[PDF] Top 20 Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes
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Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes
... SNPs for evidence of expression influencing risk, constrains study power. The TWAS approach is essentially agnostic as it jointly considers all SNPs in the region, regardless of re- ported GWAS association ... See full document
8
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
... near genes which have either been previously implicated in the development of cHL or have established roles in B-cell develop- ment and are therefore strong candidates for cHL ...6q22.33 association marked ... See full document
11
A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.
... Cancer Study Group was supported by the ...Cancer Study gratefully acknowledges additional support from Ovarian Cancer Australia and the Peter MacCallum Foundation; BAV: ELAN Funds of the University of ... See full document
37
Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population
... Results: The data revealed that 2 SNPs were associated with PH overall susceptibility at p < 3×10 − 4 after Bonferroni correction. The top hit was rs6557421 (p = 4.5×10 − 9 ), located within Nox3 gene on ... See full document
8
Genome-wide association study identifies multiple susceptibility loci for glioma
... an association between SNP genotype and expression of genes mapping within 1 Mb of the sentinel SNP (Supplementary Data ...for multiple testing within each region no statistically significant eQTL was ... See full document
9
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.
... rank genes for functional validation at known risk regions 24 – 28 ...multi-tissue transcriptome-wide association study 24–26 to identify new risk regions and to prioritize genes ... See full document
11
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
... genome-wide association studies (GWAS) have successfully identified 13 loci associated with risk of chronic lymphocytic leukemia/ small lymphocytic lymphoma ...CLL susceptibility loci, we conducted ... See full document
26
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
... associations are mediated through these genes. ELK3, an ETS- domain transcription factor is an attractive candidate for de fi ning ALL susceptibility a priori as it has a role in both B-cell ... See full document
7
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.
... MM susceptibility loci, we analysed genome-wide association data from six populations of European ancestry (Supplementary Tables 1 and 2): a new sample set from the Netherlands, two previously ... See full document
9
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
... The authors thank Jing He, Wanqing Wen, Ayush Giri, and Todd Edwards of Vanderbilt Epidemiology Center and Rao Tao of Department of Biostatistics, Vanderbilt University Medical Center for their help with the data ... See full document
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Genome-Wide Association Study Identifies QTL and Candidate Genes Governing Seed Mucilage Content and Hull Content in Flax (Linum usitatissimum L.)
... GWAS was performed in TASSEL v.5.2.31 [70] using the 771,914 filtered SNPs. Three models were performed including GLM-Q, GLM-PCA and MLM-K. The Q matrix generated from STRUCTURE was used as cofactor to adjust for ... See full document
19
Genome wide association study identifies a susceptibility locus for comitant esotropia and suggests a parent of origin effect
... of multiple 5 m CpG islands within WRB (CGI-2; Chr21: 40757603- ...a candidate maternally imprinted ...neighboring genes, suggesting that the maternal imprinting of WRB is isoform- and/or ...target ... See full document
11
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
... removed. Association analysis between imputed SNPs and disease status was performed using the same regression model as for genotyped SNPs, but with dosage probabilities as predictors, rather than the actual ... See full document
25
Integrating transcriptome wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies
... novel susceptibility genes contributing to the overlapped genetic mechanism of various chondro- ...common genes. The results of these common genes could be more reli- able because they are not ... See full document
9
Association of UBE2E2 and KLF14 gene polymorphisms and risk of type 2 diabetes mellitus: Asian meta-analysis
... Diabetes is one of the largest global health emergencies in the twenty-first century *1+. Type 2 diabetes (T2D) is the most prevalent form of diabetes, it is accounts for more than 90% of all diabetes types worldwide, ... See full document
11
Updating Genetics Polymorphisms of Non Syndromic Clefts Lip Palates
... including wide linking genome mapping association and candidate gene ...key genes in the genesis of NSCLP/CP represents a major ...(genome wide association study) studies ... See full document
8
The molecular genetic basis of natural variation in trichome density in Arabidopsis thaliana : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Plant Biology, Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand
... 61 Trichomes are single- or multi-cellular projections from the plant aerial epidermis, found in most land plant lineages, although not all trichomes are homologous (Werker, 2000). Trichomes have a diverse range of ... See full document
179
Large scale genotyping study for asthma in the Japanese population
... 14. Yamaguchi-Kabata Y, Nakazono K, Takahashi A, Saito S, Hosono N, Kubo M, Nakamura Y, Kamatani N: Japanese population struc- ture, based on SNP genotypes from 7003 individuals com- pared to other ethnic groups: effects ... See full document
5
Original Article Genetic association of VDR polymorphisms and multiple myeloma susceptibility: a case control study
... A cohort of 230 individuals were enrolled in this case control study, including 113 patients with MM and 117 healthy controls. The 113 patients were histologically conformed MM who were admitted to the Affiliated ... See full document
5
Identification of candidate genes controlling oil content by combination of genome-wide association and transcriptome analysis in the oilseed crop Brassica napus
... The candidate gene regions with SOC as determined by GWAS analysis were the 300-kb flanking regions on either side of the markers significantly associated with SOC, as described previously ...All genes ... See full document
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