[PDF] Top 20 Prognostic role of hypoxia-inducible factor-1 alpha expression in osteosarcoma: a meta-analysis

... α expression with age, chemotherapy response, tumor size, and tumor ...of osteosarcoma should be performed to derive more accurate ...the expression of HIF-1 α in the included studies was ... See full document

... 9]. Hypoxia-inducible factors (HIFs) have severed as the critical molecular mediators in response to ...to hypoxia-response elements (HREs) regulating the transcription of many genes relevant to ... See full document

... α expression in normal breast tissue was compared with that in different pathological stages of breast ...important role in tumorigenesis ...α expression in breast cancer are scarce and controversial ... See full document

... factors. Hypoxia-inducible factor-1 alpha (HIF-1 α ) is the key regulator of an- giogenesis in hypoxia, which directly and indirectly affects angiogenesis by influencing ... See full document

... (RAEB 1, n=21), refractory anemia with excess blast-2 (RAEB 2, n=18) and del(5q) syndrome (5q-, ...International Prognostic Scoring System (IPSS), patients were divided into a low-risk group (IPSS score =0, ... See full document

... [2,3]. Hypoxia inhibits this process, resulting in upregulation of HIF-1 α and its downstream target genes ...hand, hypoxia-independent upregulation of HIF- 1 α may be accomplished by loss of ... See full document

... Background: Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that plays a central role in biologic processes under hypoxic conditions, especially ... See full document

... critical role in hypoxia to improve glycolysis, oxygen delivery, and angiogenesis for tumor cells ...HIF1α expression and HIF1α signal pathway in tumor microenvironment may serve as a key ... See full document

... with lung cancer, whereas these two polymorphisms showed no significant association with prostate cancer. In oral squa- mous cell carcinoma (OSCC) subgroup analyses data showed that only 1790 G/A polymorphism has ... See full document

... one-way analysis of variance (ANOVA) with Tukey’s adjustment to compare three or more groups (for ex- ample, different treatment types, time points, and so on); and 3) a two-way ANOVA with Bonferroni ad- justment ... See full document

... the role of epithelial HIF-1 and its target genes in renal ...HIF-1α expression was associated with the degree of fibrotic injury in renal biopsy tissues from patients with ...the expression ... See full document

... early prognostic biomarkers is urgently needed to adapt the proper therapy to the ...high expression of certain cell surface markers indicates bad clinical features and poor progno- sis, and CD44V6 is one ... See full document

... the expression of the hypoxia-inducible factor 1 alpha ...protein expression in an oxygen independent manner in a panel of cancer cell ...protein expression by ... See full document

... involves inhibition of HIF-1α, VEGF, and PHD2 expression to regulate multiple hypoxic and angiogenic genes. A previous study reported that dual inhibition of VEGF receptor and angiopoietin-2 could prolong the VN ... See full document

... differential expression. After dimerization between HIF-α and HIF-β, dozens of hypoxia responsive genes (HRGs) can be ...from hypoxia, causing increased stability of intracellular HIF-α, which can ... See full document

... carotid artery, triggering electrical signaling of the central nervous system to affect breathing and arterial tone [43 López-Barneo 1988]. Another such oxygen-sensitive response is the upregulation of erythropoietin ... See full document

... Chromatin DNA was sheared to a size of 200–1,000 bp in a chilled sonificator. Primary antibodies for HIF-1 α or protein A IgG were then added to precipitate the DNA–transcription factors complex. The precipitate ... See full document

... follows: 1) study type: randomized controlled trials, randomized crossover studies, and prospective studies; 2) study subjects: patients who met the diagnostic criteria only for anemia of CKD, regardless of race; ... See full document

... The OS time in the low-expression group was significantly shorter than that in the high- expression group. The median survival of HES1- low group was 54±1.3 months, while that of HES1-high group was 70±1.5 ... See full document

... Pancreatic cancer remains one of the most lethal of all human malignancies with its incidence nearly equaling its mortality rate. Therefore, it’s crucial to identify newer mechanism-based agents and targets to ... See full document