[PDF] Top 20 Structural basis of C3b binding by glycoprotein C of herpes simplex virus.
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Structural basis of C3b binding by glycoprotein C of herpes simplex virus.
... Superscripts: a, names of the mutants; b, amino acid residue number immediately preceding the insert; c, amino acids inserted at each site single-letter code Where insertion of the linke[r] ... See full document
15
Identification of C3b-binding regions on herpes simplex virus type 2 glycoprotein C.
... All of the mutants were expressed on the transfected cell surface, produced proteins with similar electrophoretic mobility to wild-type gC-2, and bound one or more MAbs that recognize di[r] ... See full document
10
C3b receptor activity on transfected cells expressing glycoprotein C of herpes simplex virus types 1 and 2.
... There are several possible explanations for the absence of receptor activity in these mutant proteins: i residues 219 to 244 and 318 to 346 are contact residues in the C3b-binding site; [r] ... See full document
10
Disulfide bond structure determination and biochemical analysis of glycoprotein C from herpes simplex virus.
... for C3b binding ...and C3b is highly dependent on the proper conformational structure of gC (17, ...forms C3b binding region I (Fig. 8). While C3b binding regions II and ... See full document
12
The Major Neutralizing Antigenic Site on Herpes Simplex Virus Glycoprotein D Overlaps a Receptor-Binding Domain
... Herpes simplex virus (HSV) entry is dependent on the interaction of virion glycoprotein D (gD) with one of several cellular ...various C-terminal truncations and (ii) a series of gD ... See full document
12
Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4.
... 4, an ICP4-binding site in the leader is required for activation if additional downstream binding sites are removed; ii the downstream ICP4-binding sites, which are located in the tk gen[r] ... See full document
13
Localization of a Binding Site for Herpes Simplex Virus Glycoprotein D on Herpesvirus Entry Mediator C by Using Antireceptor Monoclonal Antibodies
... Detection of HveC on the cell surface. We used FACS anal- ysis to test the ability of each CK MAb to detect HveC on CHO cells stably transfected with full-length human HveC cDNA (M3A cells) (Fig. 4B to F). Nontransfected ... See full document
10
Functional Region IV of Glycoprotein D from Herpes Simplex Virus Modulates Glycoprotein Binding to the Herpesvirus Entry Mediator
... of binding of gDt to HveAt with an optical ...nonspecific binding to the dextran matrix and changes in refractive index upon addition of sample, Fc2 was activated and then blocked without the addition of ... See full document
8
Structural and Antigenic Analysis of a Truncated Form of the Herpes Simplex Virus Glycoprotein gH-gL Complex
... We first transfected CHO-K1 cells with the gH C-terminal plasmids (Fig. 3). Culture supernatants and cytoplasmic (cell) extracts obtained from each transfection were immunoprecipi- tated with anti-gH MAb H6, ... See full document
12
Specificity and affinity of binding of herpes simplex virus type 2 glycoprotein B to glycosaminoglycans.
... Localization of gB binding on the MRC-5 cell surface and its inhibition by glycosaminoglycans. HSV-2 gB2-binding sites were localized on the surface of MRC-5 cells by incubation of live cells with ... See full document
6
Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E
... of binding to the tail of gE, both in vitro and within cotrans- fected ...the C-terminal deletion results in the creation of a totally new and irrelevant binding activity within the remaining ... See full document
12
Structural Basis for the Physiological Temperature Dependence of the Association of VP16 with the Cytoplasmic Tail of Herpes Simplex Virus Glycoprotein H
... inhibits binding to VP16 at temperatures lower that 37°C. At 37°C, the energy of thermal fluctuations is greater than the energy of the intramolecular interactions, and therefore the structure is ... See full document
8
Mapping of the structural gene for the herpes simplex virus type 2 counterpart of herpes simplex virus type 1 glycoprotein C and identification of a type 2 mutant which does not express this glycoprotein.
... Location of the gene for gF on the HSV-2 genome and the genes for gC 9, 14 and TK 17, 32 on the HSV-1 genome and a summary of the results obtained from screening AraTr viruses that conta[r] ... See full document
7
Monoclonal Antibodies to Distinct Sites on Herpes Simplex Virus (HSV) Glycoprotein D Block HSV Binding to HVEM
... FIG. 3. Model of gD antigenic structure and inhibition of HSV-1 binding to HVEMt by a panel of anti-gD MAbs. (A) Hypothetical folded model of gD based on epitope mapping studies (37) and solution of the disulfide ... See full document
7
Potential Nectin-1 Binding Site on Herpes Simplex Virus Glycoprotein D
... postreceptor binding conformations ...1. Structural models of gD and ...and C-terminal residues observed in the crystal structure are indicated in ...and C termini of HVEM observed in the ... See full document
14
Structural Basis of Local, pH-Dependent Conformational Changes in Glycoprotein B from Herpes Simplex Virus Type 1
... type. Glycoprotein B (gB) is a conserved component of the multiprotein herpesvirus fusion machinery and functions as a fusion protein, with two internal fusion loops, FL1 and ...of herpes simplex ... See full document
10
Molecular basis of the glycoprotein-C-negative phenotype of herpes simplex virus type 1 macroplaque strain.
... RNA transfer Northern blot analysis with hybridization probes from the region of the herpes simplex virus type 1 DNA known to encode the gC gene indicated that gC mRNA was produced in MP[r] ... See full document
8
Binding of complement component C3b to glycoprotein gC of herpes simplex virus type 1: mapping of gC-binding sites and demonstration of conserved C3b binding in low-passage clinical isolates.
... Received 4 April 1986/Accepted 8 July 1986 The sites on glycoprotein gC of herpes simplex virus type 1 HSV-1 which bind complement component C3b were evaluated by using i anti-gC monoclo[r] ... See full document
6
Binding of complement component C3b to glycoprotein C is modulated by sialic acid on herpes simplex virus type 1-infected cells.
... * 857 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Neuraminidase treatment of cells infected with herpes simplex virus type 1 HSV-1 markedly enhanced the binding of [r] ... See full document
5
Herpes simplex virus type 1-induced hemagglutination: glycoprotein C mediates virus binding to erythrocyte surface heparan sulfate.
... Finally, purified gC-1 protein, like whole HSV-1 virions, showed high hemagglutinating activity which was inhibited by heparan sulfate and/or heparin and was completely prevented by pret[r] ... See full document
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