[PDF] Top 20 Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... on apoptosis of neurons during ...which latency has been established, the trigeminal ganglia of mice from this time point were used for our apoptosis ...LAT-positive ... See full document
7
Relaxed Repression of Herpes Simplex Virus Type 1 Genomes in Murine Trigeminal Neurons
... with herpes simplex virus (HSV) in vivo occurs in three stages: primary (productive) infection, latency, and reac- ...the virus replicates and produces progeny in susceptible epithelial ... See full document
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The Locus Encompassing the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Interferes with and Delays Interferon Expression in Productively Infected Neuroblastoma Cells and Trigeminal Ganglia of Acutely Infected Mice
... delayed expression of IFN- ␣ 4 RNA and reduced the frequency of IFN- ␣ 4 RNA in TG of infected mice is significant because IFN- ␣ 4 expression is an “immediate early” response to virus infection ... See full document
10
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... Latency-associated transcript (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in ... See full document
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... reactivation from latency. We suggest that LAP2-driven expression of LAT may play a role in sup- pressing ICP0 production during lytic infection, thereby assist- ing the virus in establishing ... See full document
10
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
10
Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for the high spontaneous and induced reactivation phenotype of ... See full document
6
Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... Herpes simplex virus type 1 latency associated transcript is plentifully expressed through virus ...gene expression analysis showed that LAT ... See full document
8
Herpes Simplex Virus Type 1 Vector-Mediated Expression of Nerve Growth Factor Protects Dorsal Root Ganglion Neurons from Peroxide Toxicity
... injury from cell lysates of either mock-infected or vector-infected nondissociated pri- mary DRG neuronal cultures following hydrogen peroxide ...49). Expression of NGF from the HCMV IEp vector SHN ... See full document
14
Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... latent virus and facilitate efficient reactivation (19, ...promote apoptosis, it is thought that LAT functions to reduce the programmed cell death triggered during reactiva- ...against apoptosis ... See full document
13
Reactivation of Herpes Simplex Virus Type 1 in the Mouse Trigeminal Ganglion: an In Vivo Study of Virus Antigen and Cytokines
... of herpes simplex virus (HSV-1) to reactivate from latency in sensory ganglia is central to the pathogenesis of recurrent ...such neurons is still ...the trigeminal ... See full document
7
Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... the latency- reactivation cycle has been identified, suggesting that LAT regu- lates the latency-reactivation cycle by exerting its effect as an RNA molecule rather than by directing production of a ... See full document
11
A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... blocking virus-induced apoptosis in neurons, we propose two additional potential mechanisms that we feel are worthy of ...to apoptosis. In fact, it is possible that the initiation of ... See full document
10
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...During latency, transcription is restricted ... See full document
10
A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... and latency was ...long-term expression of a foreign protein in the eye (LR protein with ...wild type-infected rabbits because LAT does not appear to encode a ...more virus in the eye ... See full document
12
Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... lishes latency in trigeminal ganglia (TG), while HSV-2 usually infects the genital epithe- lium and establishes latency in dorsal root ganglia (DRG) ...and neurons therein are specialized in ... See full document
15
Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... gene expression during HSV-1 latency (20, ...transcripts from genes encoding the immediate-early viral protein ICP4 and the early viral protein thymidine kinase (TK) in latently infected ... See full document
12
Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection.
... Following herpes simplex virus type 1 (HSV-1) infection of the cornea, the virus is transmitted to the trigeminal ganglion, where a brief period of ... See full document
8
Structural and kinetic analyses of herpes simplex virus type 1 latency associated transcripts in human trigeminal ganglia and in cell culture
... human trigeminal ganglia, the smaller (1.35 kb) HSV-1 transcript differs from the larger ...Its expression is inhibited by cycloheximide or acyclovir, indicating this LAT is synthesized ... See full document
8
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... and herpes simplex virus type 1 ...Sensory neurons are permissive for viral replication, yet the virus can also enter a latent state in these ...The ... See full document
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