[PDF] Top 20 Role of splice variants in the metastatic progression of prostate cancer
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Role of splice variants in the metastatic progression of prostate cancer
... localized prostate cancer largely results in excellent survival ...contrast, metastatic prostate cancer is associated with a decreased survival rate of 33% ...mesenchymal-like ... See full document
5
Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer
... of prostate cancer patients in Western countries [3, 4, 17, 29, ...from prostate cancer patients by several investigators has shown the presence of multiple forms containing varying lengths of ... See full document
12
Pharmacodynamic and Clinical Results from a Phase I/II Study of the HSP90 Inhibitor Onalespib in Combination with Abiraterone Acetate in Prostate Cancer.
... whereby cancer cells can be rendered less susceptible to the effects of HSP90 ...a role in resistance to HSP90 inhibition, rescuing client proteins including AR and its splice variants from ... See full document
26
Circulating tumour cell increase as a biomarker of disease progression in metastatic castration-resistant prostate cancer patients with low baseline CTC counts.
... The role of increasing CTC counts as an indicator of disease progression has been less well ...the role of increasing CTCs as a biomarker of progression analysing exclusively patients with low ... See full document
7
Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression
... and prostate cancer pro- gression was replicated across two independent and different types of cohorts, which largely reduces the chance of false-positive ...the role of NPAS2 rs6542993 in patient ... See full document
9
Uncovering the role of p53 splice variants in human malignancy: a clinical perspective
... and cancer progression remains ...the cancer research ...important role in regulating cell fate in response to different stresses in normal cells by differentially regulating gene ...In ... See full document
12
An imaging agent to detect androgen receptor and its active splice variants in prostate cancer
... active splice variants of androgen receptor (AR-Vs) lacking ligand-binding domain (LBD) are a mechanism of resistance to androgen receptor LBD–targeted (AR LBD–targeted) therapies for metastatic ... See full document
16
Diabetes and beta adrenergic blockage are risk factors for metastatic prostate cancer
... advanced prostate cancer [25] and beta-blockers have been associated reduced mortality in various tumor types ...The prostate, especially the peripheral zone where most of the tumors originate, shows ... See full document
6
TRAF4 mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis
... important role in driving cancer ...drive prostate cancer remain incompletely ...RTK-mediated prostate cancer ...in metastatic prostate ...RTK-mediated ... See full document
16
Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells
... of cancer metastasis and screen novel therapeutics are an urgent unmet medical ...need. Prostate cancer frequently metastasizes to bone and soft tissues including brain ...on prostate ... See full document
13
Androgen receptors beyond prostate cancer: an old marker as a new target
... the progression of prostate cancer led to the development of abiraterone acetate, an oral specific inhibitor of CYP17A1, which is a rate-limiting enzyme in androgen (and estrogen) synthesis that, ... See full document
12
Management algorithms for prostate specific antigen progression in prostate cancer: Biochemical recurrence after definitive therapy and progression to non metastatic castrate resistant prostate cancer
... involves multiple clinical specialties, many treatment options, and may involve travel to multiple centres. This may be daunting for some patients, placing them at higher risk for experiencing disparities in care. 46 ... See full document
15
Metastatic Prostate Cancer
... with prostate cancer is a major global health care challenge, compounded by an aging population and increasing frequency of ...of metastatic disease, which continues to be associated with a high rate ... See full document
13
Biomarker microRNAs for prostate cancer metastasis: screened with a network vulnerability analysis model
... In our previous studies, we proposed a network-based bioinformatics model called Pipeline of Outlier Micro- RNA Analysis (POMA) to detect microRNA biomarkers for cancer diagnosis and prognosis [20–22]. The model ... See full document
16
<p>Impact of tumor cytoreduction in metastatic prostate cancer</p>
... of metastatic hormone- sensitive prostate ...the Prostate (group ...the progression-free survival ...patient progression (median PFS 20 months (group 1) vs 43 months (group ... See full document
6
iTRAQ Identification of Candidate Serum Biomarkers Associated with Metastatic Progression of Human Prostate Cancer
... bone metastatic prostate cancer, and have been associated with an adverse outcome for men with castration resistant prostate cancer ...in metastatic cases is consistent with ... See full document
10
Cost effectiveness of docetaxel in high volume hormone sensitive metastatic prostate cancer
... An economic model was constructed to conduct a cost-effectiveness analysis and a cost-utility analysis following the guidelines outlined by CADTH. 18 A partitioned survival model was developed for high-volume ... See full document
16
Prognostic Impacts of Metastatic Site and Pain on Progression to Castrate Resistance and Mortality in Patients with Metastatic Prostate Cancer
... CRPC progression, and the site of ...as progression of disease or elevation of serum PSA using the Prostate Cancer Working Group 2 (PCWG2) cri- teria, 11 with progression to CRPC-free ... See full document
7
Management algorithms for metastatic prostate cancer
... PSA Progression as defined by PCWG2 ...diagnosed metastatic castration-resistant prostate ...for metastatic castration-sensitive prostate cancer; 4 PSA progression as ... See full document
24
Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression
... the prostate and in the development and/or progression of prostate cancer, we investigated the effects of extracellu- lar zinc on zinc accumulation and on mRNA and protein expression of zinc ... See full document
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