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[PDF] Top 20 Selection of T1249-Resistant Human Immunodeficiency Virus Type 1 Variants

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Selection of T1249-Resistant Human Immunodeficiency Virus Type 1 Variants

Selection of T1249-Resistant Human Immunodeficiency Virus Type 1 Variants

... HIV-1 variants resistant to T1249 in ...in T1249 resis- ...the virus can perhaps easily compensate for point mutations, and therefore mutations at the docking site of the peptide ... See full document

11

Identification of a Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Variant Resistant to Cold Inactivation

Identification of a Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Variant Resistant to Cold Inactivation

... Each virus preparation was divided into two por- tions, one kept at ⫺ 80°C and the other placed on ...h, virus was pelleted and pellets and supernatants were used for precipitation of viral proteins by an ... See full document

13

Gag Regulates Association of Human Immunodeficiency Virus Type 1 Envelope with Detergent-Resistant Membranes

Gag Regulates Association of Human Immunodeficiency Virus Type 1 Envelope with Detergent-Resistant Membranes

... Envelope association with lipid rafts is eliminated in the absence of the Gag precursor. We first investigated whether HIV-1 envelope required other viral proteins to associate with DRMs. Envelope was expressed ... See full document

9

Induction of T-Cell Immunity to Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1

Induction of T-Cell Immunity to Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1

... cohort. Human Research Ethics approval was granted to conduct this ...(Table 1). Genotyping of the RT and protease genes of the predominant HIV-1 species in plasma was kindly performed by Chris Birch ... See full document

10

Persistence and Fitness of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Acquired in Primary Infection

Persistence and Fitness of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Acquired in Primary Infection

... primary human immunodeficiency virus infection ...(WT) virus within 12 weeks of treatment ...patient 1 at week 52 was associated with the de novo emergence of a protease ... See full document

9

Relative Replicative Fitness of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Isolates In Vitro

Relative Replicative Fitness of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Isolates In Vitro

... treat human immunodeficiency virus type 1 (HIV-1) infection appear to result in the selection of drug-resistant mutants, which ultimately limits the benefits of ... See full document

6

Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.

Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.

... Therefore, selection pressure on HIV-1 is minimal or nonexistent because the virus can replicate in transduced cells with ineffective td PR expression levels, sup- porting the concept of combination ... See full document

8

Passive Sexual Transmission of Human Immunodeficiency Virus Type 1 Variants and Adaptation in New Hosts

Passive Sexual Transmission of Human Immunodeficiency Virus Type 1 Variants and Adaptation in New Hosts

... where selection pressures are ...CTL-induced selection pressure is acting on at least one intraepitope ...wild type in non-HLA-B51 patients, as well as reflecting early ...simian ... See full document

9

Neutralization Escape Variants of Human Immunodeficiency Virus Type 1 Are Transmitted from Mother to Infant

Neutralization Escape Variants of Human Immunodeficiency Virus Type 1 Are Transmitted from Mother to Infant

... simian-human immunodeficiency virus ...simian-human immunodeficiency virus ...of virus, and one that is sensitive to neutralization by these antibodies (2, 10, 17), it is ... See full document

11

Selection for Human Immunodeficiency Virus Type 1 Recombinants in a Patient with Rapid Progression to AIDS

Selection for Human Immunodeficiency Virus Type 1 Recombinants in a Patient with Rapid Progression to AIDS

... of random genetic drift with different population sizes, N, assuming a generation time of 1.78 days (23). To mimic sam- pling variation, the simulated sequences were sampled accord- ing to the scheme used for collecting ... See full document

11

3′-Azido-3′-Deoxythymidine (AZT) Mediates Cross-Resistance to Nucleoside Analogs in the Case of AZT-Resistant Human Immunodeficiency Virus Type 1 Variants

3′-Azido-3′-Deoxythymidine (AZT) Mediates Cross-Resistance to Nucleoside Analogs in the Case of AZT-Resistant Human Immunodeficiency Virus Type 1 Variants

... wild-type virus or to HIV-1 carrying only the K70R ...HIV- 1 to overcome any inhibitory effects of ...was resistant to each of 29,39-didehydro-29,39- deoxythymidine (d4T), ddI, and ddC, ... See full document

8

R5 Variants of Human Immunodeficiency Virus Type 1 Preferentially Infect CD62L− CD4+ T Cells and Are Potentially Resistant to Nucleoside Reverse Transcriptase Inhibitors

R5 Variants of Human Immunodeficiency Virus Type 1 Preferentially Infect CD62L− CD4+ T Cells and Are Potentially Resistant to Nucleoside Reverse Transcriptase Inhibitors

... HIV-1 variants in dif- ferent subsets of CD4 ⫹ T cells in ex vivo-infected human lym- phoid tissues and peripheral blood mononuclear cells ...influenza virus antigen in a mouse model ex- ... See full document

12

Selection of a Simian-Human Immunodeficiency Virus Strain Resistant to a Vaginal Microbicide in Macaques

Selection of a Simian-Human Immunodeficiency Virus Strain Resistant to a Vaginal Microbicide in Macaques

... for selection/infection by HIV or SHIV resistant to a vaginally applied ...the selection of PSC-RANTES-resistant virus was only identified in 1 of 25 macaques vaginally treated ... See full document

10

Effect of different donor cells on human immunodeficiency virus type 1 replication and selection in vitro.

Effect of different donor cells on human immunodeficiency virus type 1 replication and selection in vitro.

... vitro selection, as well as those influencing viral transmission in vivo, are not fully ...the virus from immune system selective pressures, such as neutralizing antibodies ...cause selection in vivo ... See full document

8

Real Time PCR Assay of Individual Human Immunodeficiency Virus Type 1 Variants in Coinfected Human Lymphoid Tissues

Real Time PCR Assay of Individual Human Immunodeficiency Virus Type 1 Variants in Coinfected Human Lymphoid Tissues

... Real-time quantitative RT-PCR assay. We evaluated the viral replication of each of the HIV-1 variants (SF162, LAV.04, 89-v345.SF, and 89.6) by means of quantitative real-time PCR by using the ABI Prism 7700 ... See full document

6

Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies

Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies

... of human immunodeficiency virus type 1 (HIV-1) ...RT variants for their ability to influence virus mutant ...RT variants tested included ... See full document

10

Primary Isolates of Human Immunodeficiency Virus Type 1 Are Usually Dominated by the Major Variants Found in Blood

Primary Isolates of Human Immunodeficiency Virus Type 1 Are Usually Dominated by the Major Variants Found in Blood

... viral variants observed in culture are due to competition between variants with different replicative fitness ...balancing selection between variants with high replicative fitness and ... See full document

10

Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors.

Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors.

... but resistant variants show considerable decreases in viral ...highly resistant to BILA 1906 BS and BILA 2185 BS, however, also contain cleavage site mutations, which were shown to be better ... See full document

8

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.

... We show that a single amino acid substitution Arg to Gln or Lys at position 8 of the protease results in a substantial decrease in the inhibitory activity of the drug on the enzyme and a[r] ... See full document

5

Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1

Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1

... of human immunodeficiency virus type 1 (HIV-1) mutants selected by different protease inhibitors (PIs) in vivo was ...wild type (WT), NL4-3, in the absence of drugs by ... See full document

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