[PDF] Top 20 Repeat Transduction in the Mouse Lung by Using Adeno-Associated Virus Vectors with Different Serotypes
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Repeat Transduction in the Mouse Lung by Using Adeno-Associated Virus Vectors with Different Serotypes
... reduced transduction rates when animals were given a vector with the cross-reactive se- ...The mouse data also show that AAV6 is immunolog- ically distinct from AAV2 and AAV3 since exposure to these ... See full document
9
Successful Readministration of Adeno-Associated Virus Vectors to the Mouse Lung Requires Transient Immunosuppression during the Initial Exposure
... following adeno-associated virus (AAV) vector administration to the rabbit ...tested repeat vector administration, but no additional transduction was observed, and the block to ... See full document
11
Comparative analysis of the transduction efficiency of five adeno associated virus serotypes and VSV G pseudotype lentiviral vector in lung cancer cells
... apies. Adeno-associated virus and lentivirus have been widely studied and used for gene ...high transduction efficiency of the chosen viral delivery vector plays an important role in the ... See full document
10
Adeno-Associated Virus Type 6 (AAV6) Vectors Mediate Efficient Transduction of Airway Epithelial Cells in Mouse Lungs Compared to That of AAV2 Vectors
... Although vectors derived from adeno-associated virus type 2 (AAV2) promote gene transfer and expression in many somatic tissues, studies with animal models and cultured cells show that the ... See full document
10
Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors
... retinal transduction by AAV ...AAV serotypes known to interact with HS onto those that do not. Using structural information, we next created a series of AAV2- based mutants with altered heparin ... See full document
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Capsid Antibodies to Different Adeno-Associated Virus Serotypes Bind Common Regions
... The adeno-associated viruses (AAVs) being developed as vectors for corrective human gene delivery have shown promise in clinical trials, but preexisting antibodies are detrimental to successful ... See full document
14
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.
... with transduction by the AAV ...acute lung inflammation seen after administration of adenovirus vectors, were not observed after delivery of AAV vector ...vector transduction or transgene ... See full document
10
Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer
... by using rep from AAV2 and cap from AAV5 together with a plasmid containing a vector based on AAV2; this was also purified by cesium chloride ...of vectors based on AAV2 versus AAV2/5, we utilized common ... See full document
5
Infectious Clones and Vectors Derived from Adeno-Associated Virus (AAV) Serotypes Other Than AAV Type 2
... AAV serotypes could prove espe- cially useful for transducing cells that are resistant to AAV2 ...a different recep- tor (37). Thus, vectors based on other AAV serotypes may have a host range ... See full document
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Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors
... photoreceptor transduction with novel AAV serotypes and ...AAV serotypes and promoters, we generated an expres- sion cassette containing the coding sequence for the EGFP with an NLS (designated ... See full document
9
Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9
... with different promoters and reporters could clarify this potential ...AAV transduction between myofiber types ...AAV transduction and cell type speci- ficity is still poorly ...at different ... See full document
10
Unrestricted Hepatocyte Transduction with Adeno-Associated Virus Serotype 8 Vectors in Mice
... these mouse models, phosphorylated forms of FKBP52, known to bind to the AAV inverted terminal repeat and block second-strand synthesis (43), are downregulated or ...liver transduction with rAAV2 ... See full document
11
Adeno-associated Virus Vectors Efficiently Transduce Mouse and Rabbit Sensory Neurons Coinfected with Herpes Simplex Virus 1 following Peripheral Inoculation
... greater transduction efficiency, as the capsid serotype is a major determinant of cell tropism ...New serotypes are constantly being discovered or engineered and tested for effi- cacy in cell culture and ... See full document
8
Single Amino Acid Changes Can Influence Titer, Heparin Binding, and Tissue Tropism in Different Adeno-Associated Virus Serotypes
... higher transduction of hepatocytes by AAV6 than by ...achieved using AAV1 and AAV6 compared with mutants AAV1-E531K and AAV6- K531E in HepG2 cells (n ⫽ ...(sc) vectors (5 ⫻ 10 10 /mouse) ... See full document
5
Nonrandom Transduction of Recombinant Adeno-Associated Virus Vectors in Mouse Hepatocytes In Vivo: Cell Cycling Does Not Influence Hepatocyte Transduction
... Recombinant adeno-associated virus vectors (rAAV) show promise in preclinical trials for the treatment of genetic diseases including ...stable transduction in vivo was ...Two ... See full document
11
Lack of Repeat Transduction by Recombinant Adeno-Associated Virus Type 5/5 Vectors in the Mouse Airway
... T-lymphocyte- associated antigen 4-human IgG Fc (CTLA4Ig) coding region from pCDM8- CTLA4Ig (American Type Culture Collection clone ...prepared using QIAGEN Endofree Megaprep kits (QIAGEN, Crawley, United ... See full document
8
Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity
... Our initial analysis of AAV3, -4, and -5 hybrid helper con- structs resulted in reduced ability to generate high-titer vec- tors. Recent studies have demonstrated that the first 232 amino acids of AAV2 rep is required ... See full document
11
Gene Therapy Vectors Based on Adeno-Associated Virus Type 1
... AAV-2 vectors in some applications. Furthermore, AAV-1 and AAV-2 vectors should not cross-neutralize, providing impor- tant advantages when used in the context of preexisting immu- nity due to a natural ... See full document
10
Mechanistic Insights into the Enhancement of Adeno-Associated Virus Transduction by Proteasome Inhibitors
... enhance transduction in many cell types both in vitro and in ...very different cellular roles from the proteasome, which degrades ubiquitinated cytoplasmic and nuclear proteins, including lysosomal ... See full document
7
CpG depleted adeno associated virus vectors evade immune detection
... AAV vectors by TLR9 include pharmacological administration of oli- gonucleotide inhibitors at the time of vector transduction ...AAV vectors overcome the limitations ... See full document
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