[PDF] Top 20 Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.
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Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.
... In this study, a series of site-specific mutations of the human papillomavirus type 16 E7 gene product were constructed and assessed for their effects on intracellular protein stability,[r] ... See full document
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The Human Papillomavirus Type 16 E7 Oncoprotein Activates the Fanconi Anemia (FA) Pathway and Causes Accelerated Chromosomal Instability in FA Cells
... HPV-16 E7 in FANCD2 fibroblasts accelerates chromosomal ...HPV-16 E7-expressing immortalized FANCD2 ...HPV-16 E7-expressing immortalized human keratinocytes (B) or ... See full document
6
Mutational analysis of human papillomavirus type 11 E5a oncoprotein.
... Cys-X-Cys structure between HPV-11 E5a and BPV-1 E5 suggests that there may be a different mechanism behind the transformation by the E5 protein in each ...the structure of the E5 protein of BPV-1 is ... See full document
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Bovine Papillomavirus E7 Oncoprotein Inhibits Anoikis
... adherent human cells in which p600 protein expression was suppressed by small interfering RNA ...their analysis, a direct role for p600 in regulating integrin function was not directly ...identified. ... See full document
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Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human Keratinocytes
... ⫹ E7 cells contained high levels of p53 protein, there are compensatory cellular mecha- nisms that can functionally inactivate p53 transcriptional activ- ity and permit continued cell ...⫹ E7 cell line ... See full document
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Activation of Src, Fyn and Yes non receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein
... HPV 16 E7 expressing RKO colorectal carcinoma cell lines revealed, that HPV 16 E7 expression results in substantially altered kinase require- ments for viability of RKO cells ...HPV 16 ... See full document
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Chemical synthesis of human papillomavirus type 16 E7 oncoprotein: autonomous protein domains for induction of cellular DNA synthesis and for trans activation.
... DNA synthesis induction activity maps within the N-terminal portion of the molecule, which contains sequences related to adenovirus ElA conserved domains 1 and 2 required for cell transf[r] ... See full document
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The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes.
... mega Corporation (Madison, Wis.). The E5-containing mes- sages expressed from the vectors used in the subsequently described experiments are shown in Fig. 1B. The vector control plasmid pLXSN does not show any ... See full document
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Human Papillomavirus Type 16 E7 Oncoprotein Associates with E2F6
... immunoblot analysis for E2F6; E7 (using FLAG antibody) and actin blots are shown as ...indicate E7 proteins. (B) Effect of HPV6b, HPV11, HPV16, and HPV18 E7 on E2F6-mediated transcriptional ... See full document
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The Chromatin Structure of the Long Control Region of Human Papillomavirus Type 16 Represses Viral Oncoprotein Expression
... FIG. 5. Relief of nucleosomal transcriptional repression by trans-acting factors. (A) AP-1 (lanes 3 to 5) and Sp1 (lanes 8 to 10), added 15 min after initiation of chromatin assembly on pHPV-16-Luc, activate in ... See full document
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Detection of Human Papillomavirus Type 18 E7 Oncoprotein in Cervical Smears: a Feasibility Study
... of E7 to transform cells, the epitope does not encompass the Rb binding domain, representing one of the major functional interaction sites of ...the E7 N-terminal ...HPV18 E7 protein in clinical ... See full document
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Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Cullin 2 Ubiquitin Ligase Complex, Which Contributes to Degradation of the Retinoblastoma Tumor Suppressor
... HPV16 E7 oncoprotein associates with cullin ...HPV16 E7 oncoprotein, we expressed carboxyl terminally FLAG/HA epitope-tagged HPV16 E7 (C-E7) in HeLa cervical carcinoma cells and ... See full document
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Human Papillomavirus E7 Oncoprotein Dysregulates Steroid Receptor Coactivator 1 Localization and Function
... High-risk human papillomaviruses (HPVs) are present in virtually all cervical ...HPV type 16 (HPV16) E7 oncoprotein with steroid receptor coactivator 1 (SRC-1), an essential component ... See full document
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The Human Papillomavirus Type 16 E5 Oncoprotein Translocates Calpactin I to the Perinuclear Region
... In the preceding experiments, the pJS55 vector induced high levels of E5 expression in COS cells (29). To verify that the association of ANXA2, p11, and E5 occurred in stable lines derived from a natural HPV host cell in ... See full document
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Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16.
... Transformation assays performed with the E6 deletion mu- tants showed differences in their abilities to induce colonies, depending on their lengths (Fig. 5B). Deletion of amino acids 141 to 151 (M-141A) from the carboxy ... See full document
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Nonspecific Down-Regulation of CD8+T-Cell Responses in Mice Expressing Human Papillomavirus Type 16 E7 Oncoprotein from the Keratin-14 Promoter
... down-regulated E7-directed T-cell responses, as evidenced in vitro by dimin- ished CTL activity (14) and in vivo as failure to control E7- associated tumor development following specific immunization ... See full document
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Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein
... The human papillomaviruses (HPVs) designated as “high risk” types, such as HPV type 16 (HPV-16) and HPV-18, are associated with anogenital tract lesions that can progress to malignancy (44, ... See full document
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Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells
... other E7 C-terminal activities in the bypass of cell cycle ...the E7 C terminus was reported to function in conjunction with the Rb-binding motif to induce cdc25a ...of E7 to overcome ... See full document
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Interactions with Pocket Proteins Contribute to the Role of Human Papillomavirus Type 16 E7 in the Papillomavirus Life Cycle
... That E7 can inactivate pRb function without degrading pRb, as evidenced by the efficient induction of MCM7 in rafts of cells harboring wild-type or E7 ⌬PTLHE mutant HPV16 repli- cons, as well ... See full document
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Translation of the human papillomavirus type 16 E7 oncoprotein from bicistronic mRNA is independent of splicing events within the E6 open reading frame.
... and analysis of site-directed ...HPV-16 E7 from structurally bicistronic transcripts became ...of E7 translation? Second, by what mechanism was E7 translated from unspliced (and ... See full document
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