[PDF] Top 20 Roles of Long non coding RNAs in Cellular Stress Response

... The cellular system is constantly subjected to stress in response to a variety of conditions such as a transient exposure to hot or cold temperatures, heavy metals, exogenous chemicals, oxidative ... See full document

... Long non-coding RNAs (lncRNAs) belong to a group of RNAs that are longer than 200 nucleotides and are not translated into ...various cellular processes, including chromatin ... See full document

... discovery, non-coding RNAs have been known as key regulators of gene ...targets. Long non-coding RNAs (lncRNAs) are a group of RNAs composed of >200 nucleotides ... See full document

... of long-noncoding RNAs (lncRNAs), which are capable of interactions with DNA, RNA and protein molecules, thereby enabling a variety of transcriptional and post-transcriptional regulatory ... See full document

... Breast cancer has long been a serious threat to the health of women around the world [56]. With in-depth studies on the occurrence and development of breast cancer, re- searchers have found that breast CSCs appear ... See full document

... the roles and molecular characteristics of these lncRNAs remain largely unexplored. The expression pattern and role of one lncRNA may be significantly different in dif- ferent metabolic processes due to the ... See full document

... the roles of lncRNAs in cisplatin chemoresistance (Table 1) through mechanisms such as alterations in cellular uptake or efflux of the drug, intracellular detoxification, cell apoptosis, autophagy, DNA ... See full document

... Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleo- tides mostly transcribed by RNA which do not encode ...their roles in carcinogenesis such as MALAT1 is responsible ... See full document

... on cellular proliferation and colony-forming ability of tumor cell lines in a miR-15a/16-1-dependent manner ...unexplained, roles for DLEU2 in CLL development might be ... See full document

... their roles in the regulation of gene expression remain incompletely understood and the phenotypic characterisation of many vertebrate lncRNAs has been challenging and has provided sometimes contradictory results ... See full document

... LncRNAs play critical roles in epigenetic modulation of chromatin structure by regulating key genes in spe- cific cancerous cells [186,187]. Distinct chromatin signa- tures are associated with lncRNAs encoding ... See full document

... immune response in human monocytes and monocytic cell lines have been extensively studied using both microarrays 1 and serial analysis of gene expression 2,3 ...in response to Toll-like receptor 4 (TLR4) ... See full document

... Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression during development (Pauli et ...essential roles in imprinting (Barlow et ...developmental ... See full document

... intergenic non-coding RNAs (lincRNAs) ...functional roles of lncRNAs is limited and based on the studies of a very few ...these RNAs par- ticipate ...regulatory roles of many of ... See full document

... protein-coding RNAs and ncRNAs. Traditionally, a number of genome’ s repertoire of non-protein-coding transcripts may be viewed as in- consequential transcriptional “noise” or ...functional ... See full document

... PRRT3-AS1) through a combination of WGCNA, univariate Cox regression analysis, and LASSO PH model. Moreover, a six-lncRNA-based risk scoring system was constructed and capable to classify GBM patients into two risk ... See full document

... the non-coding transcripts actually provide a complex multi-layered regulatory network essential for the self-organized ...“non-coding” RNAs (ncRNAs) have also ...known long ... See full document

... All the information previously described along with several other findings have strongly confirmed how some lncRNAs profiles can predict either sensitivity and/or resistance capacity to cisplatinum-based and/ or ... See full document

... immune response, and stress reactions. A large por - tion of these RNAs are denoted as long non-coding RNAs (lncRNAs) which function as signaling mol- ecules, navigating ... See full document

... in response to angiotensin II ...interfering RNAs (siRNA) have been shown to have an opposite effect by silencing the expression of the DOT1 gene ...contractile response in smooth muscle cells ... See full document