[PDF] Top 20 Phosphorylation regulates human T cell leukemia virus type 1 Rex function
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Phosphorylation regulates human T cell leukemia virus type 1 Rex function
... phosphorylated Rex-1, but also assign phosphorylation to site-specific residues by peptide sequencing using tandem mass ...that Rex-1 is phosphorylated predominantly on serine and ... See full document
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Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo
... of Rex-2 combi- nation ...that phosphorylation of the carboxy terminus of Rex-2 triggers a protein conformation change that is correlated with nuclear localization, protein stability, and ...partial ... See full document
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Phosphorylation of Two Serine Residues Regulates Human T-Cell Leukemia Virus Type 2 Rex Function
... of Rex-2 targeting serine and threonine residues was performed to identify regions or domains within Rex-2 important for function, with a specific emphasis on identifying Rex-2 ... See full document
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Phosphorylation regulates RNA binding by the human T-cell leukemia virus Rex protein.
... Human T-cell leukemia virus (HTLV) type II Rex protein binds specifically to RNA sequences of the HTLV long terminal repeat but poorly to the human immunodeficiency virus type 1 Rev-resp[r] ... See full document
6
The Rex proteins of human T-cell leukemia virus type II differ by serine phosphorylation.
... Endoproteinase digestion and phosphoamino acid analysis of HTLV-ll Rex indicated that p24'x has the same amino acid backbone as p26rx and that the larger apparent molecular size of p26'X[r] ... See full document
5
Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.
... Due to the multiva- lent transdominant capacity to inhibit both the HTLV-I rex and the HIV-1 rev gene function on both RNA target sequences (RxRE and RRE), the mutant protein encoded in [r] ... See full document
8
Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.
... in human T-cell leukemia virus type 2 (HTLV-2)-infected ...exons 1, 2, and 3 produces the essential posttranscrip- tional regulator Rex; shorter 1-3 and ... See full document
9
Rex transregulation of human T-cell leukemia virus type II gene expression.
... Deletion and substitution mutagenesis of the Rex11RE permitted identification of a small subregion within the larger element critically required for Rex-II responsiveness and further sug[r] ... See full document
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Functional Domain Structure of Human T-Cell Leukemia Virus Type 2 Rex
... The Rex protein of human T-cell leukemia virus (HTLV) acts posttranscriptionally to induce the cytoplasmic expression of the unspliced and incompletely spliced viral RNAs ... See full document
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Nuclear Export and Expression of Human T-Cell Leukemia Virus Type 1 tax/rex mRNA Are RxRE/Rex Dependent
... of Rex, tax/rex RNA was exported to the cytoplasm less efficiently, result- ing in smaller amounts of Tax protein ...as Rex had no effect on the same cDNA when the 3=-LTR sequence was re- placed by ... See full document
7
Human T-Cell Leukemia Virus Type 2 Rex Carboxy Terminus Is an Inhibitory/Stability Domain That Regulates Rex Functional Activity and Viral Replication
... active Rex-2 mutants, A157D and S158Term, led to increased pro- duction of p19 Gag as measured in the culture supernatant, ultimately increasing HTLV-2 infectious spread and HTLV-2- mediated cellular proliferation ... See full document
12
Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1
... HIV type 1 Env protein in the presence of a functional Rex ...kit. Human anti-HIV antisera diluted 100-fold were added to the wells of the plate, and the plate was ...The cell lysates ... See full document
6
The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells.
... normal T-cell activation and growth. Rex acts at the post- transcriptional level by promoting the nucleocytoplasmic ex- port and hence the translation of unspliced and singly spliced mRNAs that ... See full document
8
High-resolution mapping of the human T-cell leukemia virus type 1 Rex-binding element by in vitro selection.
... the Rex ARM are localized within these ...the Rex ARM, while the right half of the XBE, spanning residues 174 to 179 and 201 to 204, forms a sequence-specific TAR-like arginine-binding ... See full document
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Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo.
... Of note, the Rex-Rex interaction occurring in trans appeared quite stable, as the level of CAT activity obtained was consistently greater than one-third of that measured with the GAL4-VP[r] ... See full document
7
Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange.
... The human retroviruses human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I) are characterized by complex regulation of gene expression.. Each virus[r] ... See full document
5
Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals.
... Interaction of the human immunodeficiency virus type I Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids[r] ... See full document
5
Phosphorylation of Human Immunodeficiency Virus Type 1 Vpr Regulates Cell Cycle Arrest
... (Fig. 1). The loss of Vpr G 2 cell cycle arrest in our mutants could be due to mutation of the phosphorylation site, S79, or effects on phosphorylation by mutations in the adjacent ...2 ... See full document
8
Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax.
... Evidence for phosphorylation of trans-activator p4Ox of human T-cell leukemia virus type I produced in insect cells with a baculovirus expression vector. HTLV-1 associated myelopathy, a [r] ... See full document
6
APOBEC3G targets human T cell leukemia virus type 1
... anti-HTLV-1 function of APOBEC3G and first description of possible involve- ment of other mechanisms than inducing G-to-A hyper- mutation in anti-HTLV-1 ... See full document
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