[PDF] Top 20 Somatic mutations in cancer development
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Somatic mutations in cancer development
... a cancer cell takes place through a sequence of a small number of discrete genetic events, somatic muta- tions (Figure 7): thus, cancer can be regarded ... See full document
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Erratum to: Somatic mutations in cancer development
... a cancer cell takes place through a sequence of a small number of discrete genetic events, somatic mutations: thus, cancer can be regarded properly as a genetic disease of somatic ... See full document
8
Only one health, and so many omics
... in cancer are provid- ing us with information often referred to in a number of scientific papers as genomic landscapes of cancer [13, ...plex cancer system ...National Cancer Institute and ... See full document
7
DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes
... the development of lung can- cer in never smokers, we applied DOTS-Finder to the somatic mutations of the 50 never smoker patients present in the LUAD samples of the ...well-known cancer genes ... See full document
13
Statistical Analysis of Pathogenicity of Somatic Mutations in Cancer
... for somatic mutations in human cancers have been ...driver mutations in cancer genes that are causally implicated in cancer development (F utreal et ...these cancer genes ... See full document
12
Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer.
... whether somatic reversion mutations would be detected in ctDNA of PARP inhibitor- and/or platinum-resistant advanced breast cancer patients harboring BRCA1 (n=1) or BRCA2 (n=4) germline ...analyzed ... See full document
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The prognostic effects of somatic mutations in ER-positive breast cancer.
... status and non-silent (Supplementary Figure 7A) as well as FS/NS mutations in GATA3 (Supplementary Data 218... Considering q values of <0.2 the associations between FS/NS and 220.[r] ... See full document
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CVE: an R package for interactive variant prioritisation in precision oncology
... many somatic mutation calling ...other cancer samples), a subset of which were frequently altered in can- ...Similarly, mutations in DNA damage repair genes can be included in further analysis using ... See full document
12
Depletion of somatic mutations in splicing associated sequences in cancer genomes
... non-synonymous mutations is not long enough ...sense mutations is problematic as this fails to allow for the fact that heterozygous nonsense mutations can be buffered by nonsense mediated ... See full document
12
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
... rare mutations by Kim et ...functional mutations (Additional file 8: Table ...K134N mutations that were validated as functional by Kim et ...these mutations as statistically ... See full document
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NeoMutate: an ensemble machine learning framework for the prediction of somatic mutations in cancer
... VarScan2 [12] and VarDict [13], apply a heuristic meth- odology followed by a Fisher’s test to increase the reliabil- ity of the detected somatic variants. An appropriate parameter fine-tuning and threshold ... See full document
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Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans
... missense mutations in KRAS and TP53 (and in any gene) can be accounted for by the strong mutator phenotype displayed by these tumors, in CRC without MSI the origin of these oncogenic mutations remains ... See full document
12
Next generation sequencing
... potential mutations that drive specific subtypes of complex and heterogeneous diseases such as leukaemias and breast cancer, and has demonstrated how the mutational spectrum of a cancer evolves over ... See full document
7
Pharmacogenomic analysis of patient derived tumor cells in gynecologic cancers
... 24]. Somatic variants were determined though exome sequencing (median of 20 genomic variants per sample), and only mutations with variant allele frequency of > 5% were ...TP53 somatic ... See full document
13
Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
... of mutations in cancer ...of cancer-derived DNA to microarrays and other approaches provided higher resolution insights into copy number ...mutated cancer genes and mutational processes ... See full document
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Mutation analysis of the adenomatous polyposis coli gene
... of mutations in various genes. This is implied by the increase in cancer prevalence that occurs with ...the development of cancer (Miller, 1980). If cancer were the consequence o f a ... See full document
313
Discovering cancer genes by integrating network and functional properties
... NAs from these six genes, 13 caused significant reduction of cell viability in DLD-1 (p < 0.05, noted by '*' in Figure 6). BMX, BMPR1B, BTK, and MDC1 belong to the COSMIC_mut gene set, and CSNK2A2 belongs to the ... See full document
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MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis
... of Somatic Mutations in Cancer (COSMIC) database ...the Cancer Gene Census (CGC) [32] col- lection and found that among the 183 CGC genes that had been detected through SNV/indel analyses in ... See full document
16
Age-related somatic mutations in the cancer genome
... post-tumorigenesis mutations affecting the results, and the possibility that the mutation frequencies in exomes are not representative of the genome as a ...accumulate mutations in cells within the tumor, ... See full document
9
The search for cis -regulatory driver mutations in cancer genomes
... of somatic cis-regulatory mutations in cancer is still in its infancy, with only a handful of studies performed to date, for examples see [6, 51–54, 56, ...candidate mutations for further ... See full document
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