[PDF] Top 20 Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function
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Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function
... type 2 diabetes include cochlear microangiopathy, degeneration of the stria vascularis and outer hair cells ...type 2 diabetes on hearing ...as 2 months after induction of type 2 diabetes in ... See full document
10
Hippo mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer
... (PTEN) or the protein kinase Hippo signaling pathway induces liver cancer via activation of AKT or the transcriptional regulators YAP/TAZ, respectively; however, the potential for crosstalk between the PTEN/AKT and ... See full document
17
Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population
... codon 1057 in IRS-2 and DM are potent risk factors for CAD (Table 3). Importantly, we found that the concur- rence of Gly allele with DM is associated with an increased susceptibility to CAD (Table 4). In patients ... See full document
8
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... and function of chromatin ...HDAC1, 2, 3 and 8, are the known members of class I deacetylases ...and 2 are the best characterised, and are chief constituents of the multiprotein ... See full document
14
The role of insulin receptor substrate 2 in hypothalamic and β cell function
... Through global gene deletion, we and others have previously implicated Irs2 in the regulation of β cell function and peripheral glucose metabolism and the central regulation of energy homeostasis (10, 11, 19, 22). ... See full document
12
Mosaic analysis of insulin receptor function
... Necroscopic and histologic analyses revealed the com- plete absence of mature adipocytes in the interscapular (BAT), subcutaneous, and epididymal (white adipose tis- sue, EWAT) regions of both subsets of mice. To ... See full document
12
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... cell loss and replacement fibrosis in CIRS12KO hearts after aa treatment relative to saline- treated controls (Figure 5, F and ...contractile function (Figure 5H and Supplemental Table ... See full document
16
<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... This study included 583 patients with MDD and 564 healthy controls. Demographic characteristics of our parti- cipants are presented in Table S1. As shown in Table S1, female participants were about twice as likely as ... See full document
7
PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ... See full document
12
Altered function of insulin receptor substrate 1–deficient mouse islets and cultured β cell lines
... Type 2 diabetes is characterized by peripheral insulin resistance followed by a failure of compensation by the pancreatic β cell and, ultimately, frank hyperglycemia (21, ...the insulin-signaling ... See full document
8
Original Article Insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism is associated with colorectal cancer susceptibility: a meta-analysis involving 11,234 subjects
... have insufficient power to obtain a conclusive result, probably due to certain limitations such as small sample size. Meta-analysis is consid- ered a powerful way for pooling the conflicting findings from different ... See full document
10
Tyrosine kinase signalling in breast cancer: Insulin like growth factors and their receptors in breast cancer
... that insulin receptor may mediate the IGF-II response in breast cancer ...addition, insulin receptor–IGF1R hybrids are over- expressed in breast cancer, and these receptors can also mediate ... See full document
6
Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice
... Moreover, insulin and insulin-like growth factor cellular signaling were differen- tially altered in ovarian cells from women with PCOS, but after TZD treatment cell signaling was similar to cells from ... See full document
8
Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer
... As the previous experiments were all performed using murine models, we explored the effect of IRS1 and IRS2 on ErbB2 signaling in human immortalized non- transformed human mammary epithelial cells (MCF10A) which ... See full document
7
Insulin receptor signaling in the development of neuronal structure and function
... Imaging optic tectal neurons in vivo in Xenopus tadpoles showed that dendritic arbor elaboration goes through distinct phases (Figure 2A) [19,48]. Many newly differ- entiated neurons first undergo axonogenesis with only ... See full document
18
Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ... See full document
15
Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... Insulin receptor substrates (IRS-1 and -2) are essential for intracellular signaling by insulin and IGF-I, anabolic regulators of bone ...with insulin or IGF-I failed to induce tyrosine ... See full document
10
Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins
... Western blot analysis. Immunoprecipitates were washed three times with phosphate-buffered saline containing 1% Triton X-100, 0.5% deoxycholic acid, and 0.1% sodium dodecyl sulfate, resuspended 1:2 in Laemmli ... See full document
9
Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes
... especially insulin resistance [12]. Individuals with insulin resistance may produce suffi- cient insulin, but can ’ t effectively reduce blood sugar level because of resisting the function of ... See full document
8
Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... immunoprecipitates was decreased by 79.5 +/- 11.2% (P < 0.02). In muscle, the changes were less dramatic, and often in opposite direction of those observed in liver. Thus, there was no significant change in ... See full document
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