[PDF] Top 20 REVIEW ARTICLE Fabry’s Disease — A comprehensive review on pathogenesis, diagnosis and treatment

... neutral glycosphingolipids with terminal a-galactosyl residue (ceramide di and tri hexoside) in lysosomes of endothelial, epithelial, smooth muscle cells, myocardial cells, nephrons, reticuloendothelial cells, connective ... See full document

... storage disease caused by mutations in the CYP27A1 gene; this gene codes for the mitochondrial enzyme sterol 27-hydroxylase, which is involved in bile acid ...of diagnosis and a diagnostic delay of 16 ... See full document

... and pathogenesis of the condition are not fully ...the disease, as well as towards providing optimal optical and surgical correction for improving the quality of vision in affected ...This ... See full document

... The pathogenesis is largely unknown. The aim of this review is to describe the spectrum of clinical conditions in which FCH occurs, common histopathologic findings, features unique to certain underlying ... See full document

... arthroscopic treatment has the advantages of small incisions, a beautiful appearance, little pain, and a short postoperative recovery peri- ...invasive treatment concepts and the continu- ous maturity of ... See full document

... Alzheimer’s disease (AD) is one of the most common cause of dementia in older adults and an important public health ...this review article is to provide a brief introduction to A D and the related ... See full document

... immunomodulatory treatment were ...immunodulatory treatment. In the current review, recent research in the areas of diagnosis, pathogenesis, and treatment of MMN and needs for ... See full document

... complex disease is thought triggered by interaction between genetics and environment, especially the shared epitope (SE) and cell surface calreticulin (CSC) ...the pathogenesis of rheumatoid arthritis, ... See full document

... nal spread is low; protective irradiation cannot prevent spinal metastasis [43, 44]. Teo [26] found that local recurrence in the original place is a major cause of implantation metastasis, as usually metastasis spreads ... See full document

... Fabry disease (FD) is an X-linked, hereditary, lysosomal storage disease caused by deficiency of enzyme α- galactosidase A (α-Gal A), which results in accumulation of neutral glycosphingolipid ... See full document

... Early diagnosis and timely treatment are of paramount importance in the prognosis of this condition but could be however challenging as it is infrequently observed in current daily ...this article ... See full document

... Despite the lack of a recognized predisposing ge- netic condition in most cases of malignancy, cancer must still be considered a genetic disease. That is, somatically acquired genetic changes play a major role in ... See full document

... This review presents the pathogenesis, diagnosis and the emerging nanoparticulate systems used in the treatment of chronic liver diseases caused by liver ...the treatment of hepatic ... See full document

... Pharmacokinetics (PK) is defined as the study of the kinetics of drug absorption, distribution, metabolism and elimination. Pharmacodynamics (PD) is defined as the time course for the drug effect and the relationship ... See full document

... In addition, cases exhibit similarities and differences. Time is important, especially for newborns. We believe that surgery is an effective treatment for gastric duplication. Clinical, laboratory and radiographic ... See full document

... Because patients suffering from TN often have vascular diseases such as atherosclerosis, arterial hypertonia, some authors suggested vascular theory of TN aetiology. They found morphological and functional disturbance in ... See full document

... advanced disease. Unlike other malignancies, oral cancer treatment has not drastically changed over the last 30 ...the treatment modality most commonly offered, with addition of radiation and ... See full document

... light on this problem by employing genomics, proteomics, and transcriptomics to detect markers correlated with HCC progression. Ju et al found that a type II Golgi-specific mem- brane protein, Golgi phosphoprotein 2, was ... See full document

... Neuropathological changes during the development of PD, itself, may lead to mild cognitive dysfunctions. As the disease progresses, cognitive impairments due to dementia are more consistent with AD. 16 Recent ... See full document

... sublingual route 3 . Oral cavity has been investigated for number of applications including the treatment of periodontal disease bacterial and fungal infection, aphthous and dental stomatitis. Over the last ... See full document