[PDF] Top 20 Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study
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Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study
... Six SNPs either within the TERT gene or the 5-kb prox- imal promoter region were genotyped as previously de- scribed [25]. The TERT SNPs were among a panel of nearly 49,000 SNPs in 2,100 genes associated with car- ... See full document
10
Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas
... A total of 69 (36 soft tissue MFHs, 24 LSs and 9 bone MFHs) sarcoma samples were obtained at the time of surgery, were immediately frozen and stored at -80°C until commencement of our study. Summarized clinical ... See full document
9
Post-transcriptional regulation of telomerase reverse transcriptase (TERT) in human embryonic stem cells cultured under varying oxygen microenvironments
... this study we set out to determine the dynamic interaction between hESCs and their microenvironment and the subsequent effects on extra-telomeric role(s) of telomerase in human embryonic stem cell potency ... See full document
110
Somatic mutations in telomerase promoter counterbalance germline loss of function mutations
... in telomerase reverse transcriptase (TERT) in blood leukocytes of approximately 5% of individuals with inherited loss-of-function coding mutations in TERT or poly(A)-specific ribonuclease (PARN), ... See full document
6
INSILICO SCREENING OF NNRTI AS POTENTIAL TARGETS FOR TUMOR CONTROL
... of reverse transcriptase activity as seen in HIV-1 ...against telomerase inhibition. In this insilico study based on dock score and interactions with RT domain, some NNRTI’s seem to be ... See full document
15
The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... Interestingly, the rs2736100 polymorphism was identi- fied in the promoter region of the hTERT gene and was considerably associated to postoperative recurrence of TC patients. It has been reported that hTERT promoter ... See full document
9
Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase
... The multipotency of stem cells was proposed as the potential mechanism for the therapeutic effect on restoring erectile function in rats. Stem cells transplanted into rat corpus cavernous have the potential to ... See full document
14
Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas: Clinicopathological correlates
... our study we found that for those cases that carried 1p/19q co- deletion and had ATRX immunohistochemistry done, there was no loss of ATRX seen on ...our study, there was a significant association between ... See full document
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Telomerase reverse transcriptase methylation predicts lymph node metastasis and prognosis in patients with gastric cancer
... Between 2007 and 2009, 116 patients with GC were treated at Shanghai Cancer Center of Fudan University. All patient- derived specimens were collected and archived under protocols approved by the Institutional Review ... See full document
8
Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer
... this study is to investigate the role of human telomerase RNA (hTR), human telomerase reverse transcriptase (hTERT) and CDC28 protein kinase regulatory subunit 2 (CKS2) in bladder ... See full document
10
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression
... our study also represents a significant advance- ment in the field of general transcription, as it shows that several oncogenic pathways may be utilizing this housekeeping transcrip- tion machinery to drive ... See full document
17
Human telomerase reverse-transcriptase promoter-controlled and herpes simplex virus thymidine kinase-armed adenoviruses for renal cell carcinoma treatment
... of kidney cancer, reporting a positive rate of 78.9% in RCC tumor tissues and 0% in adjacent tissues. These results iden- tify hTERT expression as a specific characteristic of RCC cells, a finding consistent with the ... See full document
8
HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
... particular sequence contains an excess of APOBEC-associated mutations or of very rare amino acid variants can be used to optimally determine the signifi- cance of other mutations present in that sequence, ... See full document
13
Original Article MicroRNA-138 suppresses cell proliferation of human malignant melanoma cells by targeting hTERT
... present study was to investigate the functional significance of miR-138 and to identify its target genes in MM ...human telomerase reverse transcriptase (hTERT) as a direct target gene of ... See full document
10
Original Article Screening and identification of antisense accessible sites of the human telomerase reverse transcriptase gene in prostate cancer cell lines
... RNase H digestion and screening, the best significant stem-loop structures of the region were designated as the best antisense binding sites. We based these best binding sites on the stem-loop structures because we ... See full document
11
Telomerase regulates MYC driven oncogenesis independent of its reverse transcriptase activity
... first study to our knowledge to experimentally demonstrate that a feed-forward transcriptional loop between MYC and TERT exists in cancers and that this loop is functionally critical for ...augmenting ... See full document
15
Expression of Telomerase Reverse Transcriptase during the Malignant Transformation of Cadmium Induced Cells
... present study was to investigate human telomerase reverse transcriptase (hTERT) mRNA and protein expressions during the cadmium chloride-induced malignant trans- formation of human bronchial ... See full document
5
Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
... and telomerase regulation by TERT p Mut [22, 30, 39, ...binding sequence (CCGGAA) at the E-twenty-six/ternary complex (ETS/ TCF) transcription factors ...of telomerase [88, ... See full document
12
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
... and telomerase during hematopoiesis cannot be inferred simply from a single animal model but needs to be studied comparatively in several vertebrate species, as well as directly in human ...only telomerase, ... See full document
21
Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population
... Telomerase reverse transcriptase (TERT) is a gene within the cancer susceptibility region located at ...this study, we validated the association between TERT polymorphisms and gastric cancer ... See full document
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