[PDF] Top 20 The role of Rac GTPases in B cell development and activation
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The role of Rac GTPases in B cell development and activation
... the development of this compartment (Martin and Kearney, 2000). A role for the BCR is also supported by observations of an absence or reduction in the MZ compartment in a number of mouse mutants with ... See full document
241
Targeting of Rac GTPases blocks the spread of intact human breast cancer
... by Rac via an autocrine or paracrine signal [33, ...of Rac inhibition preceding changes in STAT3 activity ex vivo. The role of STAT3 downstream of Rac activation was confirmed using ... See full document
12
Pak and Rac GTPases promote oncogenic KIT–induced neoplasms
... the role of Rac in MPNs, we also used pharmacologic approaches to test the pos- sibility of targeting Rac GTPases for the treatment of KITD814V- induced MPNs and ...established Rac ... See full document
16
The Role of Morphogens in B Cell Development
... of B cells with rShh was found to regulate peripheral B cell differentiation at different time points ...peripheral B cell subsets in the spleen of Dhh-/- mice compared to the Dhh+/+ ... See full document
206
Biochemical characterisation of rho/rac GTPases and their GTPase activating proteins in humans and Dictyostelium discoideum
... a role for rhoA in the aggregation o f lymphocytes by the leukocyte integrin LFA-1 which is inhibited by C3 transferase (Lang et ...similar role in the thrombin- and PMA-induced aggregation o f platelets ... See full document
240
Characterization of B Cell Development and Activation in the Absence of Akt or Presenilin
... MZ B cell development is the γ-secretase substrate Notch (Tanigaki, Han et ...follicular B cells support a role for the activation of Akt downstream of the Notch pathway (Ciofani ... See full document
133
The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus
... central role in the development of B ...of B cell lineage specification and commit- ment and is expressed throughout B cell development up to the plasma cell ... See full document
13
Genetic Structure and Evolution of RAC-GTPases in Arabidopsis thaliana
... of GTPases, Rho, Rac, and Cdc42, tip growth through targeted secretions of vesicles (Kost is a diverse group of proteins with an evolutionary et ...of Rac history dating back to the first unicellular ... See full document
14
Analysis of the role of the Rac/Cdc42 GTPases during planar cell polarity generation in Drosophila
... family GTPases are involved in PCP ...The role of Rac in PCP establishment was also addressed using dominant-negative and activated isoforms of Rac1, which produce PCP phenotypes in the eye (Fanto et ... See full document
10
Induction of the Gαq Signaling Cascade by the Human Immunodeficiency Virus Envelope Is Required for Virus Entry
... Env-dependent cell-cell fusion and Rac-1 ...to activation of the ryodine receptor (RyR)- operated Ca 2⫹ channel, leading to a further increase in intra- cellular Ca 2⫹ ...the role for ... See full document
15
Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1
... The cell bodies of external cuneatus neurons (ECN) and of lateral reticular neurons (LRN) cross the midline and continue their translocation until reaching their presumptive territories in the contralateral ... See full document
12
Regulation of cell-cell adhesion in keratinocytes: The reciprocal relationship between cadherins and Rho family GTPases
... during development where changes in cadherin-mediated adhesion occur without changes in cadherin ...triggers activation o f adhesion through recruitment o f E-cadherin at the cell surface to ... See full document
185
Rac and Rho GTPases in cancer cell motility control
... of Rac/Rho balance in favor of the last induce MAT as ...of Rac to cell protrusions [93] and the inhibition of E3 ubiquitin ligase Smurf1, which leads to Rho degra- dation directly at the leading ... See full document
14
Novel role of Rac Mid1 signaling in medial cerebellar development
... small GTPases and plays important roles in neuritogenesis, including axonogenesis and dendritogenesis, neuronal migration and modulation of gene transcription (Bosco et ...involve Rac signaling, the number ... See full document
13
Identification of new targets for the Rho and Rac GTPases
... a b e, 1997 ). p l 4 0 m D i a binds to Rho, but not Rac or Cdc42, in a G TP-dependent manner and is a 140 kDa mem ber of a family of form in-related proteins, which includes D r o s o p h i l a D iaphanous ... See full document
188
Activation of human B cells negatively regulates TGF-β1 production
... signals B cells re- ceive, proinflammatory or immunoregulatory cytokines can be produced, and the shift towards an inflammatory or a protective/suppressive immune response will occur ...blood B cells to ... See full document
12
The role of Otx and Otp genes in brain development
... gland. Cell culture experiments indicate that Otx1 may activate transcription of the growth hormone (GH), follicle-stimulating hormone ( β FSH), luteinizing hormone ( β LH), and α -glycoprotein subunit ( α GSU) ... See full document
9
Interleukin-9 Is Associated with Elevated Anti-Double-Stranded DNA Antibodies in Lupus-Prone Mice
... Th9 cells in MRL/lpr mice remains un- known. We first identified CD4 + IL-9 + Th9 cells in MRL/lpr mouse spleens (Figure 1A). The percentage of CD4 + IL-9 + Th9 cells was expanded in spleens of MRL/lpr mice (1. 34 ± 0. ... See full document
7
Cell cell signaling and adhesion in phagocytosis and early development of Dictyostelium
... of development, because of a unique combination of cell biological, biochemical and molecular genetic approaches that can be used in this ...or cell behavior within the multicellular organism can be ... See full document
10
The cell biology of autophagy in metazoans: a developing story
... exclusive role for autophagy in mouse neuronal development has been reported for the Ambra1 (activating molecule in beclin 1- regulated autophagy) protein (Fimia et ...programmed cell death, an ... See full document
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