[PDF] Top 20 IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
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IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
... of HIV-negative and HIV-positive subjects to pp65+IE-1 or Gag+Env ...20 HIV-negative or 19 HIV-positive subjects) of the absolute number of cells for each of the 32 pheno- types, as ... See full document
14
Type I Interferon Signaling Enhances CD8+ T Cell Effector Function and Differentiation during Murine Gammaherpesvirus 68 Infection
... cytokine production in IFNAR1 ⫺/⫺ CD8 ⫹ T cells throughout later time points suggested possible ongoing interference with CD8 ⫹ T cell ...of CD8 ⫹ T ... See full document
10
CD27 and CD57 Expression Reveals Atypical Differentiation of Human Immunodeficiency Virus Type 1-Specific Memory CD8+ T Cells
... ⫹ HIV-1-specific (median, 83%; range, 40 to 96%) and the CD27 ⫹ EBV-specific CD8 ⫹ T cells (median, 85%; range, 63 to 93%) (P ⬍ ...between HIV-1-specific (for CD28, ... See full document
7
CD4+ T-Cell Help Enhances NK Cell Function following Therapeutic HIV-1 Vaccination
... NK cell responses to HIV-1 Gag correlate with IL-2 ...of T-cell help for NK cell function in HIV-1 infection, we initially investigated the impact of ... See full document
6
Expansion of Polyfunctional HIV-Specific T Cells upon Stimulation with mRNA Electroporated Dendritic Cells in the Presence of Immunomodulatory Drugs
... of HIV- specific CD8 ⫹ T-cell responses indicate that these drugs are prom- ising candidates to enhance the efficacy of DC-based HIV vac- ...polyfunctional ... See full document
10
Phenotypic and Functional Characterization of Circulating Polyomavirus BK VP1-Specific CD8+ T Cells in Healthy Adults
... lion cells per well were stimulated with PMA (10 ng/ml) and ionomycin (1 g/ml) or with the viral peptides in culture medium in the presence of anti-CD107a FITC (eBioscience), ␣ CD29 (TS2/16, 1 g/ml), brefeldin ... See full document
10
Response to Superantigen Stimulation in Peripheral Blood Mononuclear Cells from Children Perinatally Infected with Human Immunodeficiency Virus and Receiving Highly Active Antiretroviral Therapy
... from HIV-infected children receiving treatment with highly active antiretroviral therapy ...cytokine production, and activation antigen upregulation in CD4 and CD8 T lymphocytes following in ... See full document
6
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
... uncouples T cell proliferation from differentiation and preserves antitumor efficacy in ...optimal T cell populations for ACT are early effector cells that retain high ... See full document
12
Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens
... IFN production (RIG-I and MDA-5), revealing that the innate immune responses are en- hanced by selective deletion of the VACV N2L gene and confirm- ing the role of the VACV N2 protein in blocking the IFN-I signal- ... See full document
19
Interleukin-21-Producing HIV-1-Specific CD8 T Cells Are Preferentially Seen in Elite Controllers
... of HIV-1-specific IL-21 ⫹ CD4 T cells following primary infection (6, ...analyzed IL-21 directly by flow cytometry were unable to show signifi- cant differences in the induction ... See full document
9
Interleukin-1R Signaling Is Essential for Induction of Proapoptotic CD8 T Cells, Viral Clearance, and Pathology during Lymphocytic Choriomeningitis Virus Infection in Mice
... LCMV-specific CD8 T cells from IL-1R ⫺/⫺ mice did not express any granzymes, the absence of apoptotic activity against MEF and EL4 target cells, respectively, was not surprising ... See full document
7
Influenza A Virus Infection in Pigs Attracts Multifunctional and Cross-Reactive T Cells to the Lung
... influenza-evoked T-cell ...systemic T-cell response in influ- enza virus-infected pigs, addressing kinetics and phenotype as well as multifunctionality (gamma interferon [IFN- ␥ ], tumor ne- ... See full document
19
HIV specific CD8+ T cells and HIV eradication
... (Figure 2). Faced with the challenge of achieving HIV eradication, we do, however, draw considerable inspiration from the other precedents that illustrate the power of a cellular immune response that has ... See full document
10
Abrogating Cbl b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice
... restored IL-2 production and autocrine proliferation in the absence of exogenous IL-2, functions that could likely render these genetically modified tumor-reactive cells more ... See full document
14
Anti-Inflammatory Cytokines Directly Inhibit Innate but Not Adaptive CD8+ T Cell Functions
... antigen-specific T cells ...enabling CD8 ⫹ T cells to better respond to signals such as IL-2, which is likely to be generated near a site of active ... See full document
11
Immune Activation Is Associated with CD8 T Cell Interleukin-21 Production in HIV-1-Infected Individuals
... of IL-21- producing CD8 T cells with CD4-like characteristics, we evaluated their ability to upregulate CD40 ligand (CD40L) upon stimula- ...between IL-21-producing CD8 and CD4 ... See full document
5
Role of IL 17 in HIV specific CD8+T cell immunity
... Data indicated that compared to the control vaccine, IL-13 inhibitor vaccine showed enhanced IL-17 A expression by HIV -specific CD8+T cells at effector stage and following surrogate inf[r] ... See full document
202
HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function
... Because IL-21 ⫹ CD4 ⫹ T cells are major contributors to control in the setting of LCMV infection through the modu- lation of virus-specific CD8 ⫹ T cells and because these ... See full document
9
Epitope Mapping of HIV-Specific CD8+ T Cell Responses by Multiple Immunological Readouts Reveals Distinct Specificities Defined by Function
... of cell- mediated immunity (CMI) responses that may be capable of controlling ...stronger HIV-specific CD8 ⫹ T cell pro- liferation than do progressing controls (11, 30, ... See full document
12
Weak anti HIV CD8+ T cell effector activity in HIV primary infection
... 300–1,000 cells with 50 ng/mL PMA and 500 ng/mL ...of cells cultured in medium alone or with irrelevant peptides ...plated cells. Frequencies of IFN-γ spot-forming cells (SFC) were then ... See full document
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