at decreased efficiencies, and the B[r] ... See full document
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Bovine papillomavirus type 1 DNA replication: the transcriptional activator E2 acts in vitro as a specificity factor.
... pSKori 1 (which contains 160 bp of BPV1 DNA sequence, indicated by a continuous black line, spanning the 62-bp minimal ori sequence and carrying the E2 binding site E2BS-12, making up part of the ori ... See full document
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Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation.
... The papillomavirus E1 and E2 open reading frames encode proteins important in the regulation of viral transcription and DNA ...The bovine papillomavirus type 1 (BPV-1) E1 ... See full document
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Targeting the Human Papillomavirus E6 and E7 Oncogenes through Expression of the Bovine Papillomavirus Type 1 E2 Protein Stimulates Cellular Motility
... of E2-expressing cells displayed greater than five protru- sions per cell, while most control cells had 3 to 5 protrusions per cell ...blot analysis and immu- nofluorescence microscopy (see ...by E2 ... See full document
12
Transcriptional and replicational activation functions in the bovine papillomavirus type 1 E2 protein are encoded by different structural determinants.
... the E2 protein and mutants in CHO cells were suffi- cient for the detection of specific gel shift; however, they were difficult to measure by quantitative ELISA using the standard curve obtained with ... See full document
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The bovine papillomavirus type 1 E2 transactivator and repressor proteins use different nuclear localization signals.
... BPV-1 E2 proteins that are required for efficient localization to the ...The E2-TA polypeptide is completely defective for nuclear uptake when a basic region (BR2) in the transactivation domain is ... See full document
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A Novel Silencer Element in the Bovine Papillomavirus Type 4 Promoter Represses the Transcriptional Response to Papillomavirus E2 Protein
... of repressor elements exist: negative regulatory elements (NREs) that are promoter specific and silencer ele- ments that are able to repress heterologous promoter activity out of context of the native ...tional ... See full document
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E1 Protein of Bovine Papillomavirus Type 1 Interferes with E2 Protein-Mediated Tethering of the Viral DNA to Mitotic Chromosomes
... in E2 at residues 298 and 301 by themselves lead to an increase in E2 trans-acting activity in transient assays (12) and increased E2 protein accumulation and a longer half-life for mutant E2 ... See full document
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Functional Interaction of the Bovine Papillomavirus E2 Transactivation Domain with TFIIB
... the papillomavirus E2 protein requires its ; 220-amino-acid amino-terminal transactivation domain (TAD) to interact with cellular factors that lead to formation of an activated RNA polymerase ...The ... See full document
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Isolation of an amino-terminal region of bovine papillomavirus type 1 E1 protein that retains origin binding and E2 interaction capacity.
... amino-terminal E2 interaction domain is cold sensitive was reported previously by Thorner et ...human papillomavirus type 33 E1 by Mu ¨ller and Sapp ...between E2 and E1, E2 binding by ... See full document
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Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB.
... The bovine papillomavirus type 1 (BPV-1) E2 translational open reading frame encodes three proteins that regulate viral transcription and DNA replication: the E2 ... See full document
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Acetylation of Conserved Lysines in Bovine Papillomavirus E2 by p300
... the E2 proteins from several papillo- maviruses (22, 42, ...increase E2-dependent transcrip- ...reduced E2-dependent transcrip- tional ...5 E2 lysine-to arginine-mutants mislocalize. ... See full document
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Inhibition of E2 Binding to Brd4 Enhances Viral Genome Loss and Phenotypic Reversion of Bovine Papillomavirus-Transformed Cells
... the E2 transcriptional activation function is also dependent upon Brd4 and that the Brd4-CTD inhibits this function ...of E2 transcrip- tional activation by Brd4-CTD could contribute to the mor- phological ... See full document
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Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAs.
... 4 0022-538Xl89/041743-13$02.00/0 Copyright C 1989, American Society for Microbiology Bovine Papillomavirus Type 1 Encodes Two Forms of a Transcriptional Repressor: Structural and Functio[r] ... See full document
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Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity.
... These results indicate that the wild-type bovine papillomavirus type 1 genome encodes an E2 repressor protein that moderates the viral transforming activity and allows maintenance of the[r] ... See full document
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Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivator.
... the E2 protein to this assay in- creased the amount of E1 origin-specific binding by ...mutated E2 proteins, and the results from two differ- ent experiments are represented in ...An E2 protein with ... See full document
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Characterization of the Functional Activities of the Bovine Papillomavirus Type 1 E2 Protein Single-Chain Heterodimers
... Three papillomavirus proteins encoded by the bovine papillomavirus type 1 E2 open reading frame have a common C-terminal DNA binding and dimerization domain and function as ... See full document
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