[PDF] Top 20 Understanding brain dysfunction in sepsis
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Understanding brain dysfunction in sepsis
... BBB dysfunction and release of various mediators into the ...of sepsis, endothelial nitric oxide synthase-derived nitric oxide exhibits proinflammatory characteristics and contributes to the activation and ... See full document
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Bench to bedside review: β Adrenergic modulation in sepsis
... Sepsis still places a burden on the healthcare system, with an annual increase in incidence of about 9% and a mortality of about 25% and up to 60% when shock is present [1,2]. Uncontrolled systemic inflammatory ... See full document
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Clinical neurophysiological assessment of sepsis associated brain dysfunction: a systematic review
... with sepsis [18,20,21] and from 4% to 22% in the mixed population ...cerebral dysfunction and greater mortality ...studies, sepsis was a significant risk factor for periodic discharges whereas ... See full document
12
A clinical perspective of sepsis-associated delirium
... term sepsis-associated encephalopathy (SAE) has been applied to animal models, postmortem studies in patients, and severe cases of ...of brain dysfunction, including delirium, coma, seizure, and ... See full document
7
Inhibition of complement C5a prevents breakdown of the blood brain barrier and pituitary dysfunction in experimental sepsis
... of sepsis in the ...inflammation-mediated dysfunction of the blood-brain barrier (BBB), thus allowing neurotoxic mediators to extravasate from the peripheral circulation into the sub- arachnoid space ... See full document
9
Advances in sepsis-associated liver dysfunction
... liver dysfunction as an early event in sepsis. Sepsis-associated liver dysfunction is mainly resulted from systemic or microcirculatory disturbances, spillovers of bacteria and endotoxin ... See full document
9
Histopathological changes of organ dysfunction in sepsis
... [53] and by Pseudomonas pyocyanea and S. aureus (plus 4 cases with negative cultures) in the other report [54]. They attributed their findings to a generalized Schwartzmann phenomenon (endotoxin-induced vascular ... See full document
15
Mitochondrial dysfunction during different sepsis forms
... in sepsis development. We presume that the lengthy course of sepsis and extended exposure to reactive nitrogen species results in irreversible inhibition or permanent damage to the enzyme ...mitochondrial ... See full document
7
CD40-CD40 Ligand Pathway Is a Major Component of Acute Neuroinflammation and Contributes to Long-term Cognitive Dysfunction after Sepsis
... to brain dysfunction ...the dysfunction of the BBB that is implicated in the pathogenesis of SAE ...after sepsis induction ...decrease brain inflamma- tion and improve long-term ... See full document
8
Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis
... endothelial dysfunction, chronic in- flammation, accumulation of urea or of vasoactive spe- cies, and alterations in sympathetic nervous system- driven vascular resistance ...renal dysfunction on cerebral ... See full document
9
Neurocritical care update
... arrest brain injury, the evaluation of the injury and its corresponding therapy, including temperature modulation, is ...traumatic brain injury, the diverse effects of therapeutic hypothermia depend on the ... See full document
10
Potential therapy strategy: targeting mitochondrial dysfunction in sepsis
... for sepsis recovery ...after sepsis in young but not aged mice with significant defect in mitochondrial ...of sepsis, mitochon- drial biogenesis is activated in mouse kidneys accompan- ied by active ... See full document
11
Sepsis-induced myocardial dysfunction: pathophysiology and management
... LV dysfunction and a further 44 % had echocardiographic features of diastolic dysfunction ...myocardial dysfunction [21]. Importantly, cardiovascular dysfunction in sepsis is associated ... See full document
10
Levosimendan for the prevention of acute organ dysfunction in sepsis
... We conducted a double-blind, randomized clinical trial to investigate whether levosimendan reduces the severity of organ dysfunction in adults with sepsis. Patients were randomly assigned to receive a ... See full document
12
Brain microabscesses in a porcine model of Staphylococcus aureus sepsis
... of brain abscesses in ...porcine sepsis with one exception: different from humans pigs have a microarteriolar meshwork, the rete mirabile, interposed between the internal carotid artery and the Circle of ... See full document
5
Organ dysfunction as a new standard for defining sepsis
... of sepsis, these systems tend to dysfunction, a condition referred to as disseminated intravascular coagulation (DIC), which induces organ dysfunction and is closely associated with higher ...new ... See full document
6
Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis
... In sepsis, it has been shown that lymphocyte apop- tosis may be induced by a high inflammatory status, contributing to a worse prognosis ...of sepsis. One of the key pro-inflammatory cytokines in ... See full document
10
Evaluation of sepsis induced cardiac dysfunction as a predictor of mortality
... This small study has shown that MAPSE when com- bined with APACHE II score is a good predictor of mortality. Among the echocardiographic parameters MAPSE alone was a good predictor of mortality. Cardiac biomarker ... See full document
7
Bench to bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
... During sepsis the proco- agulant activity of TF increases, with transcriptional upregula- tion of its expression on monocytes and ECs among other cell types, whereas levels of endothelium anticoagulant mem- brane ... See full document
9
Microvascular endothelial dysfunction: a renewed appreciation of sepsis pathophysiology
... acute sepsis, with the balance tipped in favour of procoagulation (through increased TF and thrombin expression, with decreased activation of thrombomodulin and Protein C) and antifibrinolysis (through plasminogen ... See full document
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