[PDF] Top 20 Selection for Human Immunodeficiency Virus Type 1 Recombinants in a Patient with Rapid Progression to AIDS
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Selection for Human Immunodeficiency Virus Type 1 Recombinants in a Patient with Rapid Progression to AIDS
... major recombinants (V3r, C2V3r, and X4r) plus eight minor HIV-1 Env C2-V5 recombinants (MI-1 to ...C2V3r recombinants; and eight minor recombinants (MI-1 to ...white ... See full document
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Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to disease.
... between rapid- and slow-progressor in- fants is that the latter are able to curtail and modulate viral replication after the first phase of replication soon after birth (16), thus confirming the evidence that high ... See full document
13
Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses.
... of progression to AIDS in human immunodeficiency virus type 1 (HIV-1)-infected individuals is determined by a complex series of interactions between the host and ... See full document
12
Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1
... including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus of macaque monkeys ...a patient nef allele, and a nef consensus ... See full document
12
Changes in Human Immunodeficiency Virus Type 1 Fitness and Genetic Diversity during Disease Progression
... 3a; patient M, Fig. 3b). For patient U, the decrease in ex vivo fitness and stabilization of genetic diversity and divergence was observed after 2 years of ARV ...counts. Patient M had ... See full document
13
V3 Recombinants Indicate a Central Role for CCR5 as a Coreceptor in Tissue Infection by Human Immunodeficiency Virus Type 1
... the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 to both CD4 and one of several chemokine receptors (coreceptors) permits entry of virus into ... See full document
9
Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1.
... CD4 1 T-cell depletion remains a key unexplained charac- teristic of acquired immunodeficiency, which predisposes the patient to lethal infectious and neoplastic complications of AIDS and for ... See full document
9
Kinetics of Antiviral Activity by Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL) and Rapid Selection of CTL Escape Virus In Vitro
... progeny virus has started. Yet, virus replication in freshly isolated PBMC was significantly suppressed by CTL against the Rev protein, which resulted in the rapid selection of CTL escape ... See full document
7
Evolution of Human Immunodeficiency Virus Type 1 in a Patient with Cross-Reactive Neutralizing Activity in Serum
... of rapid replication dynamics (9, 36) in combination with an error- prone reverse transcriptase and lack of proofreading, contrib- utes to its high genetic variability and the continuous emer- gence of new viral ... See full document
6
Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1.
... with human immunodeficiency virus type 1 (HIV-1) has been described for gibbons (19), pig-tailed macaques (1), and chimpanzees (3, ...the virus over extended ... See full document
6
Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor
... replication-competent virus that lacks the T242N mutation (7, ...is selection for and mainte- nance of escape mutations that have a negative impact on ... See full document
16
Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS
... several recombinants with the functional NA7 nef allele (30) ...nef recombinants on CD4 cell surface expression, all forms effi- ciently downregulated class I MHC ... See full document
9
Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS.
... disease progression was also seen for the same patients when the MMS measure was used ...10 AIDS patients showed low proviral diversity (entropy, , ...CD4 1 counts showed high diversity (entropy, ... See full document
11
Pseudodiploid Genome Organization Aids Full-Length Human Immunodeficiency Virus Type 1 DNA Synthesis
... (Fig. 1). Coexpression of p CMV Lac SV40 Puro with HIV-1 helper function plasmids in 293T cells produced viral particles that each contained two copies of the CMV Lac SV40 Puro vector ... See full document
9
Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection
... primary human immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied the evolution of the C2-V5 region of the HIV-1 env gene and of ... See full document
14
Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand.
... Primary virus isolates were obtained from twenty-two hos- pitalized patients with AIDS from northern ...earliest virus samples that were positive (within 2 to 3 weeks after coculture) were used for ... See full document
7
Patterns of Human Immunodeficiency Virus Type 1 Recombination Ex Vivo Provide Evidence for Coadaptation of Distant Sites, Resulting in Purifying Selection for Intersubtype Recombinants during Replication
... intersubtype recombinants disrupted the linkages of the coadapted sequences, causing a decrease in viral replication ...Intersubtype recombinants in which epistatic pairs of mutations are separated from one ... See full document
11
Rapid Reversion of Sequence Polymorphisms Dominates Early Human Immunodeficiency Virus Type 1 Evolution
... within 1 year of infection could be mapped onto previously described CTL epitopes restricted by each subject’s HLA alleles ...HLA type, 15% of the forward mutations fell into this group and reached ... See full document
9
Rapid culture and quantitation of human immunodeficiency virus type 1 from patient cells without the use of mitogen-stimulated donor cells.
... To compare numbers of HIV-infected cells defined by the rapid-culture assay and the 21-day coculture assay, the stan- dard curves produced for chronically infected Ul and ACH-2 cell line[r] ... See full document
7
Use of Patient-Derived Human Immunodeficiency Virus Type 1 Integrases To Identify a Protein Residue That Affects Target Site Selection
... sarcoma virus integrase (1, 2, 12, 26), and some data suggest that all three conserved active-site residues may coordinate two metal ions (1, ...the selection of nonviral target DNA sites have ... See full document
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