[PDF] Top 20 Subcellular Localization of Simian Virus 40 Large Tumor Antigen
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Subcellular Localization of Simian Virus 40 Large Tumor Antigen
... The 96,000-molecular-weight anti-T-reactive surface protein was present in SV40-transforned mouse and hamster cells, as well as in productively infected monkey cells, but was not detecte[r] ... See full document
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Intestinal Hyperplasia Induced by Simian Virus 40 Large Tumor Antigen Requires E2F2
... the large T anti- gen contain little or no p130, consistent with cell culture experiments demonstrating that T antigen induces the pro- teasome-dependent degradation of p130 ...and subcellular ... See full document
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CD4+ T Lymphocytes Are Critical Mediators of Tumor Immunity to Simian Virus 40 Large Tumor Antigen Induced by Vaccination with Plasmid DNA
... Simian virus 40 (SV40) is a small, nonenveloped, DNA virus of the Polyomaviridae ...This virus was initially discovered as a contaminant of polio vaccines in the 1960s and has since ... See full document
9
The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.
... After incubation for 4 h, the cells were washed 5459 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The large tumor antigen T antigen of simian virus 40 is necessary a[r] ... See full document
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Antigenic structure of simian virus 40 large tumor antigen and association with cellular protein p53 on the surfaces of simian virus 40-infected and -transformed cells.
... The anti-T-ag monoclonal antibodies coprecipitated Several of the recognized biological activities of T-ag have the 53K cellular protein pS3 from the surface of SV40been assigned to rela[r] ... See full document
8
Dynamic nature of the association of large tumor antigen and p53 cellular protein with the surfaces of simian virus 40-transformed cells.
... mKSA-Asc cells were surface iodinated by the lactoperoxidase technique and subjected to external immunoprecipitation by normal mouse serum lanes 1 and 8 or MoaH-2.4 lanes 2 through 7 imm[r] ... See full document
7
The cellular secretory pathway is not utilized for biosynthesis, modification, or intracellular transport of the simian virus 40 large tumor antigen.
... This prediction presented an in vivo approach by which to assess the role of the secretory pathway in T-ag biosynthesis and transport, i.e., free and membrane-bound polyribosomes were pu[r] ... See full document
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Effects of in vitro dephosphorylation on DNA-binding and DNA helicase activities of simian virus 40 large tumor antigen.
... 22 showed that dephosphorylation by alkaline phosphatase increases the affinity of T antigen to the SV40 binding site II and, furthermore, that the activity of dephosphorylated T antigen[r] ... See full document
8
p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen.
... T antigen contains two independent regions (amino acids 1 to 147 and 251 to 708) with activities that cooperate with an activated ras oncogene in transformation assays (11), yet a T antigen lacking amino ... See full document
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Mutations near the carboxyl terminus of the simian virus 40 large tumor antigen alter viral host range.
... Nonviable mutants of simian virus 40 with deletions near the 3' end of gene A define a function for large T antigen required after onset of viral DNA replication.. Intracistronic complem[r] ... See full document
7
Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA
... small-DNA tumor viruses, for which the origins of replication are of well-defined nucleotide sequences (47, ...is large T antigen (T-ag), the initiator protein from simian virus ... See full document
13
Detection and characterization of multiple forms of simian virus 40 large T antigen.
... Simian virus 40 SV40 DNA codes for two early proteins, the large and small tumor T antigens 22, 30, 33, which can be immunoprecipitated from extracts of cells productively infected or tr[r] ... See full document
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An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53.
... Preliminary data suggest that PAb11O4 can bind to D2 protein, which lacks the N-terminal 82 amino acids of large T, whereas, in blocking studies with anti-T antibodies of the PAb200 seri[r] ... See full document
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Role of the Innate Immune Response and Tumor Immunity Associated with Simian Virus 40 Large Tumor Antigen
... the tumor-specific antigen simian virus 40 (SV40) large tumor antigen (Tag) following experimental pulmonary metastasis in naive ...mKSA tumor cell ... See full document
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Improved localization of phosphorylation sites in simian virus 40 large T antigen.
... Amino acid sequence analysis of fragments generated by partial proteolysis from large simian virus 40 tumor antigen.. Binding of dephosphorylated A protein to SV40 DNA.[r] ... See full document
17
Simian virus 40 large tumor antigen on replicating viral chromatin: tight binding and localization on the viral genome.
... 65-76 0022-538X/83/070065-12$02.00/0 Copyright C 1983, American Society for Microbiology Simian Virus 40 Large Tumor Antigen on Replicating Viral Chromatin: Tight Binding and Localizatio[r] ... See full document
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Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA.
... We can speculate that, although the newly synthesized 5 to 7S T antigen form is the active viral origin-binding form, the subsequently formed more rapidly sedimenting T antigen oligomers[r] ... See full document
11
Evidence for transmembrane orientation of acylated simian virus 40 large T antigen.
... 541 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest In mKSA cells a simian virus 40-transformed BALB/c mouse tumor cell line, plasma membrane-associated large T antigen[r] ... See full document
8
Association of simian virus 40 T antigen with replicating nucleoprotein complexes of simian virus 40.
... Recently, Mann and Hunter 30 detected SV40 large T antigen in the fraction of a sucrose gradient containing mature 70S NPCs by immunoprecipitation of T antigen labeled with [3S]methionin[r] ... See full document
11
Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells.
... 623 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Monkey and mouse cells producing simian virus 40 small t antigen in the absence of clearly detectable intact or trun[r] ... See full document
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