[PDF] Top 20 Suppression of PACT-Induced Type I Interferon Production by Herpes Simplex Virus 1 Us11 Protein

... The Us11-deficient HSV-1 was indistinguishable from the Us11-proficient virus in the suppression of interferon production when PACT was ...of interferon ... See full document

... wt PACT interaction with ...beta interferon by using PKR monoclonal antibody/protein ...then PACT were added to the immobilized PKR, followed by incubation for 15 min and then extensive ... See full document

... genes induced by virus infection and interferon, the eIF2 ␣ protein kinase PKR and the 2 ⴕ-5ⴕ oligoadenylate synthetase (OAS) are both activated by double-stranded RNA (dsRNA) produced in ... See full document

... to virus infection to get 90% confluence at the time of ...HSV-1 virus strains at a multiplicity of infection of 20 PFU per cell in cold phosphate-buffered saline (PBS) containing ...and 1% ... See full document

... a virus-host cell interaction, using wt HSV in culture, where a progressive repressive effect is estab- lished in a paracrine ...and protein targeting, HSV induced the ex- pression and secretion of ... See full document

... Denmark, 1 and Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 2 Received 11 December 2003/Accepted 3 February 2004 Viral immune evasion strategies are important for establishment ... See full document

... are induced rapidly upon viral ...be induced by IFNs during viral invasion and target different steps of the viral replication cycle ...tegument protein kinase Us3 and other HSV-1 proteins ... See full document

... ␣ 1 transgene into the vaginal lumen of C57BL/6 WT, RL ⫺/⫺ , PKR ⫺/⫺ , or PKR/RL ⫺/⫺ mice did not reduce the morbidity of infection as measured by the development of vaginal ...replicating virus in ... See full document

... The first model proposed above implies that the primary effect of ICP0 is to eliminate intrinsic cellular resistance to HSV-1 infection mediated through preexisting proteins that act to repress viral gene ... See full document

... the virus would target these structures is not. Since ectopically induced overexpression of PML had no effect on viral replication, the data suggested either that the destruction of ND10 was a consequence ... See full document

... rect protein conformation. The US11 protein is among the most-abundant viral proteins present in cells late in infection and is packaged in the tegument of the native virions ... See full document

... virus-specific protein kinase could be detected in cells infected with UV-inactivated HSV-1, demonstrating that a viable virus genome is required for its synthesis. Both results would al[r] ... See full document

... Herpes simplex virus type 1 (HSV-1) infection induces profound nucleolar modifications at the functional and organiza- tional levels, including nucleolar invasion by several ... See full document

... Homeodomain-interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase of the subfamily of dual-specificity Yak1-related kinase ...homeodomain-interacting protein kinase acting as a ... See full document

... of virus produced on U373 cells infected in parallel at low multiplicity was quantified by deter- mining titers of lysates on permissive Vero ...full-length Us11 protein ...full-length Us11 ... See full document

... Adult ICR/Sic or BALB/c mice developed hydrocephalus when attenuated herpes simplex virus type 1 (HSV-1) (strain Ska) was injected intracerebrally 2 to 4 weeks earlier and then after mic[r] ... See full document

... defense. Herpes simplex virus 1 (HSV-1) blocks autophagy in fibroblasts and in neurons, and the ...ICP34.5 protein is important for the resistance of HSV-1 to autophagy ... See full document

... Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells. Characterization of the early steps of herpes simplex replication in interfer[r] ... See full document

... To determine whether GKO and RGKO mice differ from 129/Sv//Ev controls in terms of infectious HSV-1 present in ganglia during latency, anesthetized 6- to 8-week-old male mice were inoculated with HSV-1 ... See full document

... fusion protein was eluted at 5 ml/min with 15 column volumes of a gradient from 0 to ...saline. Protein concentrations were determined using a Bio-Rad protein ...of protein was then used to ... See full document