[PDF] Top 20 Synthesis and evaluation of some pyrazoline derivatives as anticancer agents
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Synthesis and evaluation of some pyrazoline derivatives as anticancer agents
... Breast cancer is expected to account for 203 500 new cancer cases and 39 600 deaths in 2002. Although major advances have been made in early detection, prevention, and treatment, the need for more effective therapy in ... See full document
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SYNTHESIS AND BIOLOGICAL EVALUATION OF CHALCONE DERIVATIVES OF ACRIDINES AS ANTICANCER AGENTS
... The anticancer effect of ten synthetic chalcone fused acridine derivatives (10a-j) was evaluated on three human cancer cell lines such as MCF-7 (Beast), A549, MDA MB-231 (lung) by using the MTT assay and ... See full document
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SYNTHESIS AND BIOLOGICAL EVALUATION OF AMIDE DERIVATIVES OF THIAZOLES AS ANTICANCER AGENTS
... 0.12±0.027 µM, A549 = 0.11±0.027 µM and A375 = 1.89±0.35 µM) respectively. Instead of 4-chloro group with 4-bromo group having compound 11c have showed lower activity than 11b. Replacement of 4-bromo group with 4-nitro ... See full document
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Synthesis and Biological Evaluation of Amide derivatives of Benzophenone Derivatives as Anticancer Agents
... All these newly compounds (8a-j) were tested in vitro against three human cancer cell lines such as MCF-7, MDA MB-231(Breast cancer), A549 (Lung cancer) by MTT assay. All these derivatives exhibit potential ... See full document
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Synthesis, Characterization and Pharmacological Evaluation of Some New 1,4 Diazepine Derivatives as Anticancer agents
... 1,4-Diazepine derivatives are the seven membered, nitrogen containing heterocyclic ring systems possessing a wide range of therapeutic ...These derivatives are predominantly used in the inhibition of ... See full document
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Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents
... 2.2.3. Synthesis of 1-benzhydryl-1,4-diazepane (5) To a solution of homopiperazine 4 (5.0 g, 49.9 mmol) in dimethyl formamide, anhydrous potassium carbonate (20.7 g, 149.7 mmol) was added followed by the addition ... See full document
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Design, synthesis and biological evaluation of some novel Schiff base derivatives as potential anticancer agents
... Cytotoxicity of the novel pyrrolizines (18-20) was evaluated against HEPG2 and MCF7 cancer cell lines using Sulforhodamine-B (SRB) assay method as previously reported by Skehan et al.[29]. Antitumor activity ... See full document
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Synthesis and evaluation of L-glutamic acid analogs as potential anticancer agents
... General procedure used for the synthesis of N-substituted-5-oxopyrrolidine-2-carboxylic acid is as follows, in a 250 ml round bottom flask fitted with a CaCl 2 guard tube, 20 g (0.066 mol) of N-p- ... See full document
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Synthesis and Evaluation of New Substituted Pyrazoline Derivatives as Biological Agents
... Twelve new 3-(4-substituted benzyl)-5-(4-substituted phenyl)-1-phenyl-4, 5-dihydro-1H- pyrazole derivatives were synthesized by reacting 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one and phenyl ... See full document
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Synthesis and Biological Evaluation of Substituted Pyrazoline Derivatives Bearing 3,4,5 Trimethoxyphenyl Moiety as Anticancer, Anti inflammatory and Antioxidant Agents
... available anticancer agents manifested undesirable side effects such as low bioavailability, toxicity and drug-resistance ...procure anticancer agent with novel chemical entity and mode of ... See full document
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Synthesis and Antibacterial Evaluation of Some Novel Pyrazoline Derivatives
... antimicrobial agents to treat infectious diseases has been one of the most notable achievements of the past ...antimicrobial agents available in the market has resulted in the development of resistance to ... See full document
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Design, synthesis and biological evaluation of some novel pyrazoline derivatives
... different Pyrazoline derivatives were synthesized by cyclisation of substituted chalcone derivatives in the presence of 2, 4 dintro phenyl hydrazine ...their anticancer activities by MTT ... See full document
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SYNTHESIS AND EVALUATION OF NOVEL THIOSEMICARBAZONE DERIVATIVES AS ANTICANCER AGENTS
... INTRODUCTION: The cancer is one of the leading cause of deaths worldwide, in developing countries it is second leading cause of death while in developed countries it is leading cause of death. Till 2030 one among eight ... See full document
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Synthesis and evaluation of new pyrazoline and thiazolidinone derivatives as anticancer activity
... the synthesis of the target thiazolidone and pyrazoline ...the synthesis of the key intermediate and the final ...isothiocyanate derivatives with p-amino acetophenone in 1, 4-dioxan containing ... See full document
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CONVENTIONAL AND MICROWAVE ASSISTED SYNTHESIS OF SOME NEW DERIVATIVES OF COUMARIN CONTAINING PYRAZOLINE AND INVESTIGATION OF THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES
... Pyrazolines have played a crucial role in the development of theory in heterocyclic chemistry and also are extensively useful in organic chemistry . Due to interesting activity of various substituted pyrazolines as ... See full document
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Environmentally Benign Ultrasound Promoted Synthesis of Some Important Pyrazoline Derivatives as Antibacterial and Antifungal Agents
... of pyrazoline derivatives (4a-f) has been synthesized by ultrasonication methods and evaluated for its antibacterial and antifungal ...respective pyrazoline derivatives by using hydrazine ... See full document
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW CHALCONES AS POTENTIAL CYTOTOXIC AGENTS
... Chalcones with novel substituents were isolated earlier in our laboratories from different Tephrosia species possessing significant antimicrobial and anticancer activities. This has prompted us to synthesize a ... See full document
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Synthesis and in Vitro Cytotoxic Activity of Novel Pyrazole 3,4 dicarboxylates
... its derivatives, occupy an important posi- tion in medicinal chemistry with a wide range of bioac- ...imines. Evaluation of their cyto- toxic activity toward cell line P815 is ... See full document
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SYNTHESIS AND ANTICANCER EVALUATION OF SOME NOVEL FUSED PYRAZOLOPYRIMIDINE DERIVATIVES.
... Pyrazolo[1,5-a]pyrimidine derivatives are considered as significant class of heterocyclic compounds with pharmacological and biological activities, such as antidepressant[1], tuberculostatic[2] , antitumor, ... See full document
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NEWER BENZOFURAN DERIVATIVES AS POTENTIAL ANTICANCER AND ANTHELMINTIC AGENTS
... benzofurans are shown in Table 1. Presence of CONH group is essential for anticancer activity in benzofuran derivative. Presence of Phenolic and Chlorine group in compound 5c, 5d and 5i significantly affect ... See full document
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