[PDF] Top 20 SYK as a New Therapeutic Target in B Cell Precursor Acute Lymphoblastic Leukemia
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SYK as a New Therapeutic Target in B Cell Precursor Acute Lymphoblastic Leukemia
... the SYK kinase ...the SYK P-Site by C61 results in competitive inhibition of substrate binding and thereby blocks the SYK signaling ...of SYK, C61 does not inhibit other kinases ...a ... See full document
8
Recombinant human CD19L sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia
... of leukemia-associated morbidity, including reduced mobility, hunched posture, ruffled fur, or palpable splenomegaly at an ear- lier time point. All 11 untreated control mice developed fatal leu- kemia between 13 ... See full document
14
Molecular genetics of B precursor acute lymphoblastic leukemia
... murine leukemia cells leads to suppression of the MLL fusion protein– induced gene expression program (63), differentiation and/or apoptosis of leukemic cell lines, and suppression of leukemogen- esis ...a ... See full document
10
Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B cell precursor acute lymphoblastic leukemia
... resistance at the level of B-lineage LPC. The highest CD34 expression group (> or = 75% positivity) had 1.4-fold higher SF2 (P = 0.05) and twofold lower alpha values (P = 0.06) than the lowest group (< 30% ... See full document
9
Immunotargeting relapsed or refractory precursor B-cell acute lymphoblastic leukemia – role of blinatumomab
... a target cell is bound to the other scFv of the BiTE ...(physiological B-cells as well as precursor B-cell leukemic blasts) leads to a very close linkage with multiple ... See full document
12
B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3
... between B-cell precursor acute lymphoblastic leukemia (pre-B ALL) cells and stromal cells in the bone marrow that provide microenvironmentally-mediated protection against ... See full document
17
Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements
... during cell division, resulting in genome-wide demethylation ...of acute myeloid leukemia (AML) [12, ...refractory B-ALL patients [14, ...ALL cell lines ... See full document
13
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
... to be investigated in relation to CIMP status in ALL. Several mechanisms have been shown to influence the epigenetic landscape of ALL cells and recurrent mutations in genes involved in epigenetic regulation have been ... See full document
7
<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>
... these diseases in clinical outcomes. Hence, the fi rst step of this study was to determine the methodological criteria to improve the identi fi cation of each type. In our cohort, by revisiting the M-FCM, we identi fi ed ... See full document
11
MYC as therapeutic target in leukemia and lymphoma
... of leukemia and ...in acute lymphoblastic leukemia, acute myeloid leukemia, lymphoproliferative, and myeloproferative diseases, they are less ...in leukemia-derived cells ... See full document
17
Protein kinase inhibitors for acute leukemia
... many new mutation sites of protein kinase, the drug resistance to imatinib is more and more ...AML cell by blocking the activity of c-KIT pharmaco- logically [17, ...in acute leukemia (Table ... See full document
7
Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
... these cell types may not fully reflect ALL biology, the regions containing rs28665337 and rs17481869 show significant chromatin looping interactions with the promotor regions of MYC in ES cells and GTDC1 in GM12878, ... See full document
9
Acute B-Cell Lymphoblastic Leukemia/Acute B-Cell Lymphoblastic Lymphoma Presenting as Bilateral Breast Masses
... Metastases to the breast and axilla are rare and account for approximately 2% of all mammary malignancies [1,2]. The most common metastatic lesion to involve the breast is a metastasis from a contralateral mammary cancer ... See full document
5
Composite Multifocal Basal Cell carcinoma and Precursor B Acute Lymphoblastic Leukemia: Case report
... In conclusion we report an unusual case of composite multifocal precursor B-ALL and BCC. To the best of our knowledge this is the first case report in the English litera- ture of the synchronous multifocal ... See full document
7
Isotype-specific inhibition of the phosphatidylinositol-3-kinase pathway in hematologic malignancies
... The reasons for these advancements are several, but the main driver has been the increased and improved understanding of the multiplicity of intracellular pathways that could be affected during the oncogenic process, ... See full document
10
Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia
... Our work also underscores the importance of epi- genetic alterations in modulating lncRNA transcrip- tional activities. Although previous studies [60 – 62] have demonstrated cross-talk between DNA methyla- tion and ... See full document
16
PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia
... In B-cell precursor acute lymphoblastic leukemia (BCP-ALL) PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is frequently affected by ... See full document
6
Immunotherapy in hematologic malignancies: past, present, and future
... novel immunotherapies and establishing practice guide- lines, which will be essential with broadening use. More- over, it will be important to refine appropriate clinical endpoints and response assessments in studying ... See full document
10
Childhood pre B cell acute lymphoblastic leukemia with translocation t(1;19)(q21 1;p13 3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report
... different cell lineages and cell types: CD1a, CD2, CD3, CD4, CD5, CD8, CD10, CD11b, CD11c, CD13, CD14, CD15, CD16, CD19, CD20, CD22, CD23, CD32, CD33, CD34, CD38, CD41a, CD45, CD56, CD57, CD64, CD103, ... See full document
6
Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... 12). Leukemia-associated immunophe- notypes were determined by multivariable flow cytometry and multiple marker combinations (CD7/CD45/CD33/ CD34/CD117/CD10/CD2/cCD3/TDT and CD7/CD45/ ... See full document
11
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