[PDF] Top 20 Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
... without PI3K/PTEN mutations ...the PI3K pathway due to its influence on cellular metabolism and insulin/glucose regulation, NVP-BKM120 is the only inhibitor in clinical trials that has encountered ... See full document
14
Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels
... vertical targeting of the PI3K/Akt/ mTOR pathway in T-ALL cell ...the PI3K/Akt/mTOR network is characterized by multiple feed-back loops that finely act to regulate ... See full document
13
Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway
... that PI3K/AKT can regulate HIF-1α expression and is also involved in EMT [19, ...by targeting HIF-1α via modulating PI3K/AKT ... See full document
16
Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway
... included a 10-day treatment and 7-day rest. Tumor growth in treated groups was significantly inhibited (P,0.05) com- pared with controls (Figure 5A–C). No significant differences occurred in tumor volume between ... See full document
11
The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges
... the PI3K pathway such as AKT or PIK3CA translational studies will be required to determine whether these genomic alterations are associated with sensitivity to PI3K ...and PI3K pathways ... See full document
13
Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
... the PI3K/Akt/mTOR pathway was upregulated in DU145 docetaxel-resistant cells compared with the DU145-naïve ...Thus, targeting tau protein and PI3K/Akt/mTOR ... See full document
7
Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen
... to PI3K pathway inhibitors we screened compounds targeting PI3Kα/δ (AZD8835), PI3Kβ/δ (AZD8186), AKT (AZD5363) and mTORC1/2 (AZD2014) against a cancer cell line panel (971 cell ...to ... See full document
12
Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management.
... The PI3K-AKT-mTOR pathway is a well-established driver in human cancers and therefore blocking different nodes of this pathway is a relevant treatment ...with ... See full document
20
Pi3k Signaling Pathway and Pten in Triple Negative Breast Cancer
... (mTOR) pathway is a complicated intracellular pathway, which leads to cell growth and tumor proliferation and plays a significant role in endocrine resistance in breast ...compounds targeting ... See full document
29
Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
... (9). mTOR is involved in a pathway, known as PI3K/Akt/mTOR signaling pathway that regulates cellular growth behaviors which has the potential to lead to ...that mTOR does ... See full document
7
Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma
... the PI3K/AKT/ mTOR pathway and integrin β1 as downstream effectors of active BMP ...a PI3K/mTOR inhibitor (in vivo) revealed that targeting BMP7-mediated pathways could be ... See full document
16
The Effect of 12 Weeks Aerobic Training on Expression of AKT1 and mTORc1 genes in the Left Ventricle of Type 2 Diabetic Rats
... Characteristics of chronic heart failure has been shown to reduce left ventricular function and loss of cardio-myocytes through apoptosis or necrosis (22). It has been shown that a diabetic heart has a 85-fold increase ... See full document
7
Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress- mediated survival of melanoma cells
... Thus, targeting cancer cells with agents that increase ROS beyond this elevated threshold can lead to selective tumor cell death, with little effect on normal cells ... See full document
14
Original Article Prostaglandin transporter, SLCO2A1, mediates the invasion and apoptosis of lung cancer cells via PI3K/AKT/mTOR pathway
... In summary, SLCO2A1 exhibits the ability to mediate the invasion and apoptosis of lung cancer cells, possibly via regulating PI3K/AKT/ mTOR pathway. Knockdown of SLCO2A1 can inhibit lung ... See full document
7
Essig, Katharina (2019): A global definition of Roquin-mediated regulation of mRNA expression and translation uncovers its impact on PI3K-mTOR signaling and T cell differentiation. Dissertation, LMU München: Medizinische Fakultät
... cells, mTOR integrates a variety of environmental cues such as growth factors, nutrients, cytokines, co-stimulation, and TCR signals to translate them into distinct T cell fate decisions (Chapman and Chi, 2015; ... See full document
30
Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target
... Ly294002 targeting PI3K/AKT pathway, L-744832 targeting RAS, PD98059 targeting ERK/MAPK signaling and AG1296 targeting FLT3, the authors found that NF- κB DNA-binding ... See full document
11
Original Article MiR-29a is down-regulated and inhibits cell proliferation in osteosarcoma: a meta analysis
... Abstract: MiRNAs are a type of small noncoding RNA molecules with 18-25 nucleotides in length. Previous studies demonstrated miRNAs played as key regulators of gene expression and translation by binding to 3’UTR. MiRNA ... See full document
8
Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla
... signal pathway might accelerate the ability of osteo- genic/dentinogenic differentiation of ...Runx2- targeting molecules, including microRNA 338-3p, microtubule-associated protein tau, small heterodimer ... See full document
12
Recent advances on the progressive mechanism and therapy in castration-resistant prostate cancer
... drugs targeting the androgen axis pathway (androgen synthesis, androgen receptor splice variants, coactivators of AR and so on), PI3K-AKT pathway, WNT pathway, DNA repair, ... See full document
12
Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization
... SFV-induced PI3K-Akt-mTOR ...the PI3K-Akt-mTOR pathway is affected by infection of cells with SFV and to what extent this is influenced by nutrient availability, generally ... See full document
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