[PDF] Top 20 DDX6 (Rck/p54) Is Required for Efficient Hepatitis C Virus Replication but Not for Internal Ribosome Entry Site-Directed Translation
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DDX6 (Rck/p54) Is Required for Efficient Hepatitis C Virus Replication but Not for Internal Ribosome Entry Site-Directed Translation
... in virus yields com- pared to cells transfected with a control EYFP vector ...that DDX6 expression levels correlate with the efficiency of HCV replication, the small increases in virus yield ... See full document
15
Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation
... various virus infections, including hepatitis B virus (HBV), hepatitis C virus (HCV), HIV, Epstein-Barr virus (EBV), and Sendai virus infections ...other ... See full document
17
The Picornavirus Avian Encephalomyelitis Virus Possesses a Hepatitis C Virus-Like Internal Ribosome Entry Site Element
... from hepatitis A virus (HAV) represents a third type of ...binding site (reviewed in reference ...be required by group I and II IRES elements since dominant- negative mutants of this protein ... See full document
11
Cell Type-Specific Enhancement of Hepatitis C Virus Internal Ribosome Entry Site-Directed Translation due to 5′ Nontranslated Region Substitutions Selected during Passage of Virus in Lymphoblastoid Cells
... the replication of the H77 ...the translation studies described in this communication were not evaluated directly for their ability to support HCV ... See full document
8
Attenuation of Rabies Virus Replication and Virulence by Picornavirus Internal Ribosome Entry Site Elements
... IRES translation activity, accumulation of P pro- tein, RV replication, and the capability of recombinant RV to prevent IFN-mediated antiviral host ...pression, replication, and pathogenicity of NNS ... See full document
9
Differential Effects on the Hepatitis C Virus (HCV) Internal Ribosome Entry Site by Vitamin B12 and the HCV Core Protein
... inhibit translation from the HCV ...encephalomyocarditis virus IRES-directed transla- tion in HepG2 cells ...of translation by the HCV core protein, a recombinant vaccinia virus (RecVV- ... See full document
7
Hepatitis C Virus Internal Ribosome Entry Site (IRES) Stem Loop IIId Contains a Phylogenetically Conserved GGG Triplet Essential for Translation and IRES Folding
... the internal asymmetric loop whereas BVDV and CSFV actually contain two IIId loops (IIId and IIId⬘) with IIId containing a symmetric bulge be- tween helical ...for translation initiation factors compared to ... See full document
8
A Small Yeast RNA Blocks Hepatitis C Virus Internal Ribosome Entry Site (HCV IRES)-Mediated Translation and Inhibits Replication of a Chimeric Poliovirus under Translational Control of the HCV IRES Element
... Hepatitis C virus (HCV) is the primary causative agent of parenterally transmitted non-A, non-B hepatitis and affects a significant part of the worldwide ...chronic hepatitis, cirrhosis ... See full document
11
The DNA Virus White Spot Syndrome Virus Uses an Internal Ribosome Entry Site for Translation of the Highly Expressed Nonstructural Protein ICP35
... directly. Hepatitis B virus (HBV) X protein (HBx), for example, can interact with various transcription factors (including ATF-2, AP-2, CREB, HNF1, nu- clear factor-B ([NF-B], and DDB1) and modify their ... See full document
16
Unr Is Required In Vivo for Efficient Initiation of Translation from the Internal Ribosome Entry Sites of both Rhinovirus and Poliovirus
... for efficient translation initiation in reticulocyte lysates, picornaviral IRES elements have been assigned to three groups: the type I IRES elements of the enterovirus and rhinovirus group, the type II ... See full document
7
EWSR1 Binds the Hepatitis C Virus cis-Acting Replication Element and Is Required for Efficient Viral Replication
... epatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis, and hepatocellular ...RNA virus classified within the family Fla- ...An internal ribosome entry ... See full document
10
Cytoplasmic Expression of mRNAs Containing the Internal Ribosome Entry Site and 3′ Noncoding Region of Hepatitis C Virus: Effects of the 3′ Leader on mRNA Translation and mRNA Stability
... mediate efficient translation in rabbit reticulocyte lysate (6, ...in hepatitis A virus requires liver-specific extracts for efficient function in cell-free lysates ...Vaccinia ... See full document
6
Hepatitis C Virus Internal Ribosome Entry Site-Dependent Translation in Saccharomyces cerevisiae Is Independent of Polypyrimidine Tract-Binding Protein, Poly(rC)-Binding Protein 2, and La Protein
... of translation of some viral and cellular mRNAs is 5 ⬘ -end independent and occurs by internal binding of the 40S ribosomal subunit to an internal ribosome entry site (IRES) ... See full document
12
Mutational Analysis of the GB Virus B Internal Ribosome Entry Site
... GB virus B (GBV-B) is a recently discovered hepatotropic flavivirus that is distantly related to hepatitis C virus ...that translation of its polyprotein is initiated by internal ... See full document
11
Core Protein-Coding Sequence, but Not Core Protein, Modulates the Efficiency of Cap-Independent Translation Directed by the Internal Ribosome Entry Site of Hepatitis C Virus
... of translation on HCV ...IRES-directed translation when we expressed the full-length core protein from the recombinant baculovirus AcCACore in HepG2 cells ...cap-dependent translation, and it ... See full document
12
A Phylogenetically Conserved Stem-Loop Structure at the 5′ Border of the Internal Ribosome Entry Site of Hepatitis C Virus Is Required for Cap-Independent Viral Translation
... and internal bulge loops (highlighted in ...gated translation directed by the HCV IRES, in vitro and in vivo ...the internal helix is important for ...the internal helix of stem-loop ... See full document
10
The sequence element of the internal ribosome entry site and a 25-kilodalton cellular protein contribute to efficient internal initiation of translation of hepatitis C virus RNA.
... factors required for translation initiation of HCV RNA, we first incubated HeLa S10 lysate with excess amounts of the RNA transcripts of pUC5END-nc, -Snc, -Lnc, and -SLnc that contained wild-type or mutant, ... See full document
5
RNA-Binding Protein hnRNP D Modulates Internal Ribosome Entry Site-Dependent Translation of Hepatitis C Virus RNA
... NS5B, required for replication of HCV RNA) under the con- trol of the EMCV IRES ...is required for HCV IRES-dependent translation in HCV replicon-containing ...IRES-dependent ... See full document
12
The Hepatitis C Virus RNA 3′-Untranslated Region Strongly Enhances Translation Directed by the Internal Ribosome Entry Site
... on translation enhancement by the 3 ⴕ ...of translation by the HCV 3 ⬘ -UTR was detected ...dependent translation, Huh-7 cells were transfected with cir- cular plasmid DNAs of two types of the ... See full document
10
Translation initiation in GB viruses A and C: evidence for internal ribosome entry and implications for genome organization.
... GBV-C translation is initiated by internal ribosomal entry, only minimal translation of the down- stream cistron was noted from bicistronic transcripts contain- ing the 5 9 NTRs of ... See full document
10
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