[PDF] Top 20 Remote ischemic conditioning in septic shock (RECO Sepsis): study protocol for a randomized controlled trial

Remote ischemic conditioning in septic shock (RECO Sepsis): study protocol for a randomized controlled trial

... The trial will end once 180 patients have been enrolled and have completed the 90 days’ follow-up. No interim analysis will be planned for this study. A full statistical analysis plan will be drawn up by ... See full document

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Remote ischemic conditioning in ST elevation myocardial infarction as adjuvant to primary angioplasty (RIC STEMI): study protocol for a randomized controlled trial

... “ Remote ischemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty ” (RIC-STEMI) is an ongoing prospective, single-center, open-label, randomized ... See full document

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The EUPHRATES trial (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock): study protocol for a randomized controlled trial

... in sepsis. Studies measur- ing endotoxin levels in septic patients have consistently demonstrated three key ...in septic patients and adverse outcomes including organ failure and death [5]; second, ... See full document

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Remote ischemic preconditioning in the prevention of ischemic brain damage during intracranial aneurysm treatment (RIPAT): study protocol for a randomized controlled trial

... direct ischemic preconditioning; DWI: diffusion-weighted imaging; EEG: electroencephalography; FA: fractional anisotropy; FACS: fluorescence- activated cell sorting; FLAIR: fluid attenuation inversion recovery; ... See full document

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ADJunctive Ulinastatin in Sepsis Treatment in China (ADJUST study): study protocol for a randomized controlled trial

... The study group and the control group will receive ulinastatin (400,000 IU every 8 h) and placebo, re- spectively, for 10 days, with the first dose adminis- tered within 8 h of study ...the study ... See full document

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Landiolol in patients with septic shock resident in an intensive care unit (LANDI SEP): study protocol for a randomized controlled trial

... Beta-blockers are potential candidates to control HR and numerous animal models provide a rationale for their use during sepsis [17–24]. Despite concerns of hemodynamic decompensation, recent clinical studies ... See full document

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The effect of repeated remote ischemic postconditioning on infarct size in patients with an ischemic stroke (REPOST): study protocol for a randomized clinical trial

... 200 ischemic stroke patients to daily rIPostC or sham conditioning during hospitalization into a randomized single-blind placebo-controlled ... See full document

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Alkaline phosphatase for treatment of sepsis induced acute kidney injury: a prospective randomized double blind placebo controlled trial

... severe sepsis or septic shock, the remarkable consistency of findings in this trial (attenuation of urinary excretion of markers of renal damage and improved clinical outcomes), and in the ... See full document

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Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trial

... I, randomized trial by Fowler et ...severe sepsis and septic shock. In another small randomized trial by Zabet et ...double-blind trial in patients (n = 88) with ... See full document

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Echocardiogram-guided resuscitation versus early goal-directed therapy in the treatment of septic shock: a randomized, controlled, feasibility trial

... our trial, a median of 3 L or 35 mL/kg, was higher than other recent major trials of early sepsis ...EGDT study, enrollment depended on hypotension following a fluid bolus of 20–30 mL/kg of ... See full document

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Primary prevention for risk factors of ischemic stroke with Baduanjin exercise intervention in the community elder population: study protocol for a randomized controlled trial

... are randomized trials, most have significant methodological limitations, and we are not aware of any trials that have evaluated the impact of Baduanjin exercise on primary prevention of stroke in the community ... See full document

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Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis

... inhibitor study, in which statistically higher mortality was observed in the active treatment arm, reported a higher inci- dence of cardiovascular related deaths in the active treatment ...No study reported ... See full document

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IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial

... The sublingual microcirculation was evaluated by means of incident dark field (IDF) videomicroscopy (Cytocam, Braedius Medical, Amsterdam, The Nether- lands). The Cytocam-IDF is a third-generation handheld microscope ... See full document

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Bench to bedside review: The initial hemodynamic resuscitation of the septic patient according to Surviving Sepsis Campaign guidelines – does one size fit all?

... severe sepsis or septic shock [10] (Table ...of sepsis which recommend filling pressures of between 12 and 15 mm Hg for the optimization of cardiac output ...a study that was done in ... See full document

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Sepsis-3 definitions predict ICU mortality in a low–middle-income country

... new sepsis definitions raised several concerns [26, 27], and the Surviving Sepsis Campaign suggested that lactate should continue to be measured to identify dysfunction ...validation study of ... See full document

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Endovascular Approaches to Acute Stroke, Part 2: A Comprehensive Review of Studies and Trials

... tiation of IV rtPA. Approximately 26 patients will be enrolled at 4 sites worldwide. To date, 22 patients have been enrolled, and enrollment is expected to be completed by May 2009. Of the 13 patients in whom preliminary ... See full document

Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta analysis of mortality in the control arm, 2002–2016

... present study support their results of a declining mortality trend in the control arm of sepsis trials, although an important difference was found as they demonstrated that the declining sepsis ... See full document

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Recombinant human activated protein C for the treatment of severe sepsis and septic shock: a study protocol for incorporating observational evidence using a Bayesian approach

... with sepsis will be ...1. Trial sequential analysis will be performed to quantify the reliability of data in meta-analysis adjusting significance levels for sparse data and multiple testing ... See full document

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A randomized double blind controlled trial of the use of dydrogesterone in women with threatened miscarriage in the first trimester: study protocol for a randomized controlled trial

... Every attempt will be made to collect full follow-up data on all women (unless a woman withdraws consent for follow-up data collection). In particular, women will be followed up even after protocol violation. It ... See full document

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Remote ischemic preconditioning to reduce contrast induced nephropathy: study protocol for a randomized controlled trial

... CIN. Remote ischemic preconditioning (RIPC) is a short and harmless discontinuation of blood supply to particular organs or tissue, followed by reperfu- sion ...cohort study by Whittaker et ...a ... See full document

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