[PDF] Top 20 Strain-specific neutralizing determinant in the transmembrane protein of simian immunodeficiency virus.
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Strain-specific neutralizing determinant in the transmembrane protein of simian immunodeficiency virus.
... This strain-specific neutralizing determinant is located within a variable region of SIVmac and human immunodeficiency virus type 2 HIV-2 which includes conserved, clustered sites for N-[r] ... See full document
9
Evidence against Extracellular Exposure of a Highly Immunogenic Region in the C-Terminal Domain of the Simian Immunodeficiency Virus gp41 Transmembrane Protein
... human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein topology includes a sin- gle membrane-spanning ...in simian immunodeficiency virus SIVmac239-infected rhesus macaques ... See full document
13
CD4-Independent Entry and Replication of Simian Immunodeficiency Virus in Primary Rhesus Macaque Astrocytes Are Regulated by the Transmembrane Protein
... pivotal determinant of viral tropism; viruses that utilize CCR5 are generally macrophage tropic, those that use CXCR4 are lymphocyte tropic, and those that utilize both CCR5 and CXCR4 are considered dual tropic ... See full document
8
Truncations of the simian immunodeficiency virus transmembrane protein confer expanded virus host range by removing a block to virus entry into cells.
... Virions containing the wild-type and mutant glycoproteins were capable of efficient replication in macaque peripheral blood lymphocytes and CEMX174 cells; in contrast, only virions that [r] ... See full document
10
The Intracytoplasmic Domain of the Env Transmembrane Protein Is a Locus for Attenuation of Simian Immunodeficiency Virus SIVmac in Rhesus Macaques
... free virus stocks of SIVmac-M1 and SIVmac-M4 on CEMx174 cells and used these to infect primary PBMC obtained prior to initiation of the study from each of the eight juvenile macaques that were later inoculated ... See full document
9
The cytoplasmic domain of simian immunodeficiency virus transmembrane protein modulates infectivity.
... We investigated the function of the SIVmac envelope cytoplasmic domain by replacing the in-frame stop codon by 4395 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest A st[r] ... See full document
9
Glycosylation of gp41 of Simian Immunodeficiency Virus Shields Epitopes That Can Be Targets for Neutralizing Antibodies
... with neutralizing activity against the parental wild-type strain SIVmac239 (32, ...with neutralizing activity ...gp41 transmembrane subunit have not to our knowledge been previously ... See full document
15
Neutralizing Capacity of Monoclonal Antibodies That Recognize Peptide Sequences Underlying the Carbohydrates on gp41 of Simian Immunodeficiency Virus
... The neutralizing activities of MAbs 4G8, 6G8, and 7D6 against various strains of SIVmac were measured using the im- mortalized human CD4 ⫹ T-cell line C8166-45 SIV-SEAP ...supernatant. Virus amounts ... See full document
10
Importance of the V1/V2 Loop Region of Simian-Human Immunodeficiency Virus Envelope Glycoprotein gp120 in Determining the Strain Specificity of the Neutralizing Antibody Response
... human immunodeficiency virus type 1 (HIV-1) are known to be highly strain specific in their ability to neutralize HIV-1 ...significant neutralizing activity against autologous HIV-1 ... See full document
13
Identification of the V1 region as a linear neutralizing epitope of the simian immunodeficiency virus SIVmac envelope glycoprotein.
... neutralization determinant of HIV-1 is located within the third variable do- main (V3) of the external glycoprotein gp120 (13, 31, 45, ...neutralization determinant was shown (14, 20, ...linear ... See full document
7
Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection
... of neutralizing antibody (NAb) responses are characteristics of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infec- ...of ... See full document
11
Identification of the LWYIK Motif Located in the Human Immunodeficiency Virus Type 1 Transmembrane gp41 Protein as a Distinct Determinant for Viral Infection
... Construction of LWYIK motif mutants. For cloning purposes, the HindIII site located at nucleotide position 6027 of the HXB2 provirus was destroyed by the PCR overlap extension method. The EcoRI- and StuI-cut PCR product ... See full document
14
An Orphan Seven-Transmembrane Domain Receptor Expressed Widely in the Brain Functions as a Coreceptor for Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
... stomatitis virus G-protein cytoplasmic domain in place of the normal ...measure virus infection involved a PCR- based entry ...free virus was used to infect QT6 cells stably expressing human ... See full document
7
Outcome of Simian-Human Immunodeficiency Virus Strain 89.6p Challenge following Vaccination of Rhesus Macaques with Human Immunodeficiency Virus Tat Protein
... Vaccination studies performed with rhesus or cynomolgus macaques have demonstrated protection or control against SHIV infection by using Tat protein, peptides, or DNA as immunogens. In rhesus macaques, although ... See full document
10
Induction of Mucosal Homing Virus-Specific CD8+ T Lymphocytes by Attenuated Simian Immunodeficiency Virus
... The mucosal immune system is functionally and phenotypi- cally distinct from the peripheral immune system (3, 20). In- duction of immune responses by peripheral immunization at cutaneous or intramuscular sites results in ... See full document
5
Neutralizing IgG at the Portal of Infection Mediates Protection against Vaginal Simian/Human Immunodeficiency Virus Challenge
... of virus by migratory cells emigrating from tissue ...T/F virus, as opposed to 1 to 4 T/F viruses in the controls, more animals would be needed to draw firm conclusions about viral con- ... See full document
13
Virus Subtype-Specific Features of Natural Simian Immunodeficiency Virus SIVsmm Infection in Sooty Mangabeys
... The trees are based on gag (500-bp) (a), pol (592-bp) (b), and env (405-bp) (c) fragments after gap-containing sites have been removed. The phylogenetic trees were estimated by the neighbor-joining method on amino acid ... See full document
11
A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques
... replicated to high levels in vivo and more closely followed the patterns of the SIV strains with regard to peak levels of RNA in plasma. Animals infected with RT-SHIV also showed larger individual variations in peak ... See full document
5
Estimating the Impact of Vaccination on Acute Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections
... of virus to infect cells (“infectivity”), on the rate of virion production by infected cells, on the lifetime of infected cells, and on the rate at which free virus is ...create virus-specific ... See full document
10
Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus
... the virus (decrease of trimer stability and exposure of neutralizing epitopes [15–17, 19, 49]), this propensity is compensated by the strong contribution of layer 1 to trimer ... See full document
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