[PDF] Top 20 Suppression of cellular proliferation by the papillomavirus E2 protein.
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Suppression of cellular proliferation by the papillomavirus E2 protein.
... the E2 regulation of cellular proliferation, we examined whether BPV-1 E2-TR could suppress HeLa cell growth like the full- length BPV-1 ...BPV-1 E2-TA or BPV-1 ...growth ... See full document
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The Mitotic Chromosome Binding Activity of the Papillomavirus E2 Protein Correlates with Interaction with the Cellular Chromosomal Protein, Brd4
... BPV1 E2 protein mediates several key functions in the life cycle of the ...of E2 with mitotic chromosomes (5). In this study, a set of E2 pro- teins with mutations in the transactivation ... See full document
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Phosphorylation Regulates Binding of the Human Papillomavirus Type 8 E2 Protein to Host Chromosomes
... HPV8 E2 does not require either the N-ter- minal transactivation domain or the Brd4 interaction to bind to mitotic chromosomes ...HPV8 E2 protein has been shown to associate with the repetitive ... See full document
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Identification and Analysis of Papillomavirus E2 Protein Binding Sites in the Human Genome
... HPV E2 protein binding to cellular E2BSs determined by in silico analysis, ChIP analysis in transiently trans- fected human cell lines was ...HPV11 E2 was used for this analysis due to the ... See full document
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Tax1BP1 Interacts with Papillomavirus E2 and Regulates E2-Dependent Transcription and Stability
... The papillomavirus E2 proteins regulate viral replication, gene transcription, and genome maintenance by interacting with other viral and host ...the cellular protein Tax1BP1 as a novel ... See full document
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Human Papillomavirus E2 Protein: Linking Replication, Transcription, and RNA Processing
... a protein-coding ...final cellular protein ...specific cellular activators (serine-argin- ine-rich splicing factors [SRSFs]) and repressors (heterogeneous nuclear ribonucleoproteins [hnRNPs]) ... See full document
5
The Papillomavirus E2 Protein Binds to and Synergizes with C/EBP Factors Involved in Keratinocyte Differentiation
... HPV8 E2, C/EBP factors, and the C/EBP-specific DNA binding ...of E2 and C/EBP factors in vitro and in ...and cellular factors were formed also at the C/EBP binding ...whether E2 was recruited ... See full document
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Dimerization of the Papillomavirus E2 Protein Is Required for Efficient Mitotic Chromosome Association and Brd4 Binding
... The E2 proteins of several papillomaviruses link the viral genome to mitotic chromosomes to ensure retention and the efficient partitioning of genomes into daughter cells following cell ...1 E2 binds to ... See full document
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Human Papillomavirus Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein
... The papillomavirus (PV) E2 protein is a sequence-specific DNA binding protein that recruits cellular factors to its genome in infected epithelial ...cells. E2 also binds to and ... See full document
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Proteasomal Degradation of the Papillomavirus E2 Protein Is Inhibited by Overexpression of Bromodomain-Containing Protein 4
... many cellular genes, it is not surprising that it can also affect expression from the CMV ...of E2, independent of its effect on the CMV ...of E2 degradation not only because it is quantitative and ... See full document
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Both viral E2 protein and the cellular factor PEBP2 regulate transcription via E2 consensus sites within the bovine papillomavirus type 4 long control region.
... LCR E2 binding sites can mediate transactiva- tion or repression by full-length ...BPV1 E2 and BPV4 E2 upon transcription from the BPV4 LCR was assayed by cotransfecting the LCR luciferase constructs ... See full document
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Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions
... the E2 protein, which controls transcription, replication, and genome maintenance in in- fected ...affecting E2 function and stability have been demonstrated for multiple types of ...(BPV-1) ... See full document
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Interaction of Bovine Papillomavirus E2 Protein with Brd4 Stabilizes Its Association with Chromatin
... Brd4 protein was retained/stabilized in cells expressing E2, whereas about one-third of the E2 protein was associated with the chromatin/nuclear matrix frac- tion after taking into account the ... See full document
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A Novel Silencer Element in the Bovine Papillomavirus Type 4 Promoter Represses the Transcriptional Response to Papillomavirus E2 Protein
... mutant sequences, showing these mutated residues to be im- portant for sequence-specific binding in both PalK and PalF cells. In Fig. 7B, there is an apparent enhanced binding in PalK cells to PRE-2. However, this is due ... See full document
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HPV16 E2 could act as down regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation
... HPV E2 proteins have been shown to interact with TBP and a number of compo- nents of the basal transcription machinery [18,40-45], regulating the recruitment of the pre-initiation complex and affecting both viral ... See full document
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E2 represses the late gene promoter of human papillomavirus type 8 at high concentrations by interfering with cellular factors.
... 7.9)–135 mM KCl–4 mM spermidine–0.1 mM EDTA–1 mM DTT–0.05% (vol/ vol) NP-40–1 mg of bovine serum albumin per ml–12.5 m g of poly(dG-dC) per ml. Binding reactions with TBP alone were incubated in 60 mM KCl. For ... See full document
8
The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment
... HPV16 E2 important for association with ChlR1, we overlaid the crystal structures of the BPV1 and HPV16 E2 proteins (19, 20) and identified amino acids within HPV16 E2 that are in close physical ... See full document
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Bromodomain Protein 4 Mediates the Papillomavirus E2 Transcriptional Activation Function
... ing protein 4) mediates the association of BPV1 E2 to mitotic chromosomes and that the binding of E2 to Brd4 is conserved among the papillomaviruses ...of E2, this protein complex ... See full document
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Phosphorylation of a Conserved Tyrosine in the Papillomavirus E2 Protein Regulates Brd4 Binding and Viral Replication
... signal-induced proliferation-associated protein 1 (SPA1) ...HPV E2 proteins bind the BID domain of Brd4, while the PDID domain of Brd4 associates only with the DBD of high-risk E2 ...high-risk ... See full document
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Human Papillomavirus Type 16 E2 Protein Transcriptionally Activates the Promoter of a Key Cellular Splicing Factor, SF2/ASF
... Human papillomavirus type 16 (HPV16) infects cervical ep- ithelial cells, causing mainly benign lesions (cervical ...capsid protein expression is restricted to the granular layer cells ...capsid ... See full document
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