[PDF] Top 20 Simian Immunodeficiency Virus Integration Preference Is Similar to That of Human Immunodeficiency Virus Type 1
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Simian Immunodeficiency Virus Integration Preference Is Similar to That of Human Immunodeficiency Virus Type 1
... require integration into the host cell genome for completion of the replication cycle of the ...which integration sites are selected by retroviruses remains poorly ...retrovirus integration, but the ... See full document
6
Similar Levels of Human Immunodeficiency Virus Type 1 Replication in Human TH1 and TH2 Clones
... In vitro synthesis of HIV-1 RNA. HIV-1 RNA synthesized from a DNA template produced by the amplification of HIV-1 proviral DNA by using mod- ified HIV-1 gag region-specific primers SK38 and ... See full document
8
Human Immunodeficiency Virus Type 2 Produces a Defect in CD3-γ Gene Transcripts Similar to That Observed for Human Immunodeficiency Virus Type 1
... of HIV-1-infected WE17/10 cells was previously shown, by RNA dot and Northern blot hybridization (84), to result from a specific defect in CD3-g gene transcripts. In this study, RNA dot blot hybridization was used ... See full document
7
Cofactors for Human Immunodeficiency Virus Type 1 cDNA Integration In Vitro
... around 1 NC molecule per 5 to 15 bp, potentially enough to coat the reactant ...ulates integration by competing with IN binding at nonproduc- tive internal sites on the DNA (6, 15, ...a similar ... See full document
6
Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection.
... infect human HeLa-CD4 (MAGI) cells. MAGI cells can be infected by T-tropic HIV-1 isolates, but not M-tropic HIV-1 (26), sug- gesting that HeLa cells may not express CCR-5 but do express CXCR-4 or ... See full document
8
Evaluation of Cytotoxic T-Lymphocyte Responses in Human and Nonhuman Primate Subjects Infected with Human Immunodeficiency Virus Type 1 or Simian/Human Immunodeficiency Virus
... Fig. 1, one-tenth of the PBMC sample used for bulk culture was infected with recom- binant vaccinia virus expressing SIV Gag and then recombined with the remaining PBMC in culture for 2 ...inactivate ... See full document
10
Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1
... high virus loads and disease progression in a workable time frame in 100% of the ...the human cellular partners for which it has ...actually similar to the vari- able viral loads and disease ... See full document
12
Chimeric Human Immunodeficiency Virus Type 1 Virions That Contain the Simian Immunodeficiency Virus nef Gene Are Cyclosporin A Resistant
... activated human PBMCs with 10 ng of WT R7 virus or R7SIVnef ⫹ in either the presence or absence of ...0, 1, 3, 5, 7, 9, and 12 days, and p24 antigen content was determined by enzyme-linked immunosor- ... See full document
6
Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model
... It is important to note that during the 16-week observation period, none of the four animals experienced a dramatic de- cline in the CD4 lymphocyte count. This result is not totally unexpected because the SHIVs that have ... See full document
9
Importin 7 May Be Dispensable for Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Infection of Primary Macrophages
... possible plasmid DNA carryover and subjected to real-time PCR in order to quantify 2LTR circles (forward primer, TAG ACCAGATCTGAGCCTGGGA; reverse primer, GTAGTTC TGCCAATCAGGGAAG), late viral cDNA products (late cDNAs; ... See full document
6
Regulation of APOBEC3 Proteins by a Novel YXXL Motif in Human Immunodeficiency Virus Type 1 Vif and Simian Immunodeficiency Virus SIVagm Vif
... tested the ability of these mutants to bind recombinant His- A3G in a GST pull-down assay. The Y69A and W70A mutants bound only trace amounts of His-A3G, while the H42,43N mutant bound similar amounts of His-A3G ... See full document
8
Human Immunodeficiency Virus Type 1 Modified To Package Simian Immunodeficiency Virus Vpx Efficiently Infects Macrophages and Dendritic Cells
... stomatitis virus glycoprotein (VSV-G) pseudotypes in 293T cells cotransfected with increas- ing amounts of ...wild-type virus that lacked Vpx was poorly ...this virus with Vpx slightly ... See full document
12
Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles
... and similar findings by others using prime and boost regimens to control the postpeak viremia attending virus challenges with highly pathogenic SHIVs ap- pear to be encouraging advancements in the quest to ... See full document
12
Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus.
... the integration step in the retrovirus life cycle had to be totally suppressed if disease was to be ...however, virus loads may be substantially reduced and the onset of disease may be significantly delayed ... See full document
8
Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees
... long-term human survivors recognize the same or similar epitopes but are restricted by different major histocompatibility complex class I alleles ... See full document
11
Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Nef Proteins Show Distinct Patterns and Mechanisms of Src Kinase Activation
... possess similar functional properties, including an ability to enhance viral replication and infectivity (1, 39), to modulate cell surface receptors (5, 37), and to alter cellular signal transduction ... See full document
7
Common Themes of Antibody Maturation to Simian Immunodeficiency Virus, Simian-Human Immunodeficiency Virus, and Human Immunodeficiency Virus Type 1 Infections
... of virus-specific antibodies to SIV envelope antigens, this study revealed for the first time similar patterns of evolution of envelope-specific antibodies in response to SHIV infection during the first ... See full document
8
A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.
... cell type. nef-dependent virus replication and cellular ...is similar to numerous earlier experiments in which nef1 and nef2 SIVmac239 replicated indistinguishably in CEMx174 cells and in ... See full document
6
Ubiquitin Is Covalently Attached to the p6GagProteins of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus and to the p12Gag Protein of Moloney Murine Leukemia Virus
... (10%) similar to those that we have found inside ...leukosis virus Gag originally was conjugated to ubiquitin but was removed inside the virion and is detected as free ubiquitin in the ... See full document
7
Consistent Patterns of Change during the Divergence of Human Immunodeficiency Virus Type 1 Envelope from That of the Inoculated Virus in Simian/Human Immunodeficiency Virus-Infected Macaques
... Sequence analysis. Sequences were assembled using Lasergene DNAstar Seqman and Editseq (2) and aligned with ClustalX (58). Nucleotide alignments were manually edited using BioEdit 5.0.9 (27). A maximum likelihood tree of ... See full document
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