[PDF] Top 20 Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17.
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Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17.
... A particularly interesting mutant was the R39E,R43E dou- ble substitution. These arginine residues lie on the outside of helix A (Fig. 7B) and may well be part of the basic region that is involved in localization to the ... See full document
10
Differential membrane binding of the human immunodeficiency virus type 1 matrix protein.
... solution structure of p17MA, the basic domain forms an amphipathic b sheet exposed on the surface of the ...the structure of nonmyristylated p17MA is available and the extreme N terminus of p17MA is ... See full document
9
A Human Nuclear Shuttling Protein That Interacts with Human Immunodeficiency Virus Type 1 Matrix Is Packaged into Virions
... a 1:10,000 dilution of the appropriate horse- radish peroxidase-conjugated secondary antibody (Amersham) for 45 ...Mass.), 1:1,000; af- finity-purified rabbit anti-VAN, 1:100; anti-gp41 (T-32 ... See full document
14
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.
... from virus producer cells (data not shown). Tryptic peptide mapping studies revealed three major tryptic phosphopeptides of high chromatographic mobility in wild-type MA ... See full document
6
Cleavage of the Murine Leukemia Virus Transmembrane Env Protein by Human Immunodeficiency Virus Type 1 Protease: Transdominant Inhibition by Matrix Mutations
... MA function, we have fre- quently used MuLV Env pseudotypes to examine the pheno- types of MA ...The virus was initially obtained as a cell culture revertant (35) of a previously described mu- tant, 20LK ... See full document
7
Determinants of human immunodeficiency virus type 1 envelope glycoprotein oligomeric structure.
... influenza virus hemagglutinin transmembrane protein HA2 ...trimeric structure of hemagglutinin is stabilized primarily by hydropho- bic intermonomer interactions in the N-terminal half of the ... See full document
10
Effect of Ethanol on Monocytic Function in Human Immunodeficiency Virus Type 1 Infection
... (Fig. 1 and Table 5). This is similar to our previous studies demonstrating that HIV-1 infection of the human macrophage hybridomas was associated with loss of mRNA for IL-1a, IL-1b, and TNF-a ... See full document
9
Oligomeric Structure of the Human Immunodeficiency Virus Type 1 Envelope Protein on the Virion Surface
... previous studies with HIV-1 gp120 and SIV Env suggest that Env is nonglobular, precluding mass determina- tion by this method (5, ...mosaic virus were se- quentially absorbed onto ... See full document
5
A molecular determinant of human immunodeficiency virus particle assembly located in matrix antigen p17.
... in virus replication that recovered after a lag of about 1 ...here, p17 Cys-87 is unlikely to be involved directly in Gag-Gag interactions but may be involved in other aspects of infectious particle ... See full document
5
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein
... the type I -turn in the center of the MHR in the mature HIV-1 CA structure, and mutations at this po- sition do not reduce mature CA protein assembly in vitro ...make function- ally ... See full document
12
Rescue of human immunodeficiency virus type 1 matrix protein mutants by envelope glycoproteins with short cytoplasmic domains.
... Env protein spikes on the surface of the ...Env protein were infectious, at least a fraction of the Env protein must have been incorporated in a functional ...Some studies have suggested that ... See full document
7
Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism.
... calcium-binding protein which binds membranes in a myristate- and calcium- dependent manner (3, ...this protein, when free of calcium, demonstrates sequestration of the myristyl group within a deep ... See full document
11
Cellular and Viral Specificities of Human Immunodeficiency Virus Type 1 Vif Protein
... missive human cells (22, 32), the current data strongly indicate that this increases the infectivity of HIV-1 more than 100-fold but has no effect on the infectivity of amphotropic or xeno- tropic MLV that ... See full document
6
Analysis of the Assembly Function of the Human Immunodeficiency Virus Type 1 Gag Protein Nucleocapsid Domain
... The protein sequences used to replace NC were UPRT and HXGPRT enzymes from ...When protein samples from the transfected Cos7 cell lysates were assayed for UPRT and HXGPRT enzymatic activities (8, 9, 31), we ... See full document
8
Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging
... Several studies have reported that the affinity of NC for specific RNA sequences is poor and have suggested that additional portions of the Gag polyprotein may influence specificity (27, 32, ...chimeric ... See full document
11
The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity.
... of virus maturation (36a) that closely resembles the effect of the P31L ...several studies, differ- ent domains of Gag and Gag-Pol precursors must have tight contacts in order to mediate Gag and Gag-Pol ... See full document
7
Analysis of Human Immunodeficiency Virus Type 1 Matrix Binding to Membranes and Nucleic Acids
... The matrix (MA) domain of the human immunodeficiency virus type 1 (HIV-1) precursor Gag (PrGag) protein serves several functions in the viral replication ... See full document
8
Role of Invariant Thr80 in Human Immunodeficiency Virus Type 1 Protease Structure, Function, and Viral Infectivity
... simian immunodeficiency virus protease sequences found in the Los Alamos National Labo- ratory Database, residue 80 is 1 of only 10 residues invariant in ...Other studies have observed ... See full document
11
Structure-Function Analysis of the Epitope for 4E10, a Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody
... In summary, cyclic and acyclic analogs (native or Aib con- taining) were identified in which the tight binding to 4E10 (10 nM) was maintained (Table 2) and yet the possible backbone conformations adopted by the different ... See full document
8
Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vif Protein
... fractionation studies using cells transiently cotransfected with pIIIB/Dvif- and pgVif-derived vectors (data not ...high-titer virus stocks in 293T cells (a permissive cell line) and then to use them to ... See full document
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