[PDF] Top 20 Tissue-specific variation in DNA methylation levels along human chromosome 1
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Tissue-specific variation in DNA methylation levels along human chromosome 1
... simulated methylation levels were uniform (Figure ...overall methylation levels simulated for the two samples, relative simulated levels of back- ground signals on the array spots (for ... See full document
21
Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue
... Differential DNA methylation has a particular impor- tance in establishing and maintaining mono-allelic imprinted gene ...parent-of-origin specific methylation regulates the bind- ing of ... See full document
13
DNA methylome profiling of human tissues identifies global and tissue specific methylation patterns
... sequence-specific DNA methylation as a regulatory mechanism works on regions larger than 1,000 base pairs ...and tissue-specific gene expression ...between methylation beta ... See full document
14
Original Article Decreased LINE-1 methylation levels in aldosterone-producing adenoma
... LINE-1 methylation and APA appears to be indepen- dent of gender, age, tumor diameter, maximum mean arterial pressure, basic plasma aldoste- rone concentration and aldosterone-renin ...LINE-1 ... See full document
8
Variation of global DNA methylation levels with age and in autistic children
... between DNA methylation and age-related dis- eases [9, 20, ...global DNA methylation is one of the first epigenetic abnormalities in cancers [6], and advanced age represents a potent risk fac- ... See full document
6
X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells
... region 1 harbored the X- linked modifier of methylation, female carriers of chromosomal duplications of this region would have higher methylation levels than females without duplica- ...ZPBP2 ... See full document
10
Sex differences in the genome wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
... Genomic DNA (500 ng) was bisulfite converted using an EZ DNA methyla- tion kit (Zymo Research, Orange, CA, ...converted DNA was used to analyze DNA methylation with Infinium®assay using ... See full document
22
Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer
... each tissue type, which was then finally evaluated in the blind test set (“Methods” ...six tissue types, both model selection procedures (forward selection and AIC) revealed that a three-predictor (histone) ... See full document
11
An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs
... similar levels of non-variable CpGs DNAm data from publicly available studies was collected for blood, buccal epithelial cells and placenta (21, 3 and 4 studies, ...file 1: Table ...same tissue but ... See full document
8
Identification of specific DNA methylation sites on the Y-chromosome as biomarker in prostate cancer
... the DNA methylation levels of the 6 sites were caused by base pair mutations, we performed whole-genome sequencing of all 66 pairs of PCa tissues and adjacent normal ...aberrant methylation of ... See full document
11
Tissue specific patterns of allelically skewed DNA methylation
... intermediate DNA methylation. Flanking regions (1 kb) of variable ASM sites show a signi fi cant enrichment in intermediately methylated probes on the Illumina 450K Human Methylation ... See full document
14
Extensive epigenetic reprogramming during the life cycle of Marchantia polymorpha
... cytosine methylation between the autosomal scaffolds, the two scaffolds making up the Y chromosome, and the nine scaffolds constituting the X chromosome ...Overall DNA methylation ... See full document
17
Tissue-specific DNA methylation profiles in newborns
... population. DNA methylation studies often select imprinted loci as candidate genes, because DNA methylation levels at these loci were assumed to be comparable in different ...In ... See full document
5
Reduced intrinsic DNA curvature leads to increased mutation rate
... Characterization of the mutational landscape of URA3 To quantitatively determine how cis elements affect the local mutation rate, we first characterized the mutational landscape of an endogenous gene, URA3 , in Saccharo- ... See full document
12
DNA methylation study of fetus genome through a genome-wide analysis
... of DNA interaction in chromatin immunoprecipitation (ChIP) experiments, understanding global epigenomic changes like ...the methylation status during embryonic ...hyper- methylation and ... See full document
8
X-chromosome inactivation, DNA methylation and imprinting
... a specific site will be methylated by MTase in ...stranded DNA and S-adenosyl-L-homocysteine (SAH) (Sano & Sager, ...in DNA or RNA complexes and they may compete away or trap the MTase from ... See full document
434
6252.pdf
... Didion, Dr. Jeremy R. Wang, Dr. Jeremy B. Searle, Dr. Leonard McMillan, Dr. William Valdar and Dr. Fernando Pardo-Manuel de Villena. The aim of these experiments was to fine map Xce, investigate the haplotype diversity ... See full document
149
Phenotypic alteration of CD8 T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming
... genomic DNA was carried out using EZ DNA Methylation Gold kit (Zymo ...converted DNA was analyzed using Illumina Infinium 450K Methylation array according to manufacturer’s suggested ... See full document
13
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... template DNA also becomes critical when a limited amount of tissue material is available from archived human ...genomic DNA before extraction, thereby reducing the significant loss of template ... See full document
8
Novel prodrugs of decitabine with greater metabolic stability and less toxicity
... NaCl; 1 mM EDTA; 0.1% SDS; and 1% NP-40) containing 3 mM di- thiothreitol, proteinase inhibitor cocktail (Nacalai Tes- que; Kyoto, ...(Abcam, 1:1000) or mouse anti-PARP antibody (BD, ...IgG, ... See full document
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