[PDF] Top 20 The C-Terminal Half of the Human Immunodeficiency Virus Type 1 Gag Precursor Is Sufficient for Efficient Particle Assembly
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The C-Terminal Half of the Human Immunodeficiency Virus Type 1 Gag Precursor Is Sufficient for Efficient Particle Assembly
... the assembly of Gag precursor molecules into spherical protein ...sarcoma virus (RSV), three distinct assembly domains have been defined which together comprise no more than 25% of the ... See full document
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Analysis of Minimal Human Immunodeficiency Virus Type 1 gag Coding Sequences Capable of Virus-Like Particle Assembly and Release
... progressive C-terminal truncations ...the C-terminal truncation mutations (Fig. 1B). To construct the p6 Gag deletion mutation, two consecutive stop codons were introduced into the ... See full document
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Myristoylation Is Required for Human Immunodeficiency Virus Type 1 Gag-Gag Multimerization in Mammalian Cells
... of Gag is essential for Gag-Gag multimerization in ...of particle assembly do not require myristoylated Gag ...retroviral Gag proteins are stimulated to multimerize ... See full document
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Particle Size Determinants in the Human Immunodeficiency Virus Type 1 Gag Protein
... the assembly domains abolish or severely impair particle production, regions that lie outside these domains can be deleted without any effect on particle release or ...for assembly process ... See full document
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A Putative α-Helical Structure Which Overlaps the Capsid-p2 Boundary in the Human Immunodeficiency Virus Type 1 Gag Precursor Is Crucial for Viral Particle Assembly
... and virus replication was monitored by measuring RT activity in the culture superna- ...for virus replication was detected for up to 30 days in cultures transfected with the E2G and E2P mutants ... See full document
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Characterization of deletion mutations in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation.
... were efficient particle producers suggested two regions that could be important for assembly: one across the p17-p24 cleavage site and the other near the p24-p2 cleavage ...in assembly (7, 27, ... See full document
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Mutation of Dileucine-Like Motifs in the Human Immunodeficiency Virus Type 1 Capsid Disrupts Virus Assembly, Gag-Gag Interactions, Gag-Membrane Binding, and Virion Maturation
... located C terminal to CA and NC, ...in Gag that interact directly with the lipid bilayer and thus regulate the binding of Gag to mem- ...the C-terminal domain (CTD), which bears ... See full document
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Human immunodeficiency virus type 1 MA deletion mutants expressed in baculovirus-infected cells: cis and trans effects on the Gag precursor assembly pathway.
... of human immunodeficiency virus type 1 in intracellular transport, assembly, and extracellular release of Gag polyprotein precursor (Pr55 gag ) was ... See full document
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Analysis of Human Immunodeficiency Virus Type 1 Gag Dimerization-Induced Assembly
... the precursor Gag (PrGag) pro- teins of retroviruses such as human immunodeficiency virus (HIV), Rous sarcoma virus (RSV), and murine leukemia vi- ruses are sufficient for ... See full document
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Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.
... long terminal repeat of the HIV-1 ...in particle assembly and release; hatched triangles indicate mutants which release particles with an altered p24/p25 ... See full document
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Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.
... morphogenesis. Gag-Pol mediates incorporation of the viral enzymes, and it is part of the assembling capsid structure and, therefore, is directly in- volved in the formation of infectious ...the ... See full document
7
Analysis of the Assembly Function of the Human Immunodeficiency Virus Type 1 Gag Protein Nucleocapsid Domain
... the gag gene, causing the gag ORF to terminate 11 residues after (TARK), precisely at (TAM), or 5 residues before (ApoTE) the junction of p2 and ...the gag coding sequences of these constructs, were ... See full document
8
Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal.
... The results show that while matrix is not required for HIV-1 viral assembly and release, myristylation of the Gag polyprotein precursor serves to facilitate efficient particle release.. [r] ... See full document
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The Nucleocapsid Region of Human Immunodeficiency Virus Type 1 Gag Assists in the Coordination of Assembly and Gag Processing: Role for RNA-Gag Binding in the Early Stages of Assembly
... three C-terminal NC residues remain) fails to efficiently form particles (43), a result previously observed by others (12, 15, ...NX Gag expression or its overt stability in the cell, consistent with ... See full document
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Efficient Particle Production by Minimal Gag Constructs Which Retain the Carboxy-Terminal Domain of Human Immunodeficiency Virus Type 1 Capsid-p2 and a Late Assembly Domain
... retroviruses, efficient virus release can evidently be achieved in other ways, as exemplified by the ability of leucine zipper domains to replace ...allow Gag-Gag interactions to remain ... See full document
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Roles of Matrix, p2, and N-Terminal Myristoylation in Human Immunodeficiency Virus Type 1 Gag Assembly
... Human immunodeficiency virus type 1 Gag protein is cotranslationally myristoylated at the N terminus and targeted to the plasma membrane, where virus particle ... See full document
8
The Mason-Pfizer Monkey Virus Internal Scaffold Domain Enables In Vitro Assembly of Human Immunodeficiency Virus Type 1 Gag
... analyzed Gag domain func- tion in assembly by the creation of chimeric Gag proteins, and they have shown that several domains of Gag can be substi- tuted by the equivalent domains from another ... See full document
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The C-Terminal Portion of the Hrs Protein Interacts with Tsg101 and Interferes with Human Immunodeficiency Virus Type 1 Gag Particle Production
... the C-terminal fragment was expressed at lower levels, it showed a strong inhibitory effect on HIV-1 Gag-Pol particle ...production. Gag precursor protein expression and ... See full document
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Ubiquitination of Human Immunodeficiency Virus Type 1 Gag Is Highly Dependent on Gag Membrane Association
... Unprocessed Gag polyproteins were initially soluble in RIPA buffer but became rapidly insoluble due to multimerization and were then inac- cessible to antiserum against CA under native ...detergent-resistant ... See full document
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In Vitro Assembly Properties of Human Immunodeficiency Virus Type 1 Gag Protein Lacking the p6 Domain
... HIV-1 Gag and have been described elsewhere (8). For expression of HIV Gag, the MA and CA segments of the gag gene of HIV-1 strain BH10 (plasmid BH10 gp II [GenBank; NIDg 326383], a ... See full document
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