[PDF] Top 20 Quantifying heterogeneity in individual participant data meta-analysis with binary outcomes

... of meta-analytic ...inter-study heterogeneity of those effects is also an important ...analyzing data from ...of binary outcomes do not report any measure of heterogeneity ... See full document

... the meta- analyses using the primary trial IPD available. These IPD meta-analyses will be conducted using a one-step ap- proach, where the IPD from all studies are modeled sim- ultaneously while accounting ... See full document

... providers, data collectors, outcome adjudicators, and data analysts; proportion of participants with available data; and stopping early for bene fi ...of outcomes in published protocols and in ... See full document

... follow-up data provided from the individual trials to ensure internal consistency and consistency with published reports and to assess missing data, using pub- lished data, trial protocols, ... See full document

... The cited reviews only included studies that were published over a decade ago, the most recent studies investigating German rehabilitation programmes were not included. Additionally, in 1996 a systemic legal change ... See full document

... de-identified individual participant data (IPD) on stroke outcomes up to 5 years after ...stroke. Outcomes included mortality (date, time of stroke, date of death), functional ... See full document

... generating heterogeneity on the intercept and/or the smoker’s effect would not have altered our re- sults and our ...of heterogeneity in the interaction term, as that would have combined the statistically ... See full document

... no heterogeneity of overall treat- ment effects or interactions, the same number of patients in each treatment group within a trial, and same residual variances in all ...non-continuous outcomes ... See full document

... raw data (see Additional file 3 for contact letter, a modified version of ...and outcomes as well as a short description of the ACT-CP-MA ...their data to become a co-author in the result ...study ... See full document

... considerable heterogeneity across studies was ...examine heterogeneity, the I 2 -statistic was ...of heterogeneity expressed as a percentage: an I 2 value of 0% is interpreted as no ... See full document

... (FE) meta-analysis methods (which assume that individual studies are estimating the same underlying treatment effect) and random effects (RE) methods (which assume that different studies are ... See full document

... reported data from an original research study, (2) fo- cused on patients with GD, (3) evaluated plasma chito- triosidase activity, (4) evaluated serum CCL18 level, and (5) captured one or more pre-specified ... See full document

... the outcomes a one stage approach to analysis will be taken so that the IPD from all eligible trials are included in a single ...assess heterogeneity of treatment effect across ...statistical ... See full document

... group was quite similar in the three studies. Other dif- ferences between the three studies, including the lower rate of VAP in control group, and the higher percent- age of patients with chronic respiratory disorders in ... See full document

... Aggregated data meta-analysis involves synthesis of esti- mates from clinical ...aggregated data meta-analyses is that primary outcomes of clinical trials as well as sub- groups ... See full document

... Eligible study designs included cohort as well as case control studies published in English, French, Spanish, and German, and must have reported IPD on pregnancy as a risk factor for influenza-associated mortality ... See full document

... a meta-analysis, whereas if it is to avoid providing trials of poor quality, then not including these trials might make a meta-analysis more ...IPD meta-analyses included less than 80% ... See full document

... with binary outcomes [4, 15], that is, when the number of studies and the number of subjects within each study is small, study sizes are imbalanced, in the presence of large between-study ... See full document

... multilevel binary logistic mixed effects models to examine the associations of these pregnancy complications with the risk of childhood underweight, overweight and obesity in the same age ...missing data on ... See full document

... We found that more than half (73%) of studies did not use a two-step approach (i.e. analyzing each study separ- ately and as identically as possible and pooling via stand- ard meta analytic methods) but instead ... See full document