[PDF] Top 20 Structure and function of the T cell antigen receptor
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Structure and function of the T cell antigen receptor
... This has been further supported by more recent experiments in which a heterologous receptor that activates the inositol phospholipid pathway, the human muscarinic receptor subtype 1, whe[r] ... See full document
9
The structure and function of vertebrate fibroblast growth factor receptor 1
... FGFR1 function during ...FGF receptor expressed at the MHB (Wilke et ...the receptor for FGF8-mediated signal transduction at the MHB in these ... See full document
8
Molecular characterisation of the T-cell receptors expressed in rheumatoid arthritis patients
... Structure of T cell antigen receptor fi chain in synovial fluid cells from patients with rheumatoid arthritis.. Elevation of a 10 T cell subset in peripheral blood and synovial fluid of [r] ... See full document
304
<p>Advances Of Chimeric Antigen Receptor T Cell Therapy In Ovarian Cancer</p>
... factor receptor 2 (HER2/neu), also known as HER2 or ERBB2, is a proto-oncogene and plays an important role in the pathogenesis and clinical process of various ...CAR-T cell therapy has shown good ... See full document
8
Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
... B cell aplasia, neurotoxicity, and infection are common adverse events of CAR-T cell therapy in CLL ...of T cell exhaustion ...IL-6 receptor antagonist tocilizumab and ... See full document
12
Critical factors in chimeric antigen receptor-modified T-cell (CAR-T) therapy for solid tumors
... in structure, which is the primary obstacle to the effectiveness of CAR-T ...of T-cell activation induced via abnormal expression of immunomodulatory factors as a complementary ...chemokine ... See full document
12
The Effect of T Cell Receptor Specificity on CD4+CD25+ Regulatory T Cell Function in an Autoimmune Setting
... suppressor function in response to stimulation by S1 peptide, we conducted in vitro suppression assays using S1 peptide to stimulate the ...+ T cells ...+ T cells at later cell divisions ... See full document
243
CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy
... B cell lymphoma and leukemia therapy [1, ...chimeric antigen receptor (CAR) – engineered T cells target- ing CD19 has opened a new era with “living drugs” for can- cer immunotherapy ... See full document
5
Chimeric antigen receptor costimulation domains modulate human regulatory T cell function
... the function of human T cells would no longer be ...cognate antigen of the CAR is expressed by the tissue requiring ...demonstrate antigen-spe- cific CAR-Treg functions, where ... See full document
20
<p>Case Report of Anti-CD123 Chimeric Antigen Receptor T-Cell Therapy Followed by Radiotherapy for a Recurrence of Blastic Plasmacytoid Dendritic Cell Neoplasm After Allogeneic Hematopoietic Stem Cell Transplantation</p>
... tumor cell apoptosis, 12 bortezomib, which downregu- lates NF-kB activity, 13 and 5 ʹ -azacytidine, which reduces tumor cell methylation ...gen receptor (CAR) T cells have been used in ... See full document
6
Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis
... of antigen receptor gene rearrangement including T cell receptor (TCR) and immunoglobulin heavy chain (IgH) by polymerase chain reaction followed by heteroduplex has currently become ... See full document
9
H-2 antigen expression and T cell function in murine radiation chimeras
... equivalent to that reported in standard (Px x P 2 )F i Pi chimeras (Blanden § Andrew 1979). Nevertheless, there was detectable Tc cell activity restricted to non-thymic parental H-2. Results in Tables 6.4 and 6.16 ... See full document
262
The Level of Viral Antigen Presented by Hepatocytes Influences CD8 T-Cell Function
... CD8 T cells varies in chronically infected patients due to inflammatory infiltrate, but the absolute number of intrahepatic HBcAg- specific CD8 T cells was found to be similar, irrespective of liver ... See full document
10
CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
... native T-cell in some tumors [10, 154], and side-effects of immune checkpoint blockade [155] pushed scientists to use novel gene-editing technologies to develop custom- ized T-cells for more ... See full document
17
From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
... in T cells or HCC cells ...+ T cell responses and poor IFN-γ production of CTLs [72, ...+ T cells, reducing ef- fector CD8 + T cells infiltration, and adhering to liver sinusoids to ... See full document
21
<p>Coexistence Of A Huge Venous Thromboembolism And Bleeding Tendency In Cytokine Release Syndrome During CAR-T Therapy</p>
... Abstract: Chimeric antigen receptor (CAR)-modi fi ed T cell therapy is increasingly adminis- tered for hematological malignancies. Cytokine release syndrome (CRS) is a common and severe ... See full document
6
Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming
... immune cell cytotoxicity and population change have been well studied in human and animal models, little is known about the functional alterations of the surviving immune cells after ionizing ...on T ... See full document
11
Progress and challenges in the vaccine-based treatment of head and neck cancers
... factor receptor-specific monoclonal anti- body, as well as has Panitumumab, a fully humanized IgG2 isotype monoclonal antibody, have been approved by the US Food and Drug Administration, and their clini- cal ... See full document
11
Chimeric antigen receptor T cell therapies for multiple myeloma
... B cell malignancies such as acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL) ...CAR-T cell therapy (CTL019) infusion led to a durable complete response in an advanced ... See full document
12
Characterization of the primary structure of T cell receptor beta chains in cells infiltrating the salivary gland in the sicca syndrome of HIV 1 infection Evidence of antigen driven clonal selection suggested by restricted combinations of V beta J beta gene segment usage and shared somatically encoded amino acid residues
... gland T cell receptor (TCR) repertoire, the primary structure of the TCR beta-chains was determined using in situ cDNA synthesis followed by the "anchored" polymerase chain ... See full document
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