[PDF] Top 20 Predicting the Impact of CD8+ T Cell Polyfunctionality on HIV Disease Progression
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Predicting the Impact of CD8+ T Cell Polyfunctionality on HIV Disease Progression
... polyfunctional CD8 ⫹ T cell response is the cause of better viral control, there are still concep- tual issues to be ...polyfunctional CD8 ⫹ T cells within the HIV-1-specific ... See full document
12
Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8+ T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression
... activated/exhausted T cells and mono- cytes (13, ...inhibiting T cell responses to tumor antigen in vitro and in vivo ...the cell surface by matrix metalloproteinases ADAM10 and ADAM17, ... See full document
14
Dendritic Cells Restore CD8+ T Cell Reactivity to Autologous HIV-1
... tionally, HIV-1 was isolated from CD4 ⫹ T cells at one post-cART time point in subjects S2 and ...isolate HIV-1 from CD4 ⫹ T cells in subject S8, potentially due to the low HIV-1 load ... See full document
15
Genome wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease
... the disease progression [12]. In HIV disease progres- sion, numerical decline and functional impairment of CD8+ T cells can be attributed to increased susceptibility to apoptosis ... See full document
21
Early HLA-B*57-Restricted CD8+ T Lymphocyte Responses Predict HIV-1 Disease Progression
... of HIV-1 infection, the MACS is an ongoing prospective cohort study of men who have sex with men that operates at four sites within the United States of America (19, 20, 22, ...⫹ T cell count, ... See full document
12
Dynamics of Naive and Memory CD4+ T Lymphocytes in HIV 1 Disease Progression
... + T-cell subsets de- cline, CD8 + naive cell numbers increase slightly and CD8 + memory cell numbers increase dramatically to compensate and maintain T-cell ... See full document
18
Impact of HAART on T Cell activation in HIV-Infected Adolescents
... in HIV- positive adolescents. We assembled a cohort of 35 HIV-infected and 12 healthy adolescents and measured immune activation (CD38,CD38/HLA-DR, Ki67) in both baseline and longitudinal ...expected, ... See full document
127
Differential Impact of Magnitude, Polyfunctional Capacity, and Specificity of HIV-Specific CD8+ T Cell Responses on HIV Set Point
... of HIV replication is critical for designing an HIV vaccine capable of eliciting such a response ...of CD8 ⫹ gamma interferon (IFN- ␥ ) T cell responses to HIV failed to ... See full document
6
Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression
... persisting HIV-specific T cells in this study, suggesting that the fluctuations we observed for many of the persisting responses were due to mechanisms other than viral ...the CD8 ⫹ ... See full document
12
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
... precedes disease or is merely a consequence of time and disease duration has important implications for disease mechanisms, monitoring, and ...chronic HIV infection (59), consistent with ... See full document
12
Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages
... to cell signaling, CD3epsilon expression on CD4+ T cells was found to be significantly lower in the VIR group than in LTNP, which indicates that the expres- sion level of CD3epsilon can be used to ... See full document
13
HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses
... tuberculosis progression from latent tuberculosis in- fection (LTBI) to tuberculosis disease ...aviremic HIV- infected individuals remained at higher risk of developing TB than HIV-uninfected ... See full document
18
Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype
... For instance, the B57TW10 response resulted in complete escape early in infection, while the B08FL8 response resulted in 50% escape by 2 years (6). The B57/58KF11 response, with its 97% conservation score and its ... See full document
8
Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome
... primary HIV-1 infection have been shown to be critical for the subsequent rate of disease ...of HIV-specific CD8 T cell ...particular HIV-specific CD8 T ... See full document
9
The impact of heart on CD4 and T cell count in patients with adult HIV disease
... control HIV infection is that the CD4 + T helper cells are the target of the ...to HIV, which occurs from the very beginning of infection and is ...AIDS CD8 + cells also decline ... See full document
60
HIV infection induced posttranslational modification of T cell signaling molecules associated with disease progression
... and CD8 1 T cells isolated from symptomatic HIV and AIDS patients and individuals in both acute and early stages of HIV infection ...of HIV symptomatic/AIDS pa- tients (data not ...in ... See full document
9
Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
... HIV-specific CD8 T cells from high Gag responders exhibit a more polyfunctional cytokine ...the HIV-specific T-cell re- sponses with highest functionality are inversely ... See full document
10
The functional CD8 T cell response to HIV becomes type specific in progressive disease
... CD4 T cell targets infected with lab-strain and autologous HIV decline with disease ...progression. HIV-infected CD4 T cells rapidly downmodulate CD4 expression, so ... See full document
10
Monocyte glycolysis determines CD8+ T cell functionality in human Chagas disease
... Chagas disease, also known as the “silent” ...Chagas disease is currently based on 2 compounds, nifurtimox and benznidazole, which have sub- stantial activity in congenital and acute ...the disease, ... See full document
17
Altered representation of naive and memory CD8 T cell subsets in HIV infected children
... CD8 T cells are divided into naive and memory subsets according to both function and ...In HIV-negative children, the naive subset is present at high frequencies, whereas memory cells are virtually ... See full document
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