[PDF] Top 20 A proinflammatory role for IL 18 in rheumatoid arthritis
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A proinflammatory role for IL 18 in rheumatoid arthritis
... of IL-18 to promote NO production in syn- ovial membrane ...vs. IL-18 14 ± ...cocktail, IL-18/IL-12/IL-15 (29 ± ...with IL-18 alone (P = 0.03). ... See full document
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Decreased response to IL 12 and IL 18 of peripheral blood cells in rheumatoid arthritis
... the IL-1 family [14]. IL-18 stimulates the synthesis of IFN-γ in T cells and natural killer (NK) cells, leading to the development of Th1-type immune ...addition, IL-18 also activates ... See full document
7
Elevated Level of Interleukin-29: A Proinflammatory Role in Synovial Inflammation of Rheumatoid Arthritis
... important role in the pathogenesis of ...of IL-29 and its receptors IL-28Rα in blood and synovial fluid (SF) in RA patients and investigate the correlation of IL-29 with disease activity and ... See full document
5
Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients
... TNF-α, IL-8, GM-CSF and IL-6) in RA-FLS stimulated by recombinant ...VEGF, IL-8, GM-CSF and IL-6 (Fig. 4A), but not those of PDGF, bFGF, IL-1β or TNF-α (data not ... See full document
13
Interleukin 37 is increased in adult onset Still’s disease and associated with disease activity
... 1β, IL-6, IL-18, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ), have been found to be elevated during AOSD and are thought to be involved in the pathogenesis of AOSD ...[8–13]. ... See full document
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Cytokine mRNA and protein expression in primary culture and repeated passage synovial fibroblasts from patients with rheumatoid arthritis
... [7], IL-6 [8], and IL-8 ...including IL-10 [10], IL-13 [11], IL-15 [12], and IL-18 [1,13], although these have appeared to be less ...particular IL-6 [14], ... See full document
11
Expression of interleukin 18 receptor in fibroblast like synoviocytes
... the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates ... See full document
8
Cells of the synovium in rheumatoid arthritis Macrophages
... pro-inflammatory role of IL-18 in arthritis (and its potential suitability as a therapeutic target in RA) is indicated by the following findings: (a) IL-18 treatment markedly ... See full document
16
Role of Interleukin 1 Alpha (IL 1α) and Interleukin 1 Receptor Antagonist (IL 1RA) in Pathogenesis of Juvenile Idiopathic Arthritis and Adult Onset Rheumatoid Arthritis of Iraqi Patients
... The role of IL-1α in the pathogenesis of JIA was not well- defined in the present study, especially if we notice that its serum level in patients represented about 50% of IL-1α level in controls; ... See full document
7
Skewed distribution of proinflammatory CD4+CD28nullT cells in rheumatoid arthritis
... of IL-17, and recent publications have further shown that IFN-γ counteracts the dif- ferentiation of IL-17-producing T cells ...not IL-17 [6,30], it ... See full document
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Genetic polymorphisms in tumour necrosis factor receptors (TNFRSF1A/1B) illustrate differential treatment response to TNFα inhibitors in patients with Crohn’s disease
... Introduction Tumour necrosis factor-α TNFα is a proinflammatory cytokine that has been found to be dysregulated in numerous inflammatory disorders including rheumatoid arthritis, psorias[r] ... See full document
10
Promotion of osteoclastogenesis by IL 26 in rheumatoid arthritis
... of IL-26 in RA pathogenesis are poorly ...that IL-26 mainly expressed by synovial cells induces the produc- tion of proinflammatory cytokines (IL-1-β, IL-6, and TNF-α) by myeloid cells ... See full document
13
CD14brightCD16+ intermediate monocytes are induced by interleukin 10 and positively correlate with disease activity in rheumatoid arthritis
... cytokine IL-10, which is increased in patients with RA, induces CD16 expression on mono- ...a role in the pathogenesis of RA, and that IL-10 is a key cytokine in the regulation of CD16 ... See full document
10
Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis
... were found in patients with active RA [10]. However, be- cause the CD14 ++ CD16 + and CD14 + CD16 ++ subsets over- lap when they are defined solely by the presence of CD14/ 16 expression, an unequivocal discrimination is ... See full document
10
Glial contributions to neurodegeneration in tauopathies
... nuanced role in neuroprotection and mainten- ance of ...of proinflammatory cytokines including interleukin (IL) 1-beta (IL-1β), tumor necrosis factor alpha (TNF-α), IL-6, ... See full document
16
Interleukin 7 deficiency in rheumatoid arthritis: consequences for therapy induced lymphopenia
... that IL-7 drives the survival and proliferation of human T- cells after lymphodepletion (for review ...[8-10]. IL-7 produced in response to lymphopenia stimulates prolifera- tion of both naïve and memory ... See full document
13
Original Article Circulating lnc-ITSN1-2 expression presents a high value in diagnosis of rheumatoid arthritis and correlates with disease activity
... induced arthritis (AA) and normal rats by lncRNA/mRNA microarray, and six lncRNAs con- sisting of XR_008357, U75927, MRAK04- 6251, XR_006457, DQ266363 and MRAK00- 3448 are further validated to be increased in AA ... See full document
8
BIOLOGICS: ROLE IN RHEUMATOID ARTHRITIS
... produces IL-6 causes T-cell ...for IL-6 inhibitor. It acts on both soluble and membrane bound IL-6 receptors and it inhibits IL-6 mediated signaling through these receptors 3 ...in ... See full document
9
Interleukin 29 modulates proinflammatory cytokine production in synovial inflammation of rheumatoid arthritis
... Human IL-29 ELISA reagent kits were purchased from Adlitteram Diagnostic Laboratories (San Diego, CA, ...anti-human IL-29/IL-28Ra polyclonal antibody, and mouse anti-human CD68 monoclonal antibody ... See full document
10
Heterogeneous expression pattern of interleukin 17A (IL 17A), IL 17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti IL 17 therapy?
... the proinflammatory cytokine interleukin 17 (IL-17) and represent a distinct subset of CD4+ cells characterised by the expression of Retinoic acid receptor–related or- phan receptor γt (RORγt) ...of ... See full document
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