[PDF] Top 20 Regional citrate versus heparin anticoagulation for continuous renal replacement therapy in critically ill patients: a meta analysis with trial sequential analysis of randomized controlled trials

... Previous meta-analyses evaluating this topic have been ...published meta-analyses. First, this meta-analysis included an add- itional eight trials performed since ...Chinese ... See full document

... of meta-analyses evaluating timing of RRT initiation in AKI and patients outcomes AKI acute kidney injury, CRRT continuous renal replacement therapy, ICU intensive care unit; IHD ... See full document

... adult critically ill patients, where SUP with PPI or H2RA was compared to placebo or no prophylaxis, in PubMed, EMBASE, Web of Science and the Cochrane database of clinical trials from ... See full document

... observational meta-analyses [46], and tests for funnel plot asymmetry are not recommended for meta-analysis with less than 10 studies ...the patients with different liver ...of citrate ... See full document

... (AKIKI) trial demonstrated that mortality at 60 days was compar- able between the groups ...ELAIN randomized clinical trial revealed that the early initiation of RRT significantly reduced the 90-day ... See full document

... the trial, to receive heparin or citrate for CVVH in predilution mode in a single-blinded ...All randomized patients were ...change therapy were also considered exclusion ... See full document

... ELAIN trial has some ...published meta-analysis regarding the initiation of renal replacement therapy analyzed 15 trials published between 1985 and 2011 and the authors ... See full document

... Our trial design was unusual, as not all patients with suspected HIT could be expected to reach the primary ...recruited patients at the time point when HIT was suspected, need for renal ... See full document

... for continuous renal replacement therapy (CRRT) in the Intensive Care Unit (ICU) based on its effi- cacy and safety profile ...Several randomized controlled trials have ... See full document

... historically controlled trial and five studies of technical ...formal meta-analysis because there could be greater heterogeneity in a systematic review of non-randomized studies than ... See full document

... of citrate Th e use of citrate off ers many advantages to the patient, which can only be taken if the risks are well ...of citrate should start with the choice of a well-designed and fl exible protocol ... See full document

... 69 critically ill patients with liver ...Eight patients were treated with liver replacement therapy, and 30 underwent ...of citrate was detected indirectly by total serum ... See full document

... custom-made citrate solutions. In a recent multicenter randomized study, a custom-made calcium-free triso- dium citrate replacement fluid ...mmol citrate/L) was compared with ... See full document

... in critically ill patients ...in patients on ...of regional anticoagulation with ...of critically illness, as measured by SAPS ...because citrate metabolism takes ... See full document

... given via the gastrointestinal tract. A possible cause of this result is that those ICU patients with good intestinal function can maintain good nutrition without glutam- ine supplementation. Therefore, glutamine ... See full document

... 252 patients with dialysis-dependent ARF to a prospective single-center randomized controlled trial, we observed no statistically significant differences regarding 14-day-, 30-day-, all- cause ... See full document

... included trials as described above, downgrad- ing the quality of the ...SPLIT trials with more than 98% of patients could not be ignored despite no statistical difference accord- ing to sensitivity ... See full document

... Large randomized controlled trials comparing RRT to conservative management in selected ICU patients with AKI, and focusing on RRT timing, are urgently warranted to provide definite ... See full document

... our meta-analysis are the comprehen- sive and most up-to-date search of the worldwide litera- ture without restriction to only English-written articles, the inclusion of data from the largest and most ... See full document

... updated meta-analysis to evaluate the effect of EEN on critically ill ...for patients included in our study are more ...and patients, including trau- ma, transplantation ... See full document