[PDF] Top 20 T cells in the control of organ specific autoimmunity
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T cells in the control of organ specific autoimmunity
... stem cells, recently identified as a Sca1-expressing thymic epithelial cell population (31, ...of T cells is perturbed and autoreactive T cells now escape thymic ... See full document
12
Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia
... ⫹ T cells dramatically expand during acute HIV infection, tightly following the viral load ...⫹ T cells during acute ...⫹ T cells is inversely correlated with HIV progres- sion, ... See full document
12
CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation
... immunological control of mu- tant virus mCMV-IE1-L176A is precluded for two ...host cells infected with this virus fail to present the IE1 epitope, and second, this virus fails in priming an ... See full document
21
Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts
... regulatory T cell function, they share as a drawback the fact that such function occurs under lymphopenic conditions, where T cell homeostasis is dramatically changed by feedback mechanisms driving resi- ... See full document
7
Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes
... ⫹ T cell responses to overlapping HIV-1 peptides in order to clarify the correlation be- tween the T cell responses and clinical outcome (12, 28–32, 34– ...identify T cells effectively ... See full document
10
Critical role of EBNA1 specific CD4+ T cells in the control of mouse Burkitt lymphoma in vivo
... B6-BL cells by a retroviral vector encoding the EBNA1-GFP ...the control of viral long-terminal repeat ...a control, we generated a B6-BL/GFP cell ... See full document
10
Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity
... 293 cells when all CpG sites were ...+ T cells was also associated with increased apoptosis and was presumed to play a role in activation-induced cell death ...which T cell apopto- sis is an ... See full document
13
Myelin specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity
... healthy control mice that received no T ...and T cell recruitment exhibited a significant- ly greater fold induction in the brains of mice with CD4-initiated/ CD8 ... See full document
12
Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
... Regulatory T cells (Tregs) are a subset of CD4+ T cells with suppressive function and are critical in limiting ...the control of Treg ...of autoimmunity, non-obese diabetic (NOD) ... See full document
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CD28 costimulation independence of target organ versus circulating memory antigen specific CD4+ T cells
... (MBP-reactive) T cells in the blood were found to be less dependent on CD28 costimulation for T cell proliferation as compared with MBP-specific T cells from healthy ... See full document
10
γδ T cells and NK cells – Distinct Pathogenic Roles as Innate Like Immune Cells in CNS Autoimmunity
... γδ T cells, NKT, and innate lymphoid cells have been shown to be major sources of IL-17 in host control of a variety of bacterial, viral, and fungal ...Th17 cells, transfer of myelin ... See full document
6
Organ specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide
... spontaneous organ-spe- cific autoimmune diseases are provoked by systemic self- reactivity of T cells — reactivity that is generated through T cell repertoire selection that is directed by ... See full document
9
IL 2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ specific autoimmunity: implications in pathophysiology and translation to human disease
... Treg cells down-regulate Foxp3 expression, adopt an effector-like phenotype, and mice rapidly develop a fatal systemic autoimmune disease resembling the Scurfy syndrome ...+ cells, and a miR155 deficiency ... See full document
12
High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity
... of T-bet, GITR, CTLA-4, and ICOS, which imparted significant protection from autoimmune ...that T-bet expression in Tregs, necessary for control of Th1 autoimmunity, could be induced in an ... See full document
15
T cell homeostasis and systemic autoimmunity
... peripheral T cells is controlled are not yet well ...for T cell sur- vival in a resting state, may become overt under certain conditions associated with lymphopenia and lead to T cell ... See full document
7
Initiation and Regulation of CNS Autoimmunity: Balancing Immune Surveillance and Inflammation in the CNS
... to control chimeric mice ...These cells also expressed MHC class II and stained positive for myelin, indicating that they had the capacity to present myelin antigen to T cells and perhaps ... See full document
22
Marek’s disease in chickens: a review with focus on immunology
... dendritic cells and the type of maturation induced by different stimuli influences the immunological out- come, such as differentiation of Th1 ...T cells. There is very limited information on the ... See full document
19
Natural killer cells and autoimmunity
... NK cells before immunization resulted in significantly less severe EAU, demonstrating that NK cells participate in the development of EAU, either by directly mediating cellular damage or by supporting ... See full document
7
Reactive oxygen species in organ-specific autoimmunity
... been associated with the pathological damage typical of multiple sclerosis [62]. Indeed, several oxidized molecules can potentially be used as diagnostic biomarkers [63]. Increased levels of peroxynitrite are found in ... See full document
11
Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity.
... Treg cells have an antagonist ...pathogenic cells or their specific signaling ...to control the differentiation of Tregs and Th17 cells, ... See full document
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