[PDF] Top 20 The utilization of humanized mouse models for the study of human retroviral infections
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The utilization of humanized mouse models for the study of human retroviral infections
... The humanized NOD-SCID models are based on the SCID mutation which can result in a leakiness marked by low level production of mouse immunoglobulins and T- cell receptors over ...the study of ... See full document
18
Humanized mouse models for Epstein Barr virus infection
... immortalizing human B cells into persistently growing lymphoma cell ...reconstituted human immune system components provide an informative in vivo model to study EBV infection, the associated tumor ... See full document
18
HLA transgenic mice as humanized mouse models of disease and immunity
... a human MHC class II molecule was shown ...to mouse CII which could have been crucial in the disease ...novel humanized animal model to study autoim- mune arthritis and suggested that HLA-DQ ... See full document
7
Humanized mouse models reveal an immunologic classification of idiopathic CD4 lymphocytopenia subtypes
... 2 humanized mouse models in which either HSCs or mature T cells from patients with ICL were removed from their human environment and placed in an in vivo system that allowed the study ... See full document
14
HIV Latency in the Humanized BLT Mouse
... vivo models that can be used to test purging ...marrow-liver-thymus) mouse can be used as both an abundant source of primary latently infected cells for ex vivo latency analysis and also as an in vivo ... See full document
9
Development of a new humanized mouse model to study acute inflammatory arthritis
... this mouse and is suppressed by a TNF-α inhibitor and is associated with reduction of human but not mouse leu- kocytes in the joint (Figure ...the human macrophages play in this ...that ... See full document
9
A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis
... are human, human IL-5 is neces- sary for the expansion of human eosinophils in blood and the induction of eosinophilic inflammation in our humanized mouse ...as human eosinophils ... See full document
16
Multiple genetically engineered humanized microenvironments in a single mouse
... and human HSPC ...host mouse. Finally, implanted microenvironments can ac- commodate human HSPCs and be directly accessed for various imaging and analytical tools [20, ...the study of ... See full document
13
Versatile humanized niche model enables study of normal and malignant human hematopoiesis
... nodeficient mouse models, followed by cellular studies of murine BM tissue, is the most common assay for studying normal and malignant human ...new mouse strains encoding human ... See full document
6
Hemopexin in severe inflammation and infection: mouse models and human diseases
... the human Hx dynamics in mouse inflammatory models and therefore it may be necessary to search for a different species to model the heme axis in human ...treatment study using patients ... See full document
8
Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection
... dengue infections worldwide every ...the study of dengue pathogen- esis and the development of ...metabolomics study on a model using humanized mice with dengue infection that had significant ... See full document
10
Evolution of the HIV-1 env Gene in the Rag2−/− γC−/− Humanized Mouse Model
... Current models being used to study various aspects of HIV-1 infection include the genetically immunodeficient Rag2 ⫺/⫺ ␥ C ⫺/⫺ mouse reconstituted with a human immune system by transplantation ... See full document
13
Mouse models of human phenylketonuria.
... The major result that we report is the establishment of two mutant mouse strains that each closely simulate human PKU. PAH enzyme is much reduced, and blood PHE and urinary [r] ... See full document
6
Structure of a human retroviral sequence related to mouse mammary tumor virus.
... Hybridization to digests of normal and tumor cell DNA indicated that NMWV 4 and a few closely related sequences are endogenous to the human genome.. The regions that contain homology to [r] ... See full document
7
Retroviral-mediated transmission of a mouse VL30 RNA to human melanoma cells promotes metastasis in an immunodeficient mouse model
... a human melanoma cell line by a retroviral vector resulted in transmission of a mouse VL30 (mVL30-1) retroelement RNA to some of the cells infected by the retrovirus, followed by synthesis, ... See full document
5
Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model
... of human serum, the hu- man proteins present in the serum of huPBL-NSG ani- mals can only originate from the cells that have been implanted and those expanded during the period of en- ...with human PBL ... See full document
11
Development and characterization of mouse models of human glioblastoma
... astrocytoma models, the GFAP promoter is largely used to direct gene mutations in astrocytes either by straight transgenic technique or conditional induction mediated by ...some models (Zhu et al 2005; ... See full document
159
Insights from mouse models into human retinoblastoma
... replication-deficient retroviral vectors ...same study, while 12 of 115 control clones in Rb lox/+ ani- mals contained bipolar cells following Cre expression, 0 of 82 clones in Rb lox/- animals contained ... See full document
16
Genetically engineered mouse models and human osteosarcoma
... Rodent models of OS have been established for many decades and were originally generated through the ex- posure to chemical and radioactive ...These models demonstrated the principle of high- penetrance OS ... See full document
14
Effect of Glycyrrhizin on Pseudomonal Skin Infections in Human-Mouse Chimeras
... Figure 3. Effect of glycyrrhizin on the resistance of chimeras against sepsis stemming from P. aeruginosa i.d. infections. A. Survival of patient chimera substitutes i.d. infected with 20 LD 50 of P. aeruginosa. ... See full document
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