[PDF] Top 20 The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
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The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
... the T cells an individual will carry for their lifetime are formed but diminishes in size and activity with the onset of puberty (Gui et ...with T cell ‘education’ in the ...murine T cells ... See full document
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Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy
... direct cell-au- tonomous roles in T cells ...human T cells, which express only Arg2 ...mouse T cells ...a cell-autonomous role of Arg2. The mitochondrial localization of ... See full document
22
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3
... all T cells was reported ...conventional T cell development in their CD4-Cre Hdac3 condi- tionally deleted mice, though the mice failed to generate invariant NKT (iNKT) ...other cell types ... See full document
14
Function of metal ion homeostasis in the cell division cycle, mitochondrial protein processing, sensitivity to mycobacterial infection and brain function
... Mammalian cells accumulate iron by binding transferrin to its high-affinity receptor or through a transferrin-independent pathway (Jordan and Kaplan, 1994). A defect in the transferrin pathway results in iron deficiency, ... See full document
10
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
... Figure 9C and 9D compares the relative percentage apoptosis occurring in all splenocytes isolated from 3 week old wild-type mice and 3 week old UCP3 knock-out mice after 5 hour treatment with 1µM ... See full document
36
POS5 Gene of Saccharomyces cerevisiae Encodes a Mitochondrial NADH Kinase Required for Stability of Mitochondrial DNA
... central role in the cellular response to oxidative ...a mitochondrial function for the POS5 gene product was expected, and our identification of the Pos5 protein as a mitochondrial NADH ... See full document
12
Mitochondrial uncoupling protein 1 expression in thymocytes
... to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out ...1 protein ... See full document
5
Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase
... (1) mitochondrial oxidative phosphorylation, the major site of ATP produc- tion, and (2) AMP-activated protein kinase (AMPK), the master regulator of cellular energy ...by mitochondrial ... See full document
18
A role for taurine in mitochondrial function
... tant role in mitochondria in animal cells ...the cell membrane, a Na+- taurine symporter maintains a taurine gradient, whereas an osmo-sensitive channel regulates efflux of taurine (for reviews on taurine ... See full document
8
Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
... UCP-5 protein concentrations (treated vs mock) as a function of time (2 hours, 4 hours, 6 hours, and 24 hours) demonstrated a significant effect of time [F(3, 16) = ... See full document
6
<p>Characterization of the Golgi scaffold protein PAQR3, and its role in tumor suppression and metabolic pathway compartmentalization</p>
... cant cell proliferation networks, including Ras proto-oncogene (Ras)/mitogen- activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), insulin, and ... See full document
10
Structure and function of mitochondrial membrane protein complexes
... and cell division), the biosynthesis, folding and degradation of proteins, and the generation and maintenance of mem- brane ...the mitochondrial ATP syn- thase from ADP and phosphate ... See full document
11
TbDSS-1, an Essential Trypanosoma brucei Exoribonuclease Homolog That Has Pleiotropic Effects on Mitochondrial RNA Metabolism
... yeast mitochondrial degradosome (originally termed mtEXO) was first purified from Saccharomyces cerevisiae mi- tochondria a decade ago (39) and has been shown to play a role in multiple aspects of ... See full document
11
Uncoupling of cell respiration and oxidative phosphorylation: it’s possible role in obesity
... defective uncoupling capabilities and others would have enhanced uncoupling ...of mitochondrial inner membrane lipids may in part be a factor that contributes to the effectiveness of ... See full document
6
Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo
... (2, 3), has contributed to the idea that UCP3 is a candidate protein involved in the devel- opment of ...physiological role of UCP3 as a mitochondrial uncoupler, and thus its relation to ... See full document
9
Insights into brown adipose tissue evolution and function from non model organisms
... thermogenic role of BAT was clarified in the past century using integrative physiology and biochemistry (reviewed by Smith and Horwitz, ...broader role in the regulation of thermogenesis and energy ... See full document
9
The role of uncoupling protein 3 in human physiology
... an uncoupling effect of UCP3 or that an uncoupling effect was too weak to discern using this methodology, despite evidence marshaled by the authors that phos- phocreatine repletion rate is sensitive to ... See full document
5
Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T Cell profile and Peripheral T Cell Number
... spleen cell profiles, numbers and apoptotic potential may not in fact due to absence of UCP 1 directly, but due to secondary effects on BAT function in ...a role in the development of immune ... See full document
38
Subspecies differences in thermal acclimation of mitochondrial function and the role of uncoupling proteins in killifish
... fatty-acid-induced uncoupling using classic UCP inhibitors such as GDP or ...UCP function (Bouillaud et ...fatty-acid-induced uncoupling is not due to UCPs at all and is a result of another effect ... See full document
15
An investigation into the physiological expression and function of mitochondrial uncoupling protein 1 in thymus
... In our endeavours to understand the role of mitochondrial uncoupling protein 1 in thymocyte function, we compared cell profiles in thymus and spleen of wild-type mice with those of UCP 1[r] ... See full document
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