[PDF] Top 20 Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals
Has 10000 "Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals" found on our website. Below are the top 20 most common "Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals".
Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals
... exhibit neutralization breadth (4, 7, 37, 39, 41, ...MPER neutralization may feature more prominently in plasma sam- ples that exhibit somewhat weaker overall neutralization ...the ... See full document
18
HIV 1 immunogens and strategies to drive antibody responses towards neutralization breadth
... circulating HIV-1 ...target epitopes on Env have been insufficient to focus the immune system towards more conserved epitopes and induce neutralization ...bNAb epitopes ... See full document
11
Evidence for Similar Recognition of the Conserved Neutralization Epitopes of Human Immunodeficiency Virus Type 1 Envelope gp120 in Humans and Macaques
... immune responses to the HIV-1 envelope in humans and macaques by assessing the ability of HIV-1 and SHIV antisera to neutralize isogenic V3 loop glycan-possessing and -deficient ... See full document
10
HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
... of HIV-specific CD4 ⫹ T cells in the develop- ment of antibody neutralization breadth, we comprehensively as- sessed a cohort of 34 chronically HIV-infected controllers for cir- culating ex ... See full document
13
Anti MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV 1 infected individuals
... humoral responses, which also include several anti- bodies with low or null neutralizing capacity ...MPER responses in HIV-1 infected ...MPER epitopes recognized by 2F5 and 4E10 ... See full document
12
Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals
... the infected cell surface ...the infected cell ... 1 subunit of host adaptor protein 1 (AP1) (28) while the HIV-1 accessory protein Vpu downregulates HLA-C ...that ... See full document
19
Comparative Immunogenicity of Subtype A Human Immunodeficiency Virus Type 1 Envelope Exhibiting Differential Exposure of Conserved Neutralization Epitopes
... of neutralization against heterolo- gous subtype A or B Envs ...from HIV-1-infected individuals and to monoclonal antibodies (6), raising the pos- sibility that the poor breadth ... See full document
12
Evolutionarily Conserved Epitopes on Human Immunodeficiency Virus Type 1 (HIV-1) and Feline Immunodeficiency Virus Reverse Transcriptases Detected by HIV-1-Infected Subjects
... (CTL)-associated epitopes, evolutionarily conserved on both HIV type 1 (HIV-1) and feline immunodeficiency virus (FIV) reverse transcriptases (RT), were identified using gamma ... See full document
12
Comparison of Human Immunodeficiency Virus (HIV)-Specific T-Cell Responses in HIV-1- and HIV-2-Infected Individuals in Senegal
... in HIV-1 and HIV-2 infection that confer enhanced viral control, we examined responses in 123 untreated Senegal- ese patients with either HIV-1 or HIV-2 ...T-cell ... See full document
9
Differential Antibody Responses to Conserved HIV 1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native Like gp140 Trimers
... A subset of antigens was then selected for ...antibody responses, while deep sequencing provided further insights into the mouse splenic B-cell repertoires primed by the tested ...robust ... See full document
26
Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes
... type 1 (HIV-1) vaccine ...antigen-specific cell sorting of mem- ory B cells (6, 7) and improved culture methods for single B cells (8–11), together with genetic recovery of ... See full document
13
Epitopes Immediately below the Base of the V3 Loop of gp120 as Targets for the Initial Autologous Neutralizing Antibody Response in Two HIV-1 Subtype B-Infected Individuals
... both individuals at these time points. B cells were inoculated with Epstein-Barr virus (EBV; strain B95-8) and plated at low cell densities in multiple 96-well tissue culture plates containing ... See full document
14
Characterization of T-Cell Responses to Conserved Regions of the HIV-1 Proteome in BALB/c Mice
... type 1 (HIV-1)/AIDS continues ...that HIV- 1-specific CD8 ⫹ T cells contribute to the control of HIV-1 repli- cation during acute and chronic stages of infection by ... See full document
8
Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes
... T cell recognition of 12 conserved or cross-reactive ...13 epitopes in this cohort. The data for reported clade B sequences in the Los Alamos database and our cohort are shown in ...13 ... See full document
10
Abnormal B cell memory subsets dominate HIV specific responses in infected individuals
... Although HIV does not produc- tively infect B cells, numerous phenotypic and functional abnor- malities of B cells have been described in HIV disease (21, ...ongoing HIV replication ... See full document
12
HIV-1 Subtype C-Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes
... antibody responses to the gp120-gp41 interface, including the fusion ...in neutralization of ...for neutralization in panel A are shown in red, blue represents ELISA-positive samples where FP9 did ... See full document
17
Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV resistant prostitutes in Nairobi
... CTL epitopes for a range of HLA types (13), these have largely been defined in Western cohorts consisting predominantly of Caucasians in- fected with clade B ...CTL epitopes makes it likely that some ... See full document
9
Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals
... clade B gp120 proteins used for adsorption analysis were based on clade B strains BaL and ...significant neutralization activity (Table 1) against heterolo- gous clade B isolates and ... See full document
15
Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+-T-Cell Responses for Groups of HIV-1-Infected Individuals with Different HLA-B*35 Genotypes
... early HIV or simian immunodeficiency virus gene products, such as Nef and Tat, are the most effective (1, 12, 13, 19, 26), because these CTL recognize and kill virus-infected cells before viral ... See full document
8
Anal Invasive Squamous Cell Cancer and Human Papillomavirus Distribution in HIV Infected and Non HIV Infected Individuals
... squamous cell cancer (SCC) of the anal canal and perianal region. HIV infection is a key risk factor for anal SCC owing to the high risk of con- tracting coinfections with HPV [5] [6] [9] ...among ... See full document
7
Related subjects