[PDF] Top 20 Survivin Expression in Tuberous Sclerosis Complex Cells
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Survivin Expression in Tuberous Sclerosis Complex Cells
... Its expression profile is indicative of this role as it is detectable in embry- onic and fetal tissues, but poorly or not expressed in normal adult tissues ...cancer cells, and higher levels of ... See full document
12
Glucose deprivation in tuberous sclerosis complex-related tumors
... of cells with nuclear BrdU staining following in vivo labeling (Figure ...1,000 cells counted for each group, the proportion of BrdU(+) cells was signifi- cantly reduced with 2-DG treatment (Figure ... See full document
15
Exploiting Fission Yeast Genetic Interaction Data to Identify Disease-Specific Drug Targets for Tuberous Sclerosis Complex
... Third, a widespread phenomenon known as NGE can drastically affect large-scale genetic interaction data sets (Ben-Shitrit et al., 2012). NGEs can arise from the effects of gene deletions on the expression of ... See full document
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Everolimus improved renal function without reducing the size of a kidney angiomyolipoma in a patient with tuberous sclerosis complex: a case report
... disease expression, even among different patients and family members carrying the same mutations [6], several studies have demon- strated correlation between genotype and phenotype, in- cluding the nature and/or ... See full document
6
Tuberous sclerosis complex: everything old is new again
... that cells with second hits are either very difficult to detect in tubers and SEGAs or that distinctive mechanisms of tuberin or hamartin inactivation including phosphorylation are at work in the ... See full document
9
Genetics of tuberous sclerosis complex: implications for clinical practice
... normal intellectual function occurs commonly in TSC. Benign glial brain tumors known as subependymal giant cell astrocytomas (SEGAs) may grow within the lateral, third, or fourth ventricles in ~ 10%–20% of TSC patients, ... See full document
8
An unusual case of congenital melanocytic nevus presenting as neurocutaneous melanoma coexisting with Tuberous Sclerosis complex: A case report
... Microscopic examination of the patient’s scalp swel- ling revealed the presence of lining keratinized, stratified squamous epithelium and underlying dermis. The epi- dermis was thinned out with loss of rete pegs. Her ... See full document
5
Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase
... vided cells present at day 1 into 3 classes: cells that finally gave rise to one cell by Day 8 (in most cases neither di- vided nor died; class A), cells that gave rise to two or more cells ... See full document
13
mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disorders
... normal cells, the mTOR signaling cascade (also known as the phosphatidylinositol 3-kinase [PI3K]/pro- tein kinase B [Akt]/mTOR pathway) plays an important role in cell growth, proliferation, and survival ... See full document
9
Assessing the outcomes of everolimus on renal angiomyolipoma associated with tuberous sclerosis complex in China: a two years trial
... Adverse events were common, consistent with the known toxicities of everolimus and mostly of low grade. The most frequent adverse reactions we recorded were mucositis oral (100%), which was observed at the start of ... See full document
9
Clinical and Genotype Studies of Cardiac Tumors in 154 Patients With Tuberous Sclerosis Complex
... The natural history of CRs is intriguing and quite distinct from that of any other manifestation of TSC. However, another TSC lesion, pulmonary lymphangio- leiomyomatosis, is seen exclusively in females, implicat- ing ... See full document
8
Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2
... (ELT3) cells [49] were further studied by Astrinidis ...mammalian expression of TSC2) cell lines [24]. 621-101 human angiomyolipoma cells were derived and propagated by transformation of kidney ... See full document
14
Cerebral Diffusion Tensor MR Tractography in Tuberous Sclerosis Complex: Correlation with Neurologic Severity and Tract Based Spatial Statistical Analysis
... the tuberous sclerosis complex group were significantly smaller than those of the control sub- ...the tuberous sclerosis complex group (95% CI, ...the tuberous ... See full document
7
CD1a+ survivin+ dendritic cell infiltration in dermal lesions of systemic sclerosis
... the expression levels of survivin in PBMCs from SSc patients using RT-PCR (mRNA expression) and FACS (protein ...several survivin variants, as noted above [20], and three variants ... See full document
10
Towards personalised therapy for lymphangioleiomyomatosis: lessons from cancer
... ABSTRACT Lymphangioleiomyomatosis (LAM) is a rare cystic, destructive lung disease occurring almost exclusively in females. Bi-allelic inactivating tuberous sclerosis complex (TSC) gene mutations ... See full document
6
TOR gene, for example, mTOR (mammalian
... a complex net of signaling pathways that are involved both in normal physiological, as well as pathogenic ...and tuberous sclerosis complex (TSC) and several downstream ...the ... See full document
20
TAT-IL-24-KDEL-induced apoptosis is inhibited by survivin but restored by the small molecular survivin inhibitor, YM155, in cancer cells
... cancer cells and conferred protection against TAT- IL-24-KDEL-induced ...Furthermore, survivin overexpression inhibited the TAT-IL-24-KDEL-induced release of cytochrome c and Smac/DIABLO from the ... See full document
13
Incidence and Clinicopathological features of Neurocutaneous Disorders.
... Hypopigmentation is of 3 types – those resembling ash leaf macules, small punctate macules and local areas of hypoplasia that can appear blue red ( Pseudo atrophic macules ). Giant pigmented hairy naevi, cutis verticis ... See full document
75
Original Article Downregulation of survivin inhibits proliferation and migration of human gastric carcinoma cells
... with survivin in gastric ...that survivin play an important role in gastric cancer and the use of survivin siRNA might become effective approach to cancer ... See full document
6
Early manifestations of renal disease in patients with tuberous sclerosis complex
... We conducted a single-center, retrospective review of chil- dren and young adults (aged < 25 years of age) who were followed by the Tuberous Sclerosis Complex Center at NYU School of Medicine. ... See full document
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