[PDF] Top 20 A Reliable Phenotype Predictor for Human Immunodeficiency Virus Type 1 Subtype C Based on Envelope V3 Sequences
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A Reliable Phenotype Predictor for Human Immunodeficiency Virus Type 1 Subtype C Based on Envelope V3 Sequences
... HIV-1 subtype C V3 sequences was compiled from published literature, the Entrez nucleotide database ...for sequences, accession numbers, and references). Only sequences ... See full document
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Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model
... HIV-1 subtype C is estimated to comprise more than 50% of all infections in the pandemic (8, 18, 19, 50) and is the pre- dominant subtype in southern Africa and parts of Asia, where the HIV ... See full document
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Evolution of the human immunodeficiency virus type 1 subtype-specific V3 domain is confined to a sequence space with a fixed distance to the subtype consensus.
... J) based on phylogenetic analysis of the envelope sequences ir- respective of whether the complete gp120 or the V3 region is analyzed (31, ...gp120 V3 region, the intra- host evolution ... See full document
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Cross-Subtype Neutralizing Antibodies Induced in Baboons by a Subtype E gp120 Immunogen Based on an R5 Primary Human Immunodeficiency Virus Type 1 Envelope
... and virus inoculum (100 50 tissue culture infective doses) were preincubated for 30 min prior to addition of target ...media. Virus growth was monitored by ELISA measurement of p24 antigen in culture ... See full document
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Role of Naturally Occurring Basic Amino Acid Substitutions in the Human Immunodeficiency Virus Type 1 Subtype E Envelope V3 Loop on Viral Coreceptor Usage and Cell Tropism
... original sequences flanking the V3 loop region of the LAI env gene (Table 1; ...FIG. 1. Schematic representation of the construction of LAI-based infectious molecular clones with ... See full document
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Extensive Intrasubtype Recombination in South African Human Immunodeficiency Virus Type 1 Subtype C Infections
... the subtype C epidemic with the recombinants removed was earlier than that with all ...of envelope sequences, the MRCA of the HIV-1 epidemic in humans is thought to have taken place ... See full document
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Characterization of V3 Sequence Heterogeneity in Subtype C Human Immunodeficiency Virus Type 1 Isolates from Malawi: Underrepresentation of X4 Variants
... Is V3 really variable? The original description of five vari- able regions flanked by conserved regions in the env gene was based on sequence comparisons of subtype B viruses that in- cluded R5-like ... See full document
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In Vivo Emergence of Vicriviroc Resistance in a Human Immunodeficiency Virus Type 1 Subtype C-Infected Subject
... cloned envelope genes from weeks 16 and 19 demonstrated a progressive decrease in VCV suscep- ...Recombinant virus expressing the cloned week 28 env showed no inhibition by VCV; increasing VCV ... See full document
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Human Immunodeficiency Virus Type 1 Env Sequences from Calcutta in Eastern India: Identification of Features That Distinguish Subtype C Sequences in India from Other Subtype C Sequences
... Table 1. Most acquired HIV-1 infection through heterosex- ual contact and had exposure to multiple sex ...viral envelope gene was amplified by a nested PCR as previously described (15, 26), using ... See full document
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Evidence for Frequent Reinfection with Human Immunodeficiency Virus Type 1 of a Different Subtype
... The subtype of virus at the early time point was defined on the basis of envelope V1 to V3 sequences by using either the heteroduplex mobility assay or sequence analysis as described ... See full document
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Subtype-Specific Conformational Differences within the V3 Region of Subtype B and Subtype C Human Immunodeficiency Virus Type 1 Env Proteins
... The subtype B and C nucleotide sequences corresponding to the V3 region of gp120 (HXB2 nucleotides 7111 to 7217) were downloaded from the Los Alamos HIV Sequence Database ...the subtype ... See full document
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Variability in the Human Immunodeficiency Virus Type 1 gp120 Env Protein Linked to Phenotype-Associated Changes in the V3 Loop
... of human immunodeficiency virus type 1 (HIV-1) are classified according to the chemokine receptor (coreceptor) used in conjunction with CD4 to target and enter cells: viruses ... See full document
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Enhanced Infectivity of an R5-Tropic Simian/Human Immunodeficiency Virus Carrying Human Immunodeficiency Virus Type 1 Subtype C Envelope after Serial Passages in Pig-Tailed Macaques (Macaca nemestrina)
... Amplification of HIV-1 tat/rev/env using a nested PCR method. The specimens for this experiment were PBMC derived from individuals naturally infected with HIV-1 in Yunnan, China. These primary strains were ... See full document
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A Group of V3 Sequences from Human Immunodeficiency Virus Type 1 Subtype E Non-Syncytium-Inducing, CCR5-Using Variants Are Resistant to Positive Selection Pressure
... HIV-1 subtype E of Thai origin in- fected the father (NH1), who transmitted the virus to the mother (NH2), who then transmitted the virus to her child (NH3) (35, ...clonal sequences, we ... See full document
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Comparative Immunogenicity of Subtype A Human Immunodeficiency Virus Type 1 Envelope Exhibiting Differential Exposure of Conserved Neutralization Epitopes
... candidate envelope immunogens have had limited ability to cross-neutralize heterol- ogous ...of subtype A variants of HIV-1, rabbits were immunized with pairs of closely related subtype A ... See full document
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Mutational trends in V3 loop protein sequences observed in different genetic lineages of human immunodeficiency virus type 1.
... When phylogenetic subtype designations based on longer nucleotide sequences were superimposed on shorter V3 protein clustering patterns to identify common sequence elements in geneticall[r] ... See full document
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Evolution of Envelope Sequences of Human Immunodeficiency Virus Type 1 in Cellular Reservoirs in the Setting of Potent Antiviral Therapy
... viremia based on less sensitive assays (thresholds between 50 and 200 copies/ml), a subset will not have achieved complete suppres- sion of viral ...cation-competent virus (whether in latently or ... See full document
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Human immunodeficiency virus type 1 tropism for T-lymphoid cell lines: role of the V3 loop and C4 envelope determinants.
... line-tropic V3 domains, this study identifies the V3 loop and the C4 domain (residues K-429 and S-440) as two determinants of the envelope protein that functionally interact to mediate infectiv- ity ... See full document
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Quantifying Differences in the Tempo of Human Immunodeficiency Virus Type 1 Subtype Evolution
... each subtype for pol and ...and C (P ⫽ ...and C, we could collect such full-genome data sets since there is a reasonable number of publicly available ...and C full) with the other data sets ... See full document
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Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
... A recent study by Gao et al. (21) evaluated the use of a group M consensus envelope as an immunogen. An artificial gene, CON6, was derived from a consensus of multiple HIV-1 subtypes, instead of clade B, as ... See full document
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